2-methylsulfanyl-4-phenyl-4,5-dihydro-thiazole | 909201-76-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methylsulfanyl-4-phenyl-4,5-dihydro-thiazole
• 英文别名: 2-Methylsulfanyl-4-phenyl-4,5-dihydrothiazole；2-methylsulfanyl-4-phenyl-4,5-dihydro-1,3-thiazole
• CAS: 909201-76-9
• 化学式: C₁₀H₁₁NS₂
• 分子量: 209.336
• InChiKey: XFLWFNGULCPZSB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  63
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-methylsulfanyl-4-phenyl-4,5-dihydro-thiazole 在 氯化铵 作用下， 以 乙醇 为溶剂， 生成 4-phenyl-4,5-dihydro-1,3-thiazol-2-amine
  参考文献：
  名称：

  Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase

  摘要：

  Syntheses and evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase (NOS) are discussed. An extensive SAR was established for pyrrolidin-2-imines class of compounds. The amidines came out as the most potent inhibitors in addition to displaying selectivity. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.06.033
• 作为产物：
  描述：

  重氮甲烷 、 4-苯基噻唑啉-2-硫酮 生成 2-methylsulfanyl-4-phenyl-4,5-dihydro-thiazole
  参考文献：
  名称：

  Bafford,R.A. et al., Bulletin de la Societe Chimique de France, 1973, p. 971 - 977

  摘要：

  DOI：

文献信息

• Muscarinic agonists
  申请人：Allen Rebecca Jennifer

  公开号：US20060154922A1

  公开（公告）日：2006-07-13

  The present invention relates to compounds of Formula (I): which are agonists of the M-1 muscarinic receptor.

  本发明涉及公式（I）的化合物，其是M-1肌动蛋白受体的激动剂。
• Bafford,R.A. et al., Bulletin de la Societe Chimique de France, 1973, p. 971 - 977
  作者：Bafford,R.A. et al.

  DOI：——

  日期：——
• Evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase
  作者：K Shankaran、Karla L Donnelly、Shrenik K Shah、Ravindra N Guthikonda、Malcolm MacCoss、John L Humes、Stephen G Pacholok、Stephan K Grant、T.M Kelly、K.K Wong

  DOI：10.1016/j.bmcl.2004.06.033

  日期：2004.9

  Syntheses and evaluation of pyrrolidin-2-imines and 1,3-thiazolidin-2-imines as inhibitors of nitric oxide synthase (NOS) are discussed. An extensive SAR was established for pyrrolidin-2-imines class of compounds. The amidines came out as the most potent inhibitors in addition to displaying selectivity. (C) 2004 Elsevier Ltd. All rights reserved.