N-(2-methoxyethyl)-N-methylpyrazin-2-amine | 1217067-88-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-(2-methoxyethyl)-N-methylpyrazin-2-amine
• CAS: 1217067-88-3
• 化学式: C₈H₁₃N₃O
• 分子量: 167.211
• InChiKey: CSOWPBQKPBSHQM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.56
• 重原子数：
  12.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  38.25
• 氢给体数：
  0.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  N-(2-methoxyethyl)-N-methylpyrazin-2-amine 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 二甲基亚砜 为溶剂， 生成 3,5-dibromo-N-(2-methoxyethyl)-N-methylpyrazin-2-amine
  参考文献：
  名称：

  2,3-Diaminopyrazines as rho kinase inhibitors

  摘要：

  Inhibition of rho kinase ( ROCK) has been recognized as an important target for a number of diseases, including glaucoma. Herein we report SAR development around two hits from a kinase library that led to the discovery of the ROCK inhibitor compound 38. In vitro and in vivo analysis of this compound, including its effects in a monkey model of glaucoma will be discussed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.12.012
• 作为产物：
  描述：

  2-氯吡嗪 、 N-(2-甲氧基乙基)甲基胺 以 二甲基亚砜 为溶剂， 生成 N-(2-methoxyethyl)-N-methylpyrazin-2-amine
  参考文献：
  名称：

  2,3-Diaminopyrazines as rho kinase inhibitors

  摘要：

  Inhibition of rho kinase ( ROCK) has been recognized as an important target for a number of diseases, including glaucoma. Herein we report SAR development around two hits from a kinase library that led to the discovery of the ROCK inhibitor compound 38. In vitro and in vivo analysis of this compound, including its effects in a monkey model of glaucoma will be discussed. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.12.012