9-(4-iodophenyl)nonan | 1359844-16-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 9-(4-iodophenyl)nonan
• 英文别名: 1-Iodo-4-nonylbenzene
• CAS: 1359844-16-8
• 化学式: C₁₅H₂₃I
• 分子量: 330.252
• InChiKey: YQJZTJODVGPWSI-UHFFFAOYSA-N

物化性质

• 沸点：
  334.9±11.0 °C(Predicted)
• 密度：
  1.270±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.8
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  9-(4-iodophenyl)nonan 在 2-双环己基膦-2',6'-二甲氧基联苯 、 potassium hydrogen fluoride 、 palladium diacetate 、 三乙胺 作用下， 以 1,4-二氧六环 、 甲醇 、 水 为溶剂， 反应 1.5h， 生成 4-壬基苯硼酸
  参考文献：
  名称：

  Design and synthesis of boronic acid inhibitors of endothelial lipase

  摘要：

  Endothelial lipase (EL) and lipoprotein lipase (LPL) are homologous lipases that act on plasma lipoproteins. EL is predominantly a phospholipase and appears to be a key regulator of plasma HDL-C. LPL is mainly a triglyceride lipase regulating (V)LDL levels. The existing biological data indicate that inhibitors selective for EL over LPL should have anti-atherogenic activity, mainly through increasing plasma HDL-C levels. We report here the synthesis of alkyl, aryl, or acyl-substituted phenylboronic acids that inhibit EL. Many of the inhibitors evaluated proved to be nearly equally potent against both EL and LPL, but several exhibited moderate to good selectivity for EL. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.12.043
• 作为产物：
  描述：

  p-壬基苯胺 在 盐酸 、 sodium nitrite 、 potassium iodide 作用下， 以 水 为溶剂， 生成 9-(4-iodophenyl)nonan
  参考文献：
  名称：

  Design and synthesis of boronic acid inhibitors of endothelial lipase

  摘要：

  Endothelial lipase (EL) and lipoprotein lipase (LPL) are homologous lipases that act on plasma lipoproteins. EL is predominantly a phospholipase and appears to be a key regulator of plasma HDL-C. LPL is mainly a triglyceride lipase regulating (V)LDL levels. The existing biological data indicate that inhibitors selective for EL over LPL should have anti-atherogenic activity, mainly through increasing plasma HDL-C levels. We report here the synthesis of alkyl, aryl, or acyl-substituted phenylboronic acids that inhibit EL. Many of the inhibitors evaluated proved to be nearly equally potent against both EL and LPL, but several exhibited moderate to good selectivity for EL. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.12.043

文献信息

• Modified cellular substrates used as linkers for increased cell retention of diagnostic and therapeutic agents
  申请人：NEORX CORPORATION

  公开号：EP0336364A2

  公开（公告）日：1989-10-11

  Modified cellular substrates are used as linking groups that are recognized as cellular substrates by intracellular metabolic enzymes. The linking groups function to attach a ligand, such as a drug or radionuclide, to a targeting protein, such as an antibody or antibody fragment. The false substrate structure of the linking groups causes increased cellular retention of the linking group/ligand conjugate because the enzymes used for catabolism of the substrate are inhibited by the false substrate structure of the linking group.

  经修饰的细胞底物可用作连接基团，被细胞内代谢酶识别为细胞底物。连接基团的作用是将配体（如药物或放射性核素）连接到靶向蛋白（如抗体或抗体片段）上。连接基团的假底物结构可增加细胞对连接基团/配体共轭物的保留，因为用于分解底物的酶受到连接基团假底物结构的抑制。
• RESIN FILM FOR ULTRAVIOLET-CURABLE INKJET PRINTING, AND PRINTED MATTER RESULTING FROM PRINTING BEING APPLIED TO SAID FILM
  申请人：Yupo Corporation

  公开号：EP2517890B1

  公开（公告）日：2019-05-15