3-(5-Hydroxypentylamino)-1-propyl-[1]benzothiolo[2,3-b]pyrazin-2-one | 181299-22-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 3-(5-Hydroxypentylamino)-1-propyl-[1]benzothiolo[2,3-b]pyrazin-2-one
• CAS: 181299-22-9
• 化学式: C₁₈H₂₃N₃O₂S
• 分子量: 345.466
• InChiKey: QRANNCOVNRMJLC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  93.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(5-Hydroxypentylamino)-1-propyl-[1]benzothiolo[2,3-b]pyrazin-2-one 在 氯化亚砜 作用下， 以 氯仿 为溶剂， 反应 1.0h， 以47.6%的产率得到3-(5-Chloro-pentylamino)-1-propyl-1H-benzo[4,5]thieno[2,3-b]pyrazin-2-one
  参考文献：
  名称：

  Synthesis of 1-alkyl-3-dialkylaminoalkylamine[1]benzo-thieno[2,3-b]pyrazin-2(1H))-ones and their ability to antagonize KCl-induced contractions

  摘要：

  A series of 1-alkyl-3-dialkylaminoalkylamino[1]benzothieno[2,3-b]pyrazin-2(1H)-ones 5-35 was synthesized. Some of these compounds showed appreciable inhibition towards KCl-induced contractions in isolated rat aortic rings. The results obtained showed that, although this activity appears at higher concentrations than with caroverine, used as reference standard, this new tricyclic system could be considered as a nucleus with potential calcium antagonistic activity.

  DOI：

  10.1016/0223-5234(96)89556-0
• 作为产物：
  描述：

  1-propyl-4H-[1]benzothiolo[2,3-b]pyrazine-2,3-dione 在 氯化亚砜 作用下， 以 甲苯 为溶剂， 反应 2.0h， 生成 3-(5-Hydroxypentylamino)-1-propyl-[1]benzothiolo[2,3-b]pyrazin-2-one
  参考文献：
  名称：

  Synthesis of 1-alkyl-3-dialkylaminoalkylamine[1]benzo-thieno[2,3-b]pyrazin-2(1H))-ones and their ability to antagonize KCl-induced contractions

  摘要：

  A series of 1-alkyl-3-dialkylaminoalkylamino[1]benzothieno[2,3-b]pyrazin-2(1H)-ones 5-35 was synthesized. Some of these compounds showed appreciable inhibition towards KCl-induced contractions in isolated rat aortic rings. The results obtained showed that, although this activity appears at higher concentrations than with caroverine, used as reference standard, this new tricyclic system could be considered as a nucleus with potential calcium antagonistic activity.

  DOI：

  10.1016/0223-5234(96)89556-0

文献信息

• Synthesis of 1-alkyl-3-dialkylaminoalkylamine[1]benzo-thieno[2,3-b]pyrazin-2(1H))-ones and their ability to antagonize KCl-induced contractions
  作者：F Guerrera、L Salerno、MC Sarva、MA Siracusa、A Rescifina、R Scalia、A Bianchi

  DOI：10.1016/0223-5234(96)89556-0

  日期：1996.1

  A series of 1-alkyl-3-dialkylaminoalkylamino[1]benzothieno[2,3-b]pyrazin-2(1H)-ones 5-35 was synthesized. Some of these compounds showed appreciable inhibition towards KCl-induced contractions in isolated rat aortic rings. The results obtained showed that, although this activity appears at higher concentrations than with caroverine, used as reference standard, this new tricyclic system could be considered as a nucleus with potential calcium antagonistic activity.