2-(N,N-diethylanilin-4-yl)-4,6-bis(pyrazol-1-yl)-1,3,5-triazine | 958881-63-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(N,N-diethylanilin-4-yl)-4,6-bis(pyrazol-1-yl)-1,3,5-triazine
• 英文别名: 4-(4,6-di(1H-pyrazol-1-yl)-1,3,5-triazin-2-yl)-N,N-diethylaniline；4-[4,6-di(pyrazol-1-yl)-1,3,5-triazin-2-yl]-N,N-diethylaniline
• CAS: 958881-63-5
• 化学式: C₁₉H₂₀N₈
• 分子量: 360.421
• InChiKey: XYDMMZMUMPAYOW-UHFFFAOYSA-N

物化性质

• 熔点：
  160-163 °C
• 沸点：
  630.4±57.0 °C(predicted)
• 密度：
  1.29±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  77.6
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Yb(2-thenoyltrifluoroacetonate)₃·2H₂O 、 2-(N,N-diethylanilin-4-yl)-4,6-bis(pyrazol-1-yl)-1,3,5-triazine 以 甲醇 为溶剂， 反应 12.0h， 生成
  参考文献：
  名称：

  是敌是友？溶剂在镧系元素（iii）发光的非三重态，配体内电荷转移敏化中的作用†

  摘要：

  在可见和近红外（NIR）区镧系元素发光的致敏达到通过由intraligand电荷转移（ILCT）频带基于二乙氨基-配体系统的长波长激发的非三线态能量传递通路。进行了全面的光物理和溶剂变色研究，以评估我们的Eu（III），Sm（III）和Yb（III）配合物的发光性质。详细研究了溶剂配位和溶剂猝灭对镧系元素发光的影响，并致力于研究Yb（III）敏化的歧义能量转移机理。

  DOI：

  10.1039/c6ra15365h
• 作为产物：
  描述：

  N,N-二乙基苯胺 在 氢化钾 作用下， 以 四氢呋喃 为溶剂， 反应 40.0h， 生成 2-(N,N-diethylanilin-4-yl)-4,6-bis(pyrazol-1-yl)-1,3,5-triazine
  参考文献：
  名称：

  含吡唑并三嗪作为细胞成像染料的两光子激发铱配合物

  摘要：

  在这项工作中，介绍了具有推挽辅助配体的双环金属化铱（III）配合物的合成，稳定性研究和光物理性质。发现该复合物位于线粒体中，并且可以通过共聚焦激光扫描显微镜在双光子激发过程中被激发。

  DOI：

  10.1002/ejic.201800382

文献信息

• Highly Luminescent Sm^III Complexes with Intraligand Charge-Transfer Sensitization and the Effect of Solvent Polarity on Their Luminescent Properties
  作者：Wai-Sum Lo、Junhui Zhang、Wing-Tak Wong、Ga-Lai Law

  DOI：10.1021/acs.inorgchem.5b00331

  日期：2015.4.20

  Samarium complexes with the highest quantum yields to date have been synthesized, and their luminescence properties were studied in 12 solvents. Sensitization via a nontriplet intraligand charge-transfer pathway was also successfully demonstrated in solution states with good quantum yields.

  合成了迄今为止量子产率最高的Sa络合物，并在12种溶剂中研究了它们的发光特性。通过非三重配体内电荷转移途径进行的敏化也已在具有良好量子产率的溶液状态下得到成功证明。
• PHOTOLUMINESCENT NANOPARTICLE, PREPARATION, AND APPLICATION THEREOF
  申请人：Wang Yuan

  公开号：US20130011864A1

  公开（公告）日：2013-01-10

  Luminescent nanoparticles, preparation, and application thereof are disclosed. The luminescent nanoparticle consists of matrix, which is a macromolecular compound containing carboxyl group, and a rare-earth luminescent dye dispersed in the matrix. The preparation method of the luminescent nanoparticle comprises: dissolving the rare-earth complex luminescent dye and the macromolecular compound in organic solvent miscible with water, adding the solution into water, and forming the luminescent nanoparticle by coprecipitation-selfassembly process. The prepared luminescent nanoparticle has excellent long-wave excitational luminescent properties and good stability, and can be used in coupling the surface carboxyl group of a biomolecule. The biological probes based on such luminescent nanoparticles have wide application prospects on the aspects of high-sensitivity luminescent immunoassay, biological imaging and the like.

  本文介绍了荧光纳米颗粒的制备和应用。该荧光纳米颗粒由包含羧基的大分子化合物作为基质，并分散着稀土荧光染料组成。荧光纳米颗粒的制备方法包括将稀土复合荧光染料和大分子化合物溶解在有机溶剂中，加入水中并通过共沉淀自组装过程形成荧光纳米颗粒。制备好的荧光纳米颗粒具有出色的长波激发荧光性能和良好的稳定性，并可用于耦合生物分子表面的羧基。基于这种荧光纳米颗粒的生物探针在高灵敏度荧光免疫分析、生物成像等方面具有广泛的应用前景。
• Polymeric Nanoparticles with Embedded Eu(III) Complexes as Molecular Probes for Temperature Sensing
  作者：Kirill M. Kuznetsov、Vadim A. Baigildin、Anastasia I. Solomatina、Ekaterina E. Galenko、Alexander F. Khlebnikov、Victor V. Sokolov、Sergey P. Tunik、Julia R. Shakirova

  DOI：10.3390/molecules27248813

  日期：——

  Three novel luminescent Eu(III) complexes, Eu1–Eu3, have been synthesized and characterized with CHN analysis, mass-spectrometry and 1H NMR spectroscopy. The complexes display strong emission in dichloromethane solution upon excitation at 405 and 800 nm with a quantum yield from 18.3 to 31.6%, excited-state lifetimes in the range of 243–1016 ms at 20 °C, and lifetime temperature sensitivity of 0.9%/K (Eu1), 1.9%/K (Eu2), and 1.7%/K (Eu3). The chromophores were embedded into biocompatible latex nanoparticles (NPs_Eu1–NPs_Eu3) that prevented emission quenching and kept the photophysical characteristics of emitters unchanged with the highest temperature sensitivity of 1.3%/K (NPs_Eu2). For this probe cytotoxicity, internalization dynamics and localization in CHO-K1 cells were studied together with lifetime vs. temperature calibration in aqueous solution, phosphate buffer, and in a mixture of growth media and fetal bovine serum. The obtained data were then averaged to give the calibration curve, which was further used for temperature estimation in biological samples. The probe was stable in physiological media and displayed good reproducibility in cycling experiments between 20 and 40 °C. PLIM experiments with thermostated CHO-K1 cells incubated with NPs_Eu2 indicated that the probe could be used for temperature estimation in cells including the assessment of temperature variations upon chemical shock (sample treatment with mitochondrial uncoupling reagent).

  我们合成了三种新型发光 Eu（III）配合物 Eu1-Eu3，并利用氯化萘分析、质谱分析和 1H NMR 光谱对其进行了表征。这些配合物在二氯甲烷溶液中受到 405 纳米和 800 纳米波长的激发时会发出强光，量子产率为 18.3% 至 31.6%，在 20 °C 时的激发态寿命为 243-1016 毫秒，寿命温度敏感性分别为 0.9%/K (Eu1)、1.9%/K (Eu2) 和 1.7%/K (Eu3)。将发色团嵌入生物相容性乳胶纳米粒子（NPs_Eu1-NPs_Eu3）中，可防止发射淬灭，并保持发射体的光物理特性不变，温度灵敏度最高为 1.3%/K（NPs_Eu2）。在水溶液、磷酸盐缓冲液以及生长介质和胎牛血清混合物中，研究了该探针在 CHO-K1 细胞中的细胞毒性、内化动力学和定位，以及寿命与温度的校准。然后对获得的数据求平均值，得出校准曲线，并进一步用于生物样本中的温度估算。该探针在生理培养基中很稳定，在 20 至 40 °C的循环实验中显示出良好的重现性。用 NPs_Eu2 培养恒温 CHO-K1 细胞进行的 PLIM 实验表明，该探针可用于细胞温度估计，包括评估化学休克（用线粒体解偶联试剂处理样品）时的温度变化。
• Temporal thermal sensing and related methods
  申请人：C2Sense, Inc.

  公开号：US11513118B2

  公开（公告）日：2022-11-29

  Embodiments described herein generally relate to: sensing and/or authentication using luminescence imaging; diagnostic assays, systems, and related methods; temporal thermal sensing and related methods; and/or to emissive species, such as those excitable by white light, and related systems and methods.

  本文描述的实施方案一般涉及：使用发光成像进行传感和/或认证；诊断测定、系统和相关方法；时间热传感和相关方法；和/或发射物种，例如可被白光激发的物种，以及相关系统和方法。
• Impressive Europium Red Emission Induced by Two-Photon Excitation for Biological Applications
  作者：Wai-Sum Lo、Wai-Ming Kwok、Ga-Lai Law、Chi-Tung Yeung、Chris Tsz-Leung Chan、Ho-Lun Yeung、Hoi-Kuan Kong、Chi-Hang Chen、Margaret B. Murphy、Ka-Leung Wong、Wing-Tak Wong

  DOI：10.1021/ic102465j

  日期：2011.6.20

  Three triazine-based europium(III) complexes were synthesized that demonstrated strong two-photon induced europium emission with a high two-photon absorption cross-section. The modified triazine ligand of complex 3 initiated over 100% enhancement of the two-photon absorption cross-section (sigma(2): 320 GM) when compared with complex 1 (sigma(2): 128 GM) in a solution of DMSO. Europium complex 3 is also stable in vitro, and power-dependence curves were obtained in vitro to confirm the two-photon-induced f-f emission in HeLa cells.