N-glycyl-anthranilic acid | 90557-83-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-glycyl-anthranilic acid
• 英文别名: N-Glycyl-anthranilsaeure；2-Glycylamino-benzoesaeure；2-[(2-Aminoacetyl)amino]benzoic acid
• CAS: 90557-83-8
• 化学式: C₉H₁₀N₂O₃
• 分子量: 194.19
• InChiKey: HZYCLELWSFMAFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  92.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-glycyl-anthranilic acid 在 硫酸 、 potassium nitrate 作用下， 生成 2-glycylamino-4-nitro-benzoic acid
  参考文献：
  名称：

  Balls; Koehler, Chemische Berichte, 1931, vol. 64, p. 34,38

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(2-hydroxyimino-acetylamino)-benzoic acid 在 硫酸 作用下， 生成 N-glycyl-anthranilic acid
  参考文献：
  名称：

  Karrer; Haebler, Helvetica Chimica Acta, 1924, vol. 7, p. 535

  摘要：

  DOI：

文献信息

• α-Aminoacyl derivatives of aminobenzoic acid and of amino-oxy-acids by reaction of their hydrochlorides with amino-acid N-carboxyanhydrides
  作者：Y. Knobler、S. Bittner、D. Virov、Max Frankel

  DOI：10.1039/j39690001821

  日期：——

  The reaction of amino-acid N-carboxyanhydrides with hydrochlorides of aminobenzoic acids and of amino-oxy-acids gave amino-acid amides in a one-step synthesis. The coupling of L-alanine N-carboxyanhydride with anthranilic and with p-aminobenzoic acid hydrochloride gave peptide-like compounds of high optical activity, indicating the presence of little or no racemate. Glycyl and DL-phenylalanyl amides

  氨基酸N-羧基酐与氨基苯甲酸和氨基氧-酸的盐酸盐反应，通过一步合成得到氨基酸酰胺。L-丙氨酸N-羧基酐与邻氨基苯甲酸酯和对氨基苯甲酸盐酸盐的偶合产生具有高光学活性的肽样化合物，表明存在很少或没有外消旋体。以此方式获得了具有氨基苯甲酸的甘氨酰和DL-苯丙氨酰胺，并且通过N-羧基酸酐与对氨基苯甲酰基-L-谷氨酸盐酸盐的反应形成了三聚体。
• [EN] BOMBESIN ANALOG PEPTIDE ANTAGONIST CONJUGATES<br/>[FR] CONJUGUÉS ANTAGONISTES D'UN PEPTIDE DE L'ANALOGUE DE LA BOMBÉSINE
  申请人：UNIVERSITAETSSPITAL BERN

  公开号：WO2009109332A1

  公开（公告）日：2009-09-11

  To provide a diagnostic and therapeutic medicament, a bombesin analog peptide antagonist conjugate is provided which has general Formula (I): [A-(B)n]x-C, wherein A is a metal chelator comprising at least one radionuclide metal, B is a spacer linked to N-terminal of C or a covalent bond and C is a bombesin analog peptide antagonist having a sequence as claimed, where further x is an integer from 1 to 3 and n is an integer from 1 to 6.

  提供一种诊断和治疗药物，该药物是一种炸弹素类似物肽拮抗剂结合物，其具有通式(I)：[A-(B)n]x-C，其中A是至少含有一种放射性核素金属的金属螯合剂，B是连接到C的N末端的间隔物或共价键，C是具有所述序列的炸弹素类似物肽拮抗剂，此外，x是1到3之间的整数，n是1到6之间的整数。
• Use of nanodispersions in cosmetic end formulations
  申请人：Huglin Dietmar

  公开号：US20050191330A1

  公开（公告）日：2005-09-01

  A description is given of the use of a nanodispersion, which comprises (a) a membrane-forming molecule, (b) a coemulsifier and (c) a lipophilic component, in cosmetic end formulation, which nanodispersion is obtainable by (α) mixing the components (a), (b) and (c) until a homogeneous clear liquid is obtained, and (β) adding the liquid obtained in, step (α) to the water phase of the cosmetic end formulations, steps (α) and (β) being carried out without any additional supply of energy. The nanodispersions used according to this invention can be easily prepared and are suitable as carrier systems for a very wide range of cosmetic active agents and oil-soluble dyes.

  本发明描述了一种纳米分散体的使用，包括（a）一种形成膜的分子，（b）一种共乳化剂和（c）一种亲脂性成分，用于化妆品配方中，该纳米分散体可通过（α）混合组分（a）、（b）和（c）直至获得均匀透明液体，以及（β）将步骤（α）中获得的液体添加到化妆品配方的水相中获得，步骤（α）和（β）均不需要额外的能量供应。根据本发明使用的纳米分散体可以很容易地制备，并适用于非常广泛的化妆品活性成分和油溶性染料的载体系统。
• LHRH-II PEPTIDE ANALOGS
  申请人：Linder Karen E.

  公开号：US20120045393A1

  公开（公告）日：2012-02-23

  The invention is directed to analogs of LHRH-II and, more generally, to analogs of the LHRH family in which modifications have been made that confer enhanced binding affinity for LHRH receptors and/or improved metabolic stability. The invention is further directed to methods of targeted therapy and targeted imaging in patients with sex-hormone-related cancers or other LHRH-mediated diseases.

  该发明涉及LHRH-II的类似物，更一般地，涉及LHRH家族的类似物，其中进行了改性以赋予LHRH受体更强的结合亲和力和/或改善代谢稳定性。该发明进一步涉及在患有性激素相关癌症或其他LHRH介导疾病的患者中进行有针对性的治疗和有针对性的成像的方法。
• Bombesin Analog Peptide Antagonist Conjugates
  申请人：Maecke Helmut

  公开号：US20110097266A1

  公开（公告）日：2011-04-28

  To provide a diagnostic and therapeutic medicament, a bombesin analog peptide antagonist conjugate is provided which has general Formula (I), wherein A is a metal chelator comprising at least one radionuclide metal, B is a spacer linked to N-terminal of C or a covalent bond and C is a bombesin analog peptide antagonist having a sequence as claimed, where further x is an integer from 1 to 3 and n is an integer from 1 to 6. [A-(B) n ] x —C  (I)

  提供一种诊断和治疗药物，该药物是一种炸弹素类似物肽拮抗剂共轭物，具有通式（I），其中A是至少含有一种放射性核素金属的金属螯合剂，B是连接到C的N-末端或共价键的间隔物，C是具有所述序列的炸弹素类似物肽拮抗剂，其中x是1到3的整数，n是1到6的整数。[A-(B)n]x—C  (I)