喹唑啉-4-羧酸 | 16499-51-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 中文名称: 喹唑啉-4-羧酸
• 英文名称: 4-quinazoline-carboxylic acid
• 英文别名: quinazoline-4-carboxylic acid；Chinazolin-4-carbonsaeure；4-Carboxy-chinazolin
• CAS: 16499-51-7
• 化学式: C₉H₆N₂O₂
• mdl: MFCD09035080
• 分子量: 174.159
• InChiKey: UGTWMWCZTAKZGE-UHFFFAOYSA-N

物化性质

• 沸点：
  399.6±15.0 °C(Predicted)
• 密度：
  1.421±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  喹唑啉-4-羧酸 在 硫酸 、 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 35.0h， 生成 3-hydroxy-1-(quinazolin-4-yl)but-2-en-1-one
  参考文献：
  名称：

  Organometallic compound and organic light-emitting device including the same

  摘要：

  公开号：

  EP2706064B1

文献信息

• Monoacylglycerol Lipase Modulators
  申请人：Janssen Pharmaceutica NV

  公开号：US20200102311A1

  公开（公告）日：2020-04-02

  Bridged compounds of Formula (I) and Formula (II), pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, bipolar disorder), cancers and eye conditions. wherein R 2 , R 3 R 4 , R 5 and R 6 are defined herein.

  桥接化合物，其结构式为(I)和(II)，包含它们的药物组合物，制造它们的方法，以及使用它们的方法，包括用于治疗与MGL调节相关的疾病状态、障碍和状况的方法，如与疼痛、精神障碍、神经障碍（包括但不限于重性抑郁障碍、难治性抑郁、焦虑性抑郁、双相情感障碍）、癌症和眼科疾病相关的方法。 其中R2、R3、R4、R5和R6的定义如下。
• [EN] TETRAHYDROISOQUINOLIN-2-YL-(QUINAZOLIN-4-YL) METHANONE COMPOUNDS AS CANCER CELL GROWTH INHIBITORS<br/>[FR] COMPOSÉS DE TÉTRAHYDROISOQUINOLIN-2-YL-(QUINAZOLIN-4-YL)MÉTHANONE À TITRE D'INHIBITEURS DE CROISSANCE DES CELLULES CANCÉREUSES
  申请人：REXAHN PHARMACEUTICALS INC

  公开号：WO2014143960A1

  公开（公告）日：2014-09-18

  Tetrahydroisoquinolin-2-yl-(quinazolin-4-yl)methanone derivatives represented by formula (I), pharmacologically acceptable salts thereof, and compositions containing such compounds are described. Methods for treating hyperproliferative disorders by administering the compounds are also described. 1,2,3,4-tetrahydroisoquinoline derivatives for making tetrahydroisoquinolin-2-yl-(quinazolin-4-yl)methanone compounds are also described.

  该文描述了由公式（I）表示的以四氢异喹啉-2-基-(喹唑啉-4-基)甲酮衍生物、其药理学上可接受的盐以及含有这些化合物的组合物。还描述了通过给予这些化合物来治疗过度增殖性疾病的方法。还描述了用于制备四氢异喹啉-2-基-(喹唑啉-4-基)甲酮化合物的1,2,3,4-四氢异喹啉衍生物。
• [EN] GLUCOSE TRANSPORT INHIBITORS<br/>[FR] INHIBITEURS DE TRANSPORT DU GLUCOSE
  申请人：BAYER PHARMA AG

  公开号：WO2015091428A1

  公开（公告）日：2015-06-25

  The present invention relates to chemical compounds that selectively inhibit glucose transporter 1 (GLUT1), to methods of preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds, to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, as well as to intermediate compounds useful in the preparation of said compounds.

  本发明涉及选择性抑制葡萄糖转运蛋白1（GLUT1）的化合物，涉及制备该类化合物的方法，包括含有该类化合物的药物组合物和药物组合物，以及利用该类化合物制造用于治疗或预防疾病的药物组合物的用途，还涉及在制备该类化合物中有用的中间体化合物。
• Aroyl-piperidine derivatives
  申请人：Novartis Corporation

  公开号：US05965562A1

  公开（公告）日：1999-10-12

  The invention relates to novel N-(3,5-bis-trifluoromethyl-benzoyl)-2-benzyl-4-(azanaphthoyl-amino)-piperi dines of the formula ##STR1## wherein X and Y are each independently of the other N and/or CH and the ring A is unsubstituted or mono- or poly-substituted by substituents selected from the group consisting of lower alkyl, lower alkoxy, halogen, nitro and trifluoromethyl; and the salts thereof, to the use thereof, to processes for the preparation thereof and to pharmaceutical compositions comprising a compound according to the invention or a pharmaceutically acceptable salt thereof.

  该发明涉及一种新型的N-(3,5-双三氟甲基苯甲酰)-2-苄基-4-(氮杂萘酰基氨基)-哌啶类化合物，其化学式为##STR1##其中X和Y各自独立地为N和/或CH，环A未取代或被从以下群体中选择的取代基单独或多取代，所述取代基包括低烷基、低烷氧基、卤素、硝基和三氟甲基；以及其盐，用途，制备方法和包含根据本发明的化合物或其药学上可接受的盐的制剂。
• Novel compounds for chemiluminescense procedures
  申请人：——

  公开号：US20040214999A1

  公开（公告）日：2004-10-28

  The present invention relates to a chemical compound comprising a light emitting moiety precursor and a precursor of a leaving group, bound to each other by an amide or by an ester bond and characterized in that the leaving group precursor upon oxidation is converted into the leaving group. The invention also relates to compounds additionally comprising a coupling group to the use of such compounds for labeling of biomolecules and more generally to the use of such compounds in chemiluminescence detection procedures.

  本发明涉及一种化学化合物，包括一个发光基团前体和一个离去基团前体的前体，它们通过酰胺或酯键相互结合，并且其特征在于，当离去基团前体氧化时，将转化为离去基团。本发明还涉及化合物，还包括一个偶联基团，用于标记生物分子，更一般地，用于化学发光检测程序中使用这种化合物。