N-((4-methoxyphenyl)(phenyl)methyl)-4-nitrobenzenesulfonamide | 295360-69-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-((4-methoxyphenyl)(phenyl)methyl)-4-nitrobenzenesulfonamide
• 英文别名: N-[(4-methoxyphenyl)phenyl-methyl]-4-nitrobenzenesulfonamide；N-[(4-methoxyphenyl)-phenylmethyl]-4-nitrobenzenesulfonamide
• CAS: 295360-69-9
• 化学式: C₂₀H₁₈N₂O₅S
• 分子量: 398.439
• InChiKey: LPULIIWVTCZFHV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  110
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-(二甲基苯基硅烷基)苄醇 、 N-[(4-甲氧基苯基)亚甲基]-4-硝基苯磺酰胺 在 [Rh(OH)(cod)]2 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以91%的产率得到N-((4-methoxyphenyl)(phenyl)methyl)-4-nitrobenzenesulfonamide
  参考文献：
  名称：

  Rhodium-catalyzed Addition of Organo[2-(hydroxymethyl)phenyl]dimethylsilanes to Arenesulfonylimines

  摘要：

  该反应发现可以在铑/二烯催化剂的存在下进行。多种取代的二芳基甲基胺和具有N-芳磺酰保护的烯丙胺以良好的产率获得，这些都是有机合成中的重要构建块。

  DOI：

  10.1246/cl.2008.290

文献信息

• A Homogeneous, Recyclable Polymer Support for Rh(I)-Catalyzed C–C Bond Formation
  作者：Ranjan Jana、Jon A. Tunge

  DOI：10.1021/jo201476h

  日期：2011.10.21

  A robust and practical polymer-supported, homogeneous, recyclable biphephos rhodium(I) catalyst has been developed for C-C bond formation reactions. Control of polymer molecular weight allowed tuning of the polymer solubility such that the polymer-supported catalyst is soluble in nonpolar solvents and insoluble in polar solvents. Using the supported rhodium catalysts, addition of aryl and vinylboronic acids to the electrophiles such as enones, aldehydes, N-sulfonyl aldimines, and alkynes occurs smoothly to provide products in high yields. Additions of terminal alkynes to enones and industrially relevant hydroformylation reactions have also been successfully carried out. Studies show that the leaching of Rh from the polymer support is low and catalyst recycle can be achieved by simple precipitation and filtration.
• Rhodium-catalyzed Addition of Organo[2-(hydroxymethyl)phenyl]dimethylsilanes to Arenesulfonylimines
  作者：Yoshiaki Nakao、Masahide Takeda、Jinshui Chen、Tamejiro Hiyama、Yoshitaka Ichikawa、Ryo Shintani、Tamio Hayashi

  DOI：10.1246/cl.2008.290

  日期：2008.3.5

  The title reaction is found to proceed in the presence of a rhodium/diene catalyst. Variously substituted diarylmethylamines and allylamines having an N-arenesulfonyl protection are obtained in good yields, which are important building blocks in organic synthesis.

  该反应发现可以在铑/二烯催化剂的存在下进行。多种取代的二芳基甲基胺和具有N-芳磺酰保护的烯丙胺以良好的产率获得，这些都是有机合成中的重要构建块。