DND-167 | 101821-61-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: DND-167
• 英文别名: 4,4'-anthracene-9,10-diyldimethyl-bis-morpholine；9,10-bis-morpholinomethyl-anthracene；9,10-Bis-morpholinomethyl-anthracen；DND-167 dye；4-[[10-(morpholin-4-ylmethyl)anthracen-9-yl]methyl]morpholine
• CAS: 101821-61-8
• 化学式: C₂₄H₂₈N₂O₂
• 分子量: 376.499
• InChiKey: VLLFXWZDQHOGLC-UHFFFAOYSA-N

物化性质

• 熔点：
  >250°C
• 溶解度：
  不溶于水；溶于二甲基亚砜
• 最大波长(λmax)：
  373nm

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  24.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  吗啉 、 9,10-二(氯甲基)蒽 生成 DND-167
  参考文献：
  名称：

  Kaplan et al., Zhurnal Obshchei Khimii, 1958, vol. 28, p. 3285,3288; engl. Ausg. S. 3310, 3312

  摘要：

  DOI：

文献信息

• Multifunctional Reference System For Analyte Determinations By Fluorescence
  申请人：Horn Carina

  公开号：US20080014655A1

  公开（公告）日：2008-01-17

  The present invention concerns a system and method for the luminescence detection of an analyte in a liquid sample. The system comprises a support on which an analyte-specific substance and a reference substance are located. The analyte-specific substance is able to emit a first luminescence signal on contact with the analyte and the reference substance is able to emit a second luminescence signal which is substantially quenched by contact with the liquid sample.
• Sequence Specific Fluorescence for Peptide-Fluorochrome Interactions
  申请人：MedChem Imaging

  公开号：US20180120325A1

  公开（公告）日：2018-05-03

  A method of obtaining fluorochromes that bind to specific sites on proteins is presented. The method consists of synthesizing a peptide bearing a sequence from a parent protein and a second peptide of similar composition but with a scrambled sequence. Each peptide is then added to a test fluorochrome at similar concentrations, and a difference in fluorescence is obtained. A difference in fluorescence indicates a sequence dependent interaction between the peptide and fluorochrome. A large number of fluorochromes can be screened using the two peptides to find one binding in a sequence dependent fashion. This fluorochrome can then be tested for binding to the original full-length protein. The fluorochrome can then serve as scaffold in medicinal chemistry. The fluorochrome/peptide interaction and resulting fluorescence can be inhibited by non-fluorescent test compounds, which are compounds that bind to this peptide. Thus. the peptide/fluorochrome interaction can provide assays screening for therapeutic drugs binding to this site on the protein.
• US8759112B2
  申请人：——

  公开号：US8759112B2

  公开（公告）日：2014-06-24
• Kaplan et al., Zhurnal Obshchei Khimii, 1958, vol. 28, p. 3285,3288; engl. Ausg. S. 3310, 3312
  作者：Kaplan et al.

  DOI：——

  日期：——