1-(4-azidophenyl)urea | 1272615-20-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-azidophenyl)urea
• 英文别名: (4-Azidophenyl)urea；(4-azidophenyl)urea
• CAS: 1272615-20-9
• 化学式: C₇H₇N₅O
• 分子量: 177.165
• InChiKey: UVHJPQRPKZEJTD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  69.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (4-iodophenyl)urea 在 copper(l) iodide 、 sodium azide 、 sodium ascorbate 、 N,N'-二甲基乙二胺 作用下， 以 水 、 二甲基亚砜 为溶剂， 反应 12.0h， 以88%的产率得到1-(4-azidophenyl)urea
  参考文献：
  名称：

  Synthesis and triplex-forming ability of oligonucleotides bearing 1-substituted 1H-1,2,3-triazole nucleobases

  摘要：

  Using the copper(I)-catalyzed alkyne-azide 1,3-dipolar cycloaddition, a post-elongation modification of 1-ethynyl substituted nucleobases has been employed to construct 18 variations of oligonucleotides from a common oligonucleotide precursor. The triplex-forming ability of each oligonucleotide with dsDNA was evaluated by the UV melting experiment. It was found that triazole nucleobases generally tend to exhibit binding affinities in the following order: CG > TA > AT, GC base pairs. Among the triazole nucleobases examined, a 1-(4-ureidophenyl)triazole provided the best result with regard to affinity and selectivity for the CG base pair. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.12.049

文献信息

• Inhibitors of carbonic anhydrase IX
  申请人：Molecular Insight Pharmaceuticals, Inc.

  公开号：EP2823826A2

  公开（公告）日：2015-01-14

  Novel radiopharmaceuticals that are useful in diagnostic imaging and therapeutic treatment of disease characterized by over expression of CA-IX comprise a complex that contains a sulfonamide moiety which is capable of binding the active catalytic site of CA- IX, and a radionuclide adapted for radio-imaging and/or radiotherapy.

  可用于诊断成像和治疗以 CA- IX 过度表达为特征的疾病的新型放射性药物包括一种复合物，该复合物包含一个能够结合 CA- IX 活性催化位点的磺酰胺分子，以及一种适用于放射成像和/或放射治疗的放射性核素。
• INHIBTEURS DE L'INDOLEAMINE 2,3-DIOXYGÉNASE ET/OU DU TRYPTOPHANE DIOXYGÉNASE
  申请人：Idorsia Pharmaceuticals Ltd

  公开号：EP3740493B1

  公开（公告）日：2021-12-01
• INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE AND/OR TRYPTOPHAN 2,3-DIOXYGENASE
  申请人：Idorsia Pharmaceuticals Ltd

  公开号：EP3740493A1

  公开（公告）日：2020-11-25
• [EN] INHIBITORS OF CARBONIC ANHYDRASE IX<br/>[FR] INHIBITEURS DE L'ANHYDRASE CARBONIQUE IX
  申请人：MOLECULAR INSIGHT PHARM INC

  公开号：WO2009089383A2

  公开（公告）日：2009-07-16

  Novel radiopharmaceuticals that are useful in diagnostic imaging and therapeutic treatment of disease characterized by over expression of CA-IX comprise a complex that contains a sulfonamide moiety which Ls capable of binding the active catalytic site of CA- IX, and a radionuclide adapted for radioimaging and/or radiotherapy:
• Synthesis and triplex-forming ability of oligonucleotides bearing 1-substituted 1H-1,2,3-triazole nucleobases
  作者：Yoshiyuki Hari、Motoi Nakahara、Juanjuan Pang、Masaaki Akabane、Takeshi Kuboyama、Satoshi Obika

  DOI：10.1016/j.bmc.2010.12.049

  日期：2011.2

  Using the copper(I)-catalyzed alkyne-azide 1,3-dipolar cycloaddition, a post-elongation modification of 1-ethynyl substituted nucleobases has been employed to construct 18 variations of oligonucleotides from a common oligonucleotide precursor. The triplex-forming ability of each oligonucleotide with dsDNA was evaluated by the UV melting experiment. It was found that triazole nucleobases generally tend to exhibit binding affinities in the following order: CG > TA > AT, GC base pairs. Among the triazole nucleobases examined, a 1-(4-ureidophenyl)triazole provided the best result with regard to affinity and selectivity for the CG base pair. (C) 2011 Elsevier Ltd. All rights reserved.