4-甲氧基-7-氮杂吲哚 | 122379-63-9

• 物质功能分类: 医药中间体 - 杂环化合物 - 吡啶类化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 中文名称: 4-甲氧基-7-氮杂吲哚
• 中文别名: 称:4-甲氧基-7-氮杂吲哚；4-甲氧基-7-并环化合物
• 英文名称: 4-methoxy-7-azaindole
• 英文别名: 4-methoxy-1H-pyrrolo[2,3-b]pyridine
• CAS: 122379-63-9
• 化学式: C₈H₈N₂O
• mdl: MFCD08272230
• 分子量: 148.164
• InChiKey: DNIKOOPKCLWWPO-UHFFFAOYSA-N

物化性质

• 沸点：
  399.1±42.0 °C(Predicted)
• 密度：
  1.24±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.125
• 拓扑面积：
  37.9
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险等级：
  IRRITANT
• 危险品标志：
  Xi
• 安全说明：
  S24/25,S26,S39
• 危险类别码：
  R41
• WGK Germany：
  3
• 海关编码：
  2933990090
• 危险类别：
  IRRITANT
• 危险性防范说明：
  P305+P351+P338
• 危险性描述：
  H302,H319

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 4-Methoxy-1h-pyrrolo[2,3-b]pyridine
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 4-Methoxy-1h-pyrrolo[2,3-b]pyridine
CAS number: 122379-63-9

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C8H8N2O
Molecular weight: 148.2

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

应用

4-甲氧基-7-氮杂吲哚可用作有机合成中间体和医药中间体，主要应用于实验室研发及化工生产过程。

反应信息

• 作为反应物：
  描述：

  4-甲氧基-7-氮杂吲哚 生成 methyl 2-{4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl}-2-oxoacetate
  参考文献：
  名称：

  [EN] PROCESS FOR THE PREPARATION OF ANTIVIRAL 7-AZAINDOLE DERIVATIVES
  [FR] PROCEDE DE PREPARATION DE DERIVES ANTIVIRAUX DE 7-AZAINDOLE

  摘要：

  提供了用于制备氮杂吲哌二酰胺衍生物的过程和合成中间体，其化学式为[在此插入化学式]。这些氮杂吲哌二酰胺衍生物等，可用作治疗艾滋病毒和艾滋病的治疗剂。

  公开号：

  WO2003082289A1
• 作为产物：
  描述：

  4-氯-7-氮杂吲哚 生成 4-甲氧基-7-氮杂吲哚
  参考文献：
  名称：

  [EN] PROCESS FOR THE PREPARATION OF ANTIVIRAL 7-AZAINDOLE DERIVATIVES
  [FR] PROCEDE DE PREPARATION DE DERIVES ANTIVIRAUX DE 7-AZAINDOLE

  摘要：

  提供了用于制备氮杂吲哌二酰胺衍生物的过程和合成中间体，其化学式为[在此插入化学式]。这些氮杂吲哌二酰胺衍生物等，可用作治疗艾滋病毒和艾滋病的治疗剂。

  公开号：

  WO2003082289A1

文献信息

• [EN] PYRIMIDINE AND TRIAZINE DERIVATIVES AND THEIR USE AS AXL INHIBITORS<br/>[FR] DÉRIVÉS DE PYRIMIDINE ET DE TRIAZINE, ET LEUR UTILISATION COMME INHIBITEURS D'AXL
  申请人：PFIZER

  公开号：WO2016097918A1

  公开（公告）日：2016-06-23

  Compounds of the general formula(I): (I) processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

  公式(I)的化合物： (I) 这些化合物的制备方法，包含这些化合物的组合物，以及这些化合物的用途。
• Nucleophilic amination of methoxypyridines by a sodium hydride–iodide composite
  作者：Jia Hao Pang、Atsushi Kaga、Shunsuke Chiba

  DOI：10.1039/c8cc05979a

  日期：——

  A new protocol for nucleophilic amination of methoxypyridines and their derivatives was developed using sodium hydride (NaH) in the presence of lithium iodide (LiI). The method offers a concise access to various aminopyridines which are potentially of medicinal interest.

  在碘化锂（LiI）存在下，使用氢化钠（NaH）开发了甲氧基吡啶及其衍生物亲核胺化的新方案。该方法提供了对可能具有医学意义的各种氨基吡啶的简洁途径。
• [EN] BICYCLIC HETEROARYL DERIVATIVES AS ECTONUCLEOTIDE PYROPHOSPHATASE PHOSPHODIESTERASE 1 INHIBITORS<br/>[FR] DÉRIVÉS HÉTÉROARYLE BICYCLIQUES UTILISÉS EN TANT QU'INHIBITEURS DE L'ECTONUCLÉOTIDE PYROPHOSPHATASE/PHOSPHODIESTÉRASE 1
  申请人：RIBOSCIENCE LLC

  公开号：WO2020210649A1

  公开（公告）日：2020-10-15

  The present disclosure provides certain bicyclic heteroaryl compounds that inhibit ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) enzymatic activity and are therefore useful for the treatment of diseases and conditions modulated at least in part by ENPP1. In some embodiments, the bicyclic heteroaryl compounds includes those of Formula (I). Also provided herein are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

  本公开提供了一些抑制细胞外核苷酸焦磷酸酶/磷酸二酯酶1（ENPP1）酶活性的双环杂环芳基化合物，因此对于治疗至少部分受ENPP1调节的疾病和病况是有用的。在某些实施例中，双环杂环芳基化合物包括式（I）中的化合物。本文还提供了含有这类化合物的药物组合物以及制备这类化合物的方法。
• Sequentially Catalyzed Three-Component Masuda–Suzuki–Sonogashira Synthesis of Fluorescent 2-Alkynyl-4-(7-azaindol-3-yl)pyrimidines: Three Palladium-Catalyzed Processes in a One-Pot Fashion
  作者：Thomas J. J. Müller、Daniel Drießen、Lukas Biesen

  DOI：10.1055/s-0040-1707818

  日期：——

  The Masuda–Suzuki–Sonogashira sequence efficiently unites, in a one-pot fashion, a borylation, an arylation, and an alkynylation in the sense of a sequentially Pd-catalyzed three-component reaction to give fluorescent 2-alkynyl-4-(7-azaindol-3-yl) pyrimidines in yields of 24–83% (14 examples). Time-dependent density-functional theory calculations supported the electronic structure of the longest wavelength

  Masuda-Suzuki-Sonogashira 序列以一锅法有效地结合了硼酸化、芳基化和炔基化，在顺序 Pd 催化的三组分反应的意义上，得到荧光 2-炔基-4-(7 -azaindol-3-yl) 嘧啶的产率为 24-83%（14 个实例）。时间相关的密度泛函理论计算支持最长波长吸收带的电子结构，表明这种新型连续三组分合成开辟了有效途径获得炔基 meriolins，一种新型的潜在凋亡诱导剂。
• Site-Selective Functionalization of 7-Azaindoles via Carbene Transfer and Isolation of <i>N</i>-Aromatic Zwitterions
  作者：Junheng Liu、Guangyang Xu、Shengbiao Tang、Qun Chen、Jiangtao Sun

  DOI：10.1021/acs.orglett.0c03653

  日期：2020.12.4

  metal-carbene transfer reaction of 7-azaindoles has been conducted, and the unprecedented dearomative N7-alkylation reaction has been accomplished via ruthenium catalysis. Importantly, through a sequential dearomatization–aromatization process, an isolable, and new class of azaindole-based N-aromatic zwitterions has been discovered from the reaction of 7-azaindoles and diazoesters.

  进行了7-氮杂吲哚的金属-卡宾转移反应的首次系统研究，并且通过钌催化完成了前所未有的脱芳香性N7-烷基化反应。重要的是，通过顺序的脱芳香化-芳香化过程，从7-氮杂吲哚与重氮酸酯的反应中发现了一种可分离的新型基于氮杂吲哚的N-芳香族两性离子。