(E)-(4-(4-methylstyryl)phenyl)methanol | 1335205-39-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: (E)-(4-(4-methylstyryl)phenyl)methanol
• 英文别名: (E)-4-(2-(4-methylphenyl)ethenyl)phenylmethanol；[4-[(E)-2-(4-methylphenyl)ethenyl]phenyl]methanol
• CAS: 1335205-39-4
• 化学式: C₁₆H₁₆O
• 分子量: 224.302
• InChiKey: PNZKKMCHMPCHNH-VOTSOKGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (E)-(4-(4-methylstyryl)phenyl)methanol 在 咪唑 、 碘 、 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 以65%的产率得到(E)-1-(iodomethyl)-4-(4-methylstyryl)benzene
  参考文献：
  名称：

  碘催化水与碳-碳σ键的转移加氢

  摘要：

  碘催化水[2.2]对环环烷中苄基CC键的加氢转移，生成4,4'-二甲基联苄。C–Cσ键首先通过碘自由基的均溶取代而裂解，生成4,4'-二碘甲基联苄中间体。此中间体中的苄基C–I键随后被HI还原，HI是由I 2与H 2 O歧化而原位生成的，以实现转移氢化和再生I 2。

  DOI：

  10.1039/c9ob01241a
• 作为产物：
  描述：

  (E)-4-(4-methylstyryl)benzaldehyde 在 sodium tetrahydroborate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 1.0h， 以78%的产率得到(E)-(4-(4-methylstyryl)phenyl)methanol
  参考文献：
  名称：

  碘催化水与碳-碳σ键的转移加氢

  摘要：

  碘催化水[2.2]对环环烷中苄基CC键的加氢转移，生成4,4'-二甲基联苄。C–Cσ键首先通过碘自由基的均溶取代而裂解，生成4,4'-二碘甲基联苄中间体。此中间体中的苄基C–I键随后被HI还原，HI是由I 2与H 2 O歧化而原位生成的，以实现转移氢化和再生I 2。

  DOI：

  10.1039/c9ob01241a

文献信息

• An iterative approach toward the synthesis of discrete oligomeric p-phenylene vinylene organic dyes employing aqueous Wittig chemistry
  作者：James McNulty、David McLeod

  DOI：10.1016/j.tetlet.2011.08.040

  日期：2011.10

  Photovoltaic research has become increasingly prominent as the search for alternatives to fossil fuels are actively sought. A novel process for the iterative synthesis of discrete donor/acceptor-flanked oligostilbenes, key constituents in dye-sensitized solar cells, is described. The aqueous Wittig process is high yielding, proceeds with high (E)-stereoselectivity and allows facile product purification. (C) 2011 Elsevier Ltd. All rights reserved.
• SUBSTITUTED CIS- AND TRANS-STILBENES AS THERAPEUTIC AGENTS
  申请人：STC. UNM

  公开号：US20130178536A1

  公开（公告）日：2013-07-11

  The present invention relates to method(s) of treating a subject afflicted with cancer or a precancerous condition, an inflammatory disease or condition, and/or stroke or other ischemic disease or condition, the method comprising administering to the subject or patient in need a composition comprising a therapeutically effective amount of a substituted cis or trans-stilbene. A method of treating or reducing the likelihood of Alzheimer's disease in a patient is an additional embodiment of the present invention.
• THERAPEUTIC AGENTS FOR SKIN DISEASES AND CONDITIONS
  申请人：STC. UNM

  公开号：US20160287531A1

  公开（公告）日：2016-10-06

  The present invention relates to method(s) of treating a subject afflicted with a skin disease or condition, the method comprising administering to the subject or patient in need a composition comprising a therapeutically effective amount of a substituted cis or trans-stilbene or a stilbene hybrid. A method of treating or reducing the likelihood of a skin disease or condition in a patient is an additional embodiment of the present invention. Preferred pharmaceutical compositions of the invention include nanoemulsions comprising a therapeutically effective amount of a substituted cis or trans-stilbene or stilbene hybrid and at least one antibiotic.
• US9925153B2
  申请人：——

  公开号：US9925153B2

  公开（公告）日：2018-03-27
• Iodine-catalysed transfer hydrogenation of a carbon–carbon σ-bond with water
  作者：Wu Yang、Ching Tat To、Kin Shing Chan

  DOI：10.1039/c9ob01241a

  日期：——

  Iodine catalysed the transfer hydrogenation of a benzylic C–C σ-bond in [2.2]paracyclophane with water to yield 4,4′-dimethylbibenzyl. The C–C σ-bond was first cleaved by homolytic substitution with iodine radicals to produce a 4,4′-diiodomethylbibenzyl intermediate. The benzylic C–I bonds in this intermediate were subsequently reduced by HI, generated in situ from the disproportionation of I2 with

  碘催化水[2.2]对环环烷中苄基CC键的加氢转移，生成4,4'-二甲基联苄。C–Cσ键首先通过碘自由基的均溶取代而裂解，生成4,4'-二碘甲基联苄中间体。此中间体中的苄基C–I键随后被HI还原，HI是由I 2与H 2 O歧化而原位生成的，以实现转移氢化和再生I 2。