butyl-4-tosylpiperazine | 107785-36-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: butyl-4-tosylpiperazine
• 英文别名: 1-Butyl-4-(4-methylphenyl)sulfonylpiperazine
• CAS: 107785-36-4
• 化学式: C₁₅H₂₄N₂O₂S
• 分子量: 296.434
• InChiKey: GQSWHRYSJZJYCG-UHFFFAOYSA-N

物化性质

• 沸点：
  415.4±55.0 °C(Predicted)
• 密度：
  1.128±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  49
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  toluene sulfonyl chloride 在 potassium carbonate 、 三乙胺 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 12.0h， 生成 butyl-4-tosylpiperazine
  参考文献：
  名称：

  One-Step Cyclization: Synthesis of N-Heteroalkyl-N′-tosylpiperazines

  摘要：

  Piperazine derivatives are important intermediates in organic synthesis and useful building blocks in pharmaceutical and fine chemical industries. Currently available synthetic routes for these heterocyclic compounds have limited scope owing to the harsh reaction conditions, low yields, and multistep process. Herein, we reported a practical method for synthesis of alkyl-, alcohol-, amine-, and ester-extended tosylpiperazines under mild conditions with moderate to high yields. This protocol exhibits potential applicability in the synthesis of pharmaceuticals and natural products because of the operational simplicity and the conveniently available reactants. On the basis of the experimental and theoretical results, a plausible mechanism of aliphatic nucleophilic substitution (S-N) in the cyclization has been postulated and evidence for the formation of a six-membered ring has also been confirmed by means of density functional theory (DFT) calculations.

  DOI：

  10.1021/jo3012896

文献信息

• Decolorizable ink composition and ink jet printer using the ink composition
  申请人：Ricoh Company, Ltd.

  公开号：EP1149877A1

  公开（公告）日：2001-10-31

  In an ink composition, a coloring agent, a color developer, and a decolorization agent are dissolved or dispersed in a solvent. The ink is capable of being colored at 40°C or less, with the coloring agent reacting with the color developer to form a bonded structure, and also capable of being decolorized when heated to 100°C or more, with the bonded structure being ruptured to liberate the color developer therefrom, and the liberated color developer being chemically bonded to the decolorization agent. An ink jet printer is provided with a paper feeder for feeding a recording sheet for ink jet printing, a recorder for recording an ink image on the recording sheet fed from the paper feeder using the above-mentioned ink composition, and a paper discharger for discharging the recording sheet from the ink jet printer. By further providing an eraser, the ink image recorded on the recording sheet by the recorder can be erased, thereby achieving recycling of the recording sheet.

  在一种油墨组合物中，着色剂、显色剂和脱色剂溶解或分散在溶剂中。这种墨水能在 40°C 或更低温度下着色，着色剂与显色剂反应形成粘合结构，也能在加热到 100°C 或更高温度时脱色，粘合结构破裂，显色剂从中释放出来，释放出来的显色剂与脱色剂化学粘合。喷墨打印机具有送纸器，用于送入用于喷墨打印的记录纸；记录器，用于使用上述墨水成分在从送纸器送入的记录纸上记录墨水图像；以及排纸器，用于将记录纸从喷墨打印机中排出。通过进一步提供一个擦除器，记录器记录在记录纸上的墨水图像可以被擦除，从而实现记录纸的循环利用。
• US6527384B2
  申请人：——

  公开号：US6527384B2

  公开（公告）日：2003-03-04
• US8894970B2
  申请人：——

  公开号：US8894970B2

  公开（公告）日：2014-11-25
• One-Step Cyclization: Synthesis of <i>N</i>-Heteroalkyl-<i>N</i>′-tosylpiperazines
  作者：Jianying Huang、Weiyuan Xu、Hujun Xie、Shijun Li

  DOI：10.1021/jo3012896

  日期：2012.9.7

  Piperazine derivatives are important intermediates in organic synthesis and useful building blocks in pharmaceutical and fine chemical industries. Currently available synthetic routes for these heterocyclic compounds have limited scope owing to the harsh reaction conditions, low yields, and multistep process. Herein, we reported a practical method for synthesis of alkyl-, alcohol-, amine-, and ester-extended tosylpiperazines under mild conditions with moderate to high yields. This protocol exhibits potential applicability in the synthesis of pharmaceuticals and natural products because of the operational simplicity and the conveniently available reactants. On the basis of the experimental and theoretical results, a plausible mechanism of aliphatic nucleophilic substitution (S-N) in the cyclization has been postulated and evidence for the formation of a six-membered ring has also been confirmed by means of density functional theory (DFT) calculations.