N-Acetoxy-N-(fluorenyl-(1))-acetamid | 22251-02-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: N-Acetoxy-N-(fluorenyl-(1))-acetamid
• 英文别名: n-Acetoxy-acetylaminofluorene；[acetyl(9H-fluoren-1-yl)amino] acetate
• CAS: 22251-02-1
• 化学式: C₁₇H₁₅NO₃
• 分子量: 281.311
• InChiKey: UZPUHZYKPKXPAA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-硝基芴 在 palladium on activated charcoal 吡啶 、 氢气 、 三乙胺 作用下， 生成 N-Acetoxy-N-(fluorenyl-(1))-acetamid
  参考文献：
  名称：

  芴基异羟肟酸与致癌物N-芴-2-基乙酰氧肟酸异构体。的部分I.合成ñ -芴-1-基，ñ -芴-3-基，和Ñ -芴-4- ylacetohydroxamic酸

  摘要：

  通过部分催化还原相应的硝基芴，合成了三种与致癌物N-芴-2-基乙酰氧肟酸同分异构的新芴基异羟肟酸，而相应的硝基芴又是用过氧马来酸氧化相应的芴胺而制得的。探索了一种通过Semmler-Wolff重排将3,4-二氢芴-1（2 H）-肟肟化的方法，制得N（[[ 14 C]芴-1-基）乙酰胺和-乙酰氧肟酸的途径。。通过TLC对产物的分析表明，当在有限量的乙酸酐存在下重排该肟时，亚胺为中间体。

  DOI：

  10.1039/j39690000345

文献信息

• Method for immobilizing biomolecules on metal oxide substrates
  申请人：Wu Ying

  公开号：US20060228813A1

  公开（公告）日：2006-10-12

  The present invention relates to an improved method for providing biomolecules on a metal oxide substrate. In another aspect, the invention relates to a metal oxide substrate, having a surface that is coated with a polymer, said substrate having biomolecules immobilised thereon, wherein said biomolecules are immobilized on said coated surface of said substrate by covalent binding, by means of electromagnetic irradiation. In another aspect, the invention relates to the use of a metal oxide substrate according to the invention for performing probe-based assays.

  本发明涉及一种在金属氧化物基底上提供生物分子的改进方法。另一方面，本发明涉及一种金属氧化物基底，其表面涂有聚合物，所述基底上固定有生物分子，其中所述生物分子通过电磁辐照以共价结合的方式固定在所述基底的涂层表面上。另一方面，本发明涉及根据本发明使用金属氧化物基底进行探针检测。
• PROCEDE FAISANT INTERVENIR UNE SONDE CONTENANT UN ACIDE NUCLEIQUE MODIFIE ET RECONNAISSABLE PAR DES ANTICORPS SPECIFIQUES ET PERMETTANT DE DETECTER ET DE CARACTERISER UNE SEQUENCE D'ADN HOMOLOGUE
  申请人：INSTITUT PASTEUR

  公开号：EP0097664B1

  公开（公告）日：1986-03-12
• Non-nucleotide linking reagents for nucleotide probes
  申请人：GEN-PROBE INCORPORATED

  公开号：EP0313219B1

  公开（公告）日：1996-05-08
• Methods and products for neutralizing the harmful effects of combustion products
  申请人：Tang Moon-Shong

  公开号：US20100196275A1

  公开（公告）日：2010-08-05

  The invention relates to the role of Acr-DNA adducts in p53 mutagenesis in CS-related lung cancer. The distribution of Acr-DNA adducts was mapped at the sequence level in the p53 gene of lung cells using the UvrABC incision method in combination with ligation-mediated PCR. It was determined that Acr preferentially binds at methylated CpG sites. Also, Acr can greatly reduce the DNA repair capacity for damage induced by benzo(a)pyrene diol epoxide. Together these results suggest that Acr is a major etiological agent for CS-related lung cancer and that it contributes to lung carcinogenesis through DNA damage and inhibition of DNA repair. Methods and compositions are provided for either removing an exogenous toxic agent from a combustion product or for preventing the toxic or mutagenic effect of these toxic agents on cells and tissues. Methods are also provided for screening for candidate compounds that protect cells from toxic combustion products.
• US5585481A
  申请人：——

  公开号：US5585481A

  公开（公告）日：1996-12-17