exo-N-isopropylbicyclo[2.2.1]hept-2-ene-2,3-dicarboximide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: exo-N-isopropylbicyclo[2.2.1]hept-2-ene-2,3-dicarboximide
• 英文别名: (1S,2S,6R,7R)-4-propan-2-yl-4-azatricyclo[5.2.1.02,6]dec-8-ene-3,5-dione
• 化学式: C₁₂H₁₅NO₂
• 分子量: 205.257
• InChiKey: CCGKCUKWRHWJSR-FIRGSJFUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  exo-N-isopropylbicyclo[2.2.1]hept-2-ene-2,3-dicarboximide 在 palladium on activated charcoal 氢气 作用下， 生成 N-(isopropyl)norbornane-endo-2,3-dicarboximide
  参考文献：
  名称：

  N-(Isopropyl)norbornane-endo-2,3-dicarboximide

  摘要：

  The geometry of the title molecule, N-isopropylbicyclo-[2.2.1]heptane-endo-2,3-dicarboximide, C12H17NO2, has been confirmed as the endo conformation. The orientation of the isopropyl (Pr-i) group relative to the succinimide moiety is a little unsymmetric and the Pr-i group rotates ca 6 degrees around the N-C bond from the perpendicular configuration. This causes the stereoselectivity of the photoreaction in the solid state. The diastereo-excess of the ring expansion products indicates that the carbonyl-O atom predominantly abstracts the nearest gamma-hydrogen in the molecule.

  DOI：

  10.1107/s0108270199002619
• 作为产物：
  描述：

  N-异丙基马来酰亚胺 、 环戊二烯 生成 exo-N-isopropylbicyclo[2.2.1]hept-2-ene-2,3-dicarboximide
  参考文献：
  名称：

  N-(Isopropyl)norbornane-endo-2,3-dicarboximide

  摘要：

  The geometry of the title molecule, N-isopropylbicyclo-[2.2.1]heptane-endo-2,3-dicarboximide, C12H17NO2, has been confirmed as the endo conformation. The orientation of the isopropyl (Pr-i) group relative to the succinimide moiety is a little unsymmetric and the Pr-i group rotates ca 6 degrees around the N-C bond from the perpendicular configuration. This causes the stereoselectivity of the photoreaction in the solid state. The diastereo-excess of the ring expansion products indicates that the carbonyl-O atom predominantly abstracts the nearest gamma-hydrogen in the molecule.

  DOI：

  10.1107/s0108270199002619

文献信息

• Drug delivery polymers and uses thereof
  申请人：Massachusetts Institute of Technology

  公开号：US10792373B2

  公开（公告）日：2020-10-06

  Described herein are platinum-based brush-arm star polymers (Pt-BASPs), or a pharmaceutical composition thereof, for delivery of platinum-based agents, such as oxaliplatin. Also provided are methods and kits involving the Pt-BASPs, or a pharmaceutical composition thereof, for treating proliferative diseases such as cancers (e.g., lung cancer, head-and-neck cancer, esophagus cancer, stomach cancer, breast cancer, pancreas cancer, colorectal cancer, liver cancer, kidney cancer, or prostate cancer) in a subject.

  本文描述的是铂基刷臂星型聚合物（Pt-BASPs）或其药物组合物，用于递送铂类制剂，如奥沙利铂。还提供了涉及 Pt-BASPs 或其药物组合物的方法和试剂盒，用于治疗受试者的增殖性疾病，如癌症（如肺癌、头颈癌、食道癌、胃癌、乳腺癌、胰腺癌、结直肠癌、肝癌、肾癌或前列腺癌）。
• Degradable polymers of a cyclic silyl ether and uses thereof
  申请人：Massachusetts Institute of Technology

  公开号：US10988491B2

  公开（公告）日：2021-04-27

  The present disclosure provides cyclic silyl ethers of the formula: and salts thereof. The cyclic silyl ethers may be useful as monomers for preparing polymers. Also described herein are polymers prepared by polymerizing a cyclic silyl ether and optionally one or more additional monomers. The polymers may be degradable (e.g., biodegradable). One or more O—Si bonds of the polymers may be the degradation sites. Also described herein are compositions and kits including the cyclic silyl ethers or polymers; methods of preparing the polymers; and methods of using the polymers, compositions, and kits.

  本公开提供了式中的环状硅基醚： 及其盐类。环硅烷醚可用作制备聚合物的单体。本文还描述了通过聚合环硅烷醚和一种或多种附加单体制备的聚合物。这些聚合物可以降解（如可生物降解）。聚合物的一个或多个 O-Si 键可以是降解位点。本文还描述了包括环硅烷醚或聚合物的组合物和试剂盒；制备聚合物的方法；以及使用聚合物、组合物和试剂盒的方法。
• [EN] BRUSH PRODRUGS AND USES THEREOF<br/>[FR] PROMÉDICAMENTS À BROSSE ET LEURS UTILISATIONS
  申请人：MASSACHUSETTS INST TECHNOLOGY

  公开号：WO2019200367A9

  公开（公告）日：2019-12-19
• DRUG DELIVERY POLYMERS AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20170348431A1

  公开（公告）日：2017-12-07

  Described herein are platinum-based brush-arm star polymers (Pt-BASPs), or a pharmaceutical composition thereof, for delivery of platinum-based agents, such as oxaliplatin. Also provided are methods and kits involving the Pt-BASPs, or a pharmaceutical composition thereof, for treating proliferative diseases such as cancers (e.g., lung cancer, head-and-neck cancer, esophagus cancer, stomach cancer, breast cancer, pancreas cancer, colorectal cancer, liver cancer, kidney cancer, or prostate cancer) in a subject.
• BORONIC ESTER PRODRUGS AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20200369685A1

  公开（公告）日：2020-11-26

  Disclosed herein are compounds of Formula (I) or (II). The compounds include an agent (e.g., pharmaceutical agent, cosmetic agent, or nutraceutical agent) through a linker that includes a boronic ester moiety in the backbone of the linker. The compounds may be monomers. Also provided are polymers prepared by polymerizing the monomers. The polymers may be useful for delivering the agent to a subject, tissue, biological sample, or a cell. Also provided are methods of preparing the polymers, compositions and kits comprising the polymers, and methods of use (e.g., use in delivering the agent, treating a disease, preventing a disease, diagnosing a disease) involving the polymers or compositions. The structure of the boronic ester moiety may be fine tuned so that the properties related to delivery to a subject, biological sample, tissue, or cell may be fine tuned.