2,3-methylenedioxycinnamaldehyde | 119491-07-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂醛
• 英文名称: 2,3-methylenedioxycinnamaldehyde
• 英文别名: 3-(2,3-methylenedioxyphenyl)acrylaldehyde；(E)-3-(1,3-benzodioxol-4-yl)prop-2-enal
• CAS: 119491-07-5
• 化学式: C₁₀H₈O₃
• 分子量: 176.172
• InChiKey: PVKGKJCLDNGUEQ-DUXPYHPUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,3-methylenedioxycinnamaldehyde 、 二乙氧基磷酰乙醛甲苯磺酰腙 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 反应 2.25h， 以60%的产率得到3(5)-[2-(2,3-methylenedioxyphenyl)vinyl]-1H-pyrazole
  参考文献：
  名称：

  [EN] PYRAZOLE DERIVATIVES MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY
  [FR] MODULATEURS A PETITES MOLECULES DE L'ACTIVITE DU FACTEUR DE CROISSANCE D'HEPATOCYTE (FACTEUR DE DISPERSION)

  摘要：

  公开号：

  WO2004058721A3
• 作为产物：
  描述：

  2,3-(亚甲二氧基)苯甲醛 、 2,2-Bis(trimethylsilyl)acetaldehyd-(tert-butyl)aldimin 在 zinc dibromide 、 水 、 zinc(II) chloride 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 1.0h， 生成 2,3-methylenedioxycinnamaldehyde
  参考文献：
  名称：

  [EN] PYRAZOLE DERIVATIVES MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY
  [FR] MODULATEURS A PETITES MOLECULES DE L'ACTIVITE DU FACTEUR DE CROISSANCE D'HEPATOCYTE (FACTEUR DE DISPERSION)

  摘要：

  公开号：

  WO2004058721A3

文献信息

• METHODS AND COMPOSITIONS OF SMALL MOLECULE MODULATORS OF HEPATOCYTE GROWTH FACTOR (SCATTER FACTOR) ACTIVITY
  申请人：Angion Biomedica Corp.

  公开号：US20180009793A1

  公开（公告）日：2018-01-11

  The present invention provides compositions and formulations of compounds having formula (I) and pharmaceutically acceptable derivatives thereof, wherein p, R 1 , R 2 and B are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of injuries, conditions or diseases in which HGF/SF or the activities thereof, or agonists or antagonists thereof have a therapeutically useful role. In addition, methods are provided for treating such diseases or diseases starting at a time after the onset of the injury, condition or disease.

  本发明提供具有公式（I）及其药学上可接受的衍生物的组合物和配方，其中p，R1，R2和B如本文中一般和在类和子类中所述，并提供其制药组合物以及使用它们治疗HGF/SF或其活性或其激动剂或拮抗剂在治疗中有治疗用途的任何损伤，疾病或疾病的方法。此外，还提供了治疗这些疾病或在损伤，疾病或疾病发病后的时间开始治疗的方法。
• Asymmetric Ion Pair Catalysis of 6π Electrocyclizations: Brønsted Acid Catalyzed Enantioselective Synthesis of Optically Active 1,4-Dihydropyridazines
  作者：Arindam Das、Chandra M. R. Volla、Iuliana Atodiresei、Wolfgang Bettray、Magnus Rueping

  DOI：10.1002/anie.201301638

  日期：2013.7.29

  Electric slide: Described is a general, operationally simple, highly enantioselective Brønsted acid catalyzed condensation/6π‐electrocyclization reaction between hydrazones and α,β‐unsaturated aldehydes that yields valuable 1,4‐dihydropyridazines. The reaction exhibits high tolerance towards functional groups and affords products with up to 98 % ee.

  电动滑片：描述了与α，β-不饱和醛之间的一般，操作简单，高度对映选择性的布朗斯台德酸催化缩合/6π-电环化反应，产生有价值的1,4-二氢哒嗪。该反应表现出对官能团的高度耐受性，并提供具有高达98％ee的产物。
• Small molecule modulators of hepatocyte growth factor (scatter factor) activity
  申请人：Zembower E. David

  公开号：US20050113369A1

  公开（公告）日：2005-05-26

  The present invention provides compounds having formula (1): and pharmaceutically acceptable derivatives thereof, wherein R 1 , R 2 and B are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of conditions or diseases in which HGF/SF or the activities thereof, or agonists or antagonists thereof have a therapeutically useful role.

  本发明提供具有公式（1）的化合物及其药学上可接受的衍生物，其中R1、R2和B如本文中一般和在各类和亚类中所述，并且还提供了它们的药物组合物，以及使用它们治疗HGF/SF或其活性或其激动剂或拮抗剂在治疗上有治疗作用的任何一种疾病或病症的方法。
• Methods and compositions of small molecule modulators of hepatocyte growth factor (scatter factor) activity
  申请人：ANGION BIOMEDICA CORP.

  公开号：US10899750B2

  公开（公告）日：2021-01-26

  The present invention provides compositions and formulations of compounds having formula (I): and pharmaceutically acceptable derivatives thereof, wherein p, R1, R2 and B are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof for the treatment of any of a number of injuries, conditions or diseases in which HGF/SF or the activities thereof, or agonists or antagonists thereof have a therapeutically useful role. In addition, methods are provided for treating such diseases or diseases starting at a time after the onset of the injury, condition or disease.

  本发明提供了具有式(I)：的化合物及其药学上可接受的衍生物的组合物和制剂，其中p、R1、R2和B如本文一般和类及亚类中所述，此外还提供了其药物组合物，以及使用其治疗HGF/SF或其活性或其激动剂或拮抗剂具有治疗作用的多种损伤、病症或疾病中任何一种的方法。 此外，还提供了在损伤、病症或疾病发生后开始治疗此类疾病的方法。
• Oxidative Coupling of Benzenes with α,β-Unsaturated Aldehydes by the Pd(OAc)₂/Molybdovanadophosphoric Acid/O₂ System
  作者：Tomoyuki Yamada、Satoshi Sakaguchi、Yasutaka Ishii

  DOI：10.1021/jo050534o

  日期：2005.7.1

  The oxidative coupling reaction of benzene with an (x,P-unsaturated aldehyde was examined by the combined catalytic system of Pd(OAc)(2) with molybdovanadophosphoric acid (HPMoV) under atmospheric dioxygen. Thus, the reaction of benzene with acrolein under dioxygen (1 atm) by the use of catalytic amounts of Pd(OAc)(2) and H4PMo11VO40 (.) 26H(2)O in the presence of dibenzoylmethane as, a ligand in propionic acid at 90 degrees C for 1.5 h afforded cinnamaldehyde in 59% yield and beta-phenyleinnamaldehyde in 5% yield. This catalytic system was extended to the direct oxidative coupling through the C-H bond activation of various arenes with acrolein and methacrolein.