6-(2-amino-ethylamino)-hexan-1-ol | 171610-02-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 6-(2-amino-ethylamino)-hexan-1-ol
• 英文别名: 6-(2-Aminoethylamino)hexan-1-ol
• CAS: 171610-02-9
• 化学式: C₈H₂₀N₂O
• 分子量: 160.26
• InChiKey: PTWPIXUHAIQTNZ-UHFFFAOYSA-N

物化性质

• 沸点：
  284.9±20.0 °C(Predicted)
• 密度：
  0.939±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  11
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.3
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-(2-amino-ethylamino)-hexan-1-ol 在 sodium hydride 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 2.5h， 生成 (2-tert-butoxycarbonylamino-ethyl)-(6-oxo-hexyl)-carbamic acid tert-butyl ester
  参考文献：
  名称：

  New Approach for the Preparation of Efficient DNA Cleaving Agents:  Ditopic Copper−Platinum Complexes Based on 3-Clip-Phen and Cisplatin

  摘要：

  The design and synthesis of new heterodinuclear DNA-targeting agents are described. The abilities of cisplatin and Cu(3-Clip-Phen) [Cu(1-(1,10-phenanthrolin-3-yloxy)-3-(1,10-phenanthrolin-8-yloxy)propan-2-amine)Cl-2], an artificial DNA-cleaving agent, have been combined through their "covalent coupling". This strategy has led to bifunctional complexes that are able to cleave the DNA in a double-stranded fashion in contrast to Cu(3-Clip-Phen) alone and have promising cytotoxicities compared to cisplatin in several cell lines.

  DOI：

  10.1021/jm0614331
• 作为产物：
  描述：

  6-溴正己醇 、 乙二胺 反应 3.0h， 以85%的产率得到6-(2-amino-ethylamino)-hexan-1-ol
  参考文献：
  名称：

  New Approach for the Preparation of Efficient DNA Cleaving Agents:  Ditopic Copper−Platinum Complexes Based on 3-Clip-Phen and Cisplatin

  摘要：

  The design and synthesis of new heterodinuclear DNA-targeting agents are described. The abilities of cisplatin and Cu(3-Clip-Phen) [Cu(1-(1,10-phenanthrolin-3-yloxy)-3-(1,10-phenanthrolin-8-yloxy)propan-2-amine)Cl-2], an artificial DNA-cleaving agent, have been combined through their "covalent coupling". This strategy has led to bifunctional complexes that are able to cleave the DNA in a double-stranded fashion in contrast to Cu(3-Clip-Phen) alone and have promising cytotoxicities compared to cisplatin in several cell lines.

  DOI：

  10.1021/jm0614331

文献信息

• A COMPOSITION FOR USE IN WASHING AND CLEANSING VULCANIZATION MOLDS
  申请人：SAN MARTINO S.P.A.

  公开号：EP0576445B1

  公开（公告）日：1996-05-15
• SYNERGISTIC PERFORMANCE OF AMINE BLENDS IN SHALE CONTROL
  申请人：Huntsman Petrochemical LLC

  公开号：EP3986977A1

  公开（公告）日：2022-04-27
• US5468422A
  申请人：——

  公开号：US5468422A

  公开（公告）日：1995-11-21
• [EN] A COMPOSITION FOR USE IN WASHING AND CLEANSING VULCANIZATION MOLDS
  申请人：SILVANI ANTINCENDI S.P.A

  公开号：WO1992016346A1

  公开（公告）日：1992-10-01

  (EN) The new composition for use in washing and cleansing vulcanization molds in the manufacture of tyres or other rubber items comprises: a) 10 to 90 % of an amine or an amine mixture; b) 2 to 20 % of a nonionic or anionic surface-active agent or a surface-active agent mixture; and c) 90 to 10 % of a solvent.(FR) Cette nouvelle composition pour le lavage et le nettoyage de moules utilisés dans la fabrication de pneus ou d'autres articles en caoutchouc comprend: a) de 10 à 90 % d'une amine ou d'un mélange d'amines; b) de 2 à 20 % d'un agent tensioactif non ionique ou anionique ou d'un mélange d'agents tensioactifs, et c) de 90 à 10 % d'un solvant.
• [EN] SYNERGISTIC PERFORMANCE OF AMINE BLENDS IN SHALE CONTROL<br/>[FR] PERFORMANCE SYNERGIQUE DE MÉLANGES D'AMINES DANS LE CONTRÔLE DE SCHISTES
  申请人：HUNTSMAN PETROCHEMICAL LLC

  公开号：WO2020256863A1

  公开（公告）日：2020-12-24

  The present disclosure provides water-based well treatment fluids methods of using such fluids in treating subterranean formations to prevent swelling and/or migration of fines. The water-based well treatment fluid contains an aqueous continuous phase and a clay stabilizing agent comprising less than 20% by weight, based on the total weight of the clay stabilizing agent, of an unhindered primary amine and a second amine selected from an alkanolamine, a polyalkylene polyamine, a compound having a formula R4-(CH2)d-NH2 where R4 is a piperazino group or a morpholino group and d is an integer from 0 to 10, a compound having the formula where h is an integer from about 2 to about 7 and a mixture thereof.