4-chloro-1-methyl-1,3-dihydro-imidazo[4,5-c]pyridin-2-one | 61719-59-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 4-chloro-1-methyl-1,3-dihydro-imidazo[4,5-c]pyridin-2-one
• 英文别名: 4-chloro-1-methyl-1,3-dihydroimidazo[4,5-c]pyridin-2-one；4-Chlor-1-methylimidazo-<4,5-c>-2-pyridon；4-chloro-1-methyl-3H-imidazo[4,5-c]pyridin-2-one
• CAS: 61719-59-3
• 化学式: C₇H₆ClN₃O
• 分子量: 183.597
• InChiKey: DFVLZIVAHCEZHP-UHFFFAOYSA-N

物化性质

• 密度：
  1.442±0.06 g/cm3(Predicted)
• 溶解度：
  >27.5 [ug/mL]

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  45.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-chloro-1-methyl-1,3-dihydro-imidazo[4,5-c]pyridin-2-one 、 1-溴-2-丁炔 在 potassium carbonate 作用下， 以 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 16.0h， 生成 3-(2-butynyl)-4-chloro-1-methyl-1,3-dihydroimidazo[4,5-c]pyridin-2-one
  参考文献：
  名称：

  EP1568699

  摘要：

  公开号：
• 作为产物：
  描述：

  4-nitro-1-methyl-1,3-dihydro-2H-imidazo<4,5-c>pyridin-2-one 在 盐酸 作用下， 反应 12.0h， 以95%的产率得到4-chloro-1-methyl-1,3-dihydro-imidazo[4,5-c]pyridin-2-one
  参考文献：
  名称：

  Synthesis and properties of 4-haloimidazo[4,5-c]pyridin-2-ones

  摘要：

  DOI：

  10.1007/bf01165030

文献信息

• Imidazopyridine and imidazopyrimidine antiviral agents
  申请人：——

  公开号：US20020016309A1

  公开（公告）日：2002-02-07

  The present invention concerns antiviral compounds, their methods of preparation and their compositions, and use in the treatment of viral infections. More particularly, the invention provides imidazopyridine and imidazopyrimidine derivatives (Formula I) for the treatment of respiratory syncytial virus infection.

  本发明涉及抗病毒化合物，它们的制备方法和组成，以及在治疗病毒感染中的应用。更具体地，本发明提供了咪唑吡啶和咪唑吡嘧啶衍生物（化学式I），用于治疗呼吸道合胞病毒感染。
• 1,3-Dihydroimidazole ring compound
  申请人：Kira Kazunobu

  公开号：US20060111362A1

  公开（公告）日：2006-05-25

  The objective of this invention is to provide novel compounds that show excellent DPPIV-inhibiting activity. The present invention provides compounds represented by the general formula (I), salts thereof, or hydrates thereof, [wherein, T 1 stands for a monocyclic or bicyclic 4 to 12-membered heterocycle having 1 or 2 nitrogen atoms in the ring, which may have substituents; in formula (I), the following formula represents a double bond or a single bond; X 3 denotes an oxygen atom or a sulfur atom; X 1 denotes a C 2-6 alkyl group which may have substituents; Z 1 denotes a nitrogen atom or the formula —CR 3 ═; Z 2 and Z 3 each independently denote a nitrogen atom, the formula —CR 1 ═, a carbonyl group, or the formula —NR 2 —; R 1 , R 2 , R 3 , and X 2 each independently denote a C 1-6 alkyl group which may have substituents, and such].

  本发明的目的是提供新型化合物，具有出色的DPPIV抑制活性。本发明提供一般式（I）所表示的化合物、其盐或水合物，其中，T1代表一个单环或双环4至12元杂环，环中有1或2个氮原子，可以有取代基；在公式（I）中，以下式表示双键或单键；X3表示氧原子或硫原子；X1表示C2-6烷基，可以有取代基；Z1表示氮原子或式—CR3═；Z2和Z3各自独立地表示氮原子、式—CR1═、羰基或式—NR2—；R1、R2、R3和X2各自独立地表示C1-6烷基，可以有取代基。
• Fused 1,3-dihydro-imidazole ring compounds
  申请人：Eisai R&D Management Co., Ltd.

  公开号：US07524847B2

  公开（公告）日：2009-04-28

  The objective of this invention is to provide novel compounds that show excellent DPPIV-inhibiting activity. The present invention provides compounds represented by the general formula (I), salts thereof, or hydrates thereof, [wherein, T1 stands for a monocyclic or bicyclic 4 to 12-membered heterocycle having 1 or 2 nitrogen atoms in the ring, which may have substituents; in formula (I), the following formula represents a double bond or a single bond; X3 denotes an oxygen atom or a sulfur atom; X1 denotes a C2-6 alkyl group which may have substituents; Z1 denotes a nitrogen atom or the formula —CR3=; Z2 and Z3 each independently denote a nitrogen atom, the formula —CR1=, a carbonyl group, or the formula —NR2—; R1, R2, R3, and X2 each independently denote a C1-6 alkyl group which may have substituents, and such].

  本发明的目的是提供具有出色的DPPIV抑制活性的新化合物。本发明提供了由通式（I）表示的化合物，其盐或水合物，其中，T1代表具有1或2个氮原子的单环或双环4到12成员杂环，该环可能具有取代基；在式（I）中，以下式表示双键或单键；X3表示氧原子或硫原子；X1表示C2-6烷基，该烷基可能具有取代基；Z1表示氮原子或公式—CR3=；Z2和Z3各自独立地表示氮原子，公式—CR1=，羰基或公式—NR2—；R1、R2、R3和X2各自独立地表示C1-6烷基，该烷基可能具有取代基。
• 1,3-DIHYDROIMIDAZOLE FUSED-RING COMPOUND
  申请人：Eisai Co., Ltd.

  公开号：EP1568699A1

  公开（公告）日：2005-08-31

  The objective of this invention is to provide novel compounds that show excellent DPPIV-inhibiting activity. The present invention provides compounds represented by the general formula (I), salts thereof, or hydrates thereof, [wherein, T1 stands for a monocyclic or bicyclic 4 to 12-membered heterocycle having 1 or 2 nitrogen atoms in the ring, which may have substituents; in formula (I), the following formula represents a double bond or a single bond; X3 denotes an oxygen atom or a sulfur atom; X1 denotes a C2-6 alkynyl group which may have substituents; Z1 denotes a nitrogen atom or the formula -CR3=; Z2 and Z3 each independently denote a nitrogen atom, the formula -CR1=, a carbonyl group, or the formula -NR2-; R1, R2, R3, and X2 each independently denote a C1-6 alkyl group which may have substituents, and such].

  本发明的目的是提供具有优异的 DPPIV 抑制活性的新型化合物。本发明提供了通式（I）所代表的化合物、其盐类或其水合物、 其中 T1 代表环中有 1 或 2 个氮原子的单环或双环 4 至 12 元杂环，该杂环可以有取代基；在式（I）中，下式 表示双键或单键；X3 表示氧原子或硫原子；X1 表示可能具有取代基的 C2-6 烷基；Z1 表示氮原子或式-CR3=；Z2 和 Z3 各自独立地表示氮原子、式-CR1=、羰基或式-NR2-；R1、R2、R3 和 X2 各自独立地表示可能具有取代基的 C1-6 烷基，等等]。
• US6489338B2
  申请人：——

  公开号：US6489338B2

  公开（公告）日：2002-12-03