phenoxysulfonyl-acetic acid phenyl ester | 53973-62-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: phenoxysulfonyl-acetic acid phenyl ester
• 英文别名: Phenoxysulfonyl-essigsaeure-phenylester；Phenoxycarbonyl-methan-sulfonsaeure-phenylester；Sulfoessigsaeure-diphenylester；Diphenyl-sulfoacetat；Phenyl 2-phenoxysulfonylacetate
• CAS: 53973-62-9
• 化学式: C₁₄H₁₂O₅S
• 分子量: 292.312
• InChiKey: VDTZAFMWMKDNKU-UHFFFAOYSA-N

物化性质

• 熔点：
  80-81 °C(Solv: benzene (71-43-2); ligroine (8032-32-4))
• 沸点：
  462.7±37.0 °C(Predicted)
• 密度：
  1.350±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  78
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  phenoxysulfonyl-acetic acid phenyl ester 在 氨 作用下， 生成 phenyl carbamoylmethanesulfonate
  参考文献：
  名称：

  Chemistry of the 1,2,4-Thiadiazine Ring System. II. A New Synthesis of 1,2,4,2H-Thiadiazine-3,5(4H,6H)-dione-1,1-dioxide

  摘要：

  DOI：

  10.1021/jo01094a040
• 作为产物：
  描述：

  氯磺酰基乙酰氯 、 苯酚 反应 12.0h， 以92%的产率得到phenoxysulfonyl-acetic acid phenyl ester
  参考文献：
  名称：

  Novel Synthesis of Quinolone-3-sulfonic Acid Derivatives

  摘要：

  DOI：

  10.3987/com-87-4463

文献信息

• Avlessi, Felis'en; Bodina, R. I.; Lipina, E. S., Russian Journal of Organic Chemistry, 1994, vol. 30, # 4, p. 551 - 554
  作者：Avlessi, Felis'en、Bodina, R. I.、Lipina, E. S.、Belova, T. P.、Berkova, G. A.

  DOI：——

  日期：——
• Vieillefosse, Bulletin de la Societe Chimique de France, 1939, vol. <5>6, p. 35
  作者：Vieillefosse

  DOI：——

  日期：——
• (Vinylaryloxy)acetic acids. A new class of diuretic agents. 4. Various [(2-substituted and 2,2-disubstituted vinyl)aryloxy]acetic acids
  作者：Otto W. Woltersdorf、Charles M. Robb、John B. Bicking、L. Sherman Watson、Edward J. Cragoe

  DOI：10.1021/jm00229a024

  日期：1976.7

  A variety of [(2-substituted and 2,2-disubstituted vinyl)aryloxy]acetic acids was synthesized in which the substituents were primarily electron-withdrawing groups. These compounds were tested in dogs for their saluretic and diuretic properties. Many of the compounds exhibited significant activity; however, they were generally less potent than those reported in the three earlier papers in this series.
• 6-Ethyl-1,2,4,2H-thiadiazine-3,5(4H,6H)dione 1,1-Dioxide
  作者：S. Wawzonek、R. L. Abbott

  DOI：10.1021/jm00341a033

  日期：1963.9
• The 1,2,4-Thiadiazine Ring System. III. The Dissociation of 1,2,4,2H-Thiadiazine-3,5(4H,6H)-dione 1,1-Dioxide¹
  作者：R. L. HINMAN、BERNARD E. HOOGENBOOM

  DOI：10.1021/jo01067a105

  日期：1961.9