benzyl diethoxyphosphine | 36103-43-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl diethoxyphosphine
• 英文别名: Benzylphosphonigsaeure-diethylester；Benzyl(diethoxy)phosphane
• CAS: 36103-43-2
• 化学式: C₁₁H₁₇O₂P
• 分子量: 212.229
• InChiKey: YOJPYCBLLSSTBL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  benzyl diethoxyphosphine 在 盐酸 作用下， 生成 Ethyl hydrogen phenylphosphonite
  参考文献：
  名称：

  Sander,M., Chemische Berichte, 1960, vol. 93, p. 1220 - 1230

  摘要：

  DOI：
• 作为产物：
  描述：

  benzyldichlorophosphane 、 乙醇 生成 benzyl diethoxyphosphine
  参考文献：
  名称：

  Gladshtein,B.M.; Shitov,L.N., Journal of general chemistry of the USSR, 1969, vol. 39, p. 1913 - 1915

  摘要：

  DOI：

文献信息

• Stable anionic, neutral and cationic complexes of gadolinium with functionalised amino-phosphinic acid macrocyclic ligands
  作者：David Parker、Kanthi Pulukkody、Timothy J. Norman、Alice Harrison、Louise Royle、Carol Walker

  DOI：10.1039/c39920001441

  日期：——

  The synthesis and stability of anionic, neutral and cationic gadolinium complexes based on tetraazaphosphinic acid ligands is compared: lipophilic anionic complexes show biliary rather than renal clearance.

  比较了基于四氮膦酸配体的阴离子、中性和阳离子钆络合物的合成和稳定性：亲油阴离子络合物显示出胆汁清除率而非肾脏清除率。
• Design and synthesis of chiral and racemic phosphonate-based haptens for the induction of aldolase catalytic antibodies
  作者：YongQi Mu、Richard A Gibbs

  DOI：10.1016/s0968-0896(97)00088-6

  日期：1997.7

  alternative phosphonate hapten 39 was prepared. The key step in the synthesis of 39 was the direct generation of an unprotected phosphonate precursor via coupling of the secondary alcohol 37 with CH3P(O)Cl2. The chiral counterpart of hapten 39 was also synthesized from alcohol 46, prepared by Corey's asymmetric reduction method. One polyclonal antibody preparation generated from 39 appeared to catalyze the

  描述了一种新的生成醛缩酶催化抗体的策略，该策略基于使用抗体催化的烯醇酯水解作为“触发”来生成反应性烯醇酸酯中间体。开发了测试该策略的模型系统，并合成了基板8。然而，靶向的双功能半抗原11和33是合成上不可及的，因此制备了替代的膦酸酯半抗原39。合成39的关键步骤是通过仲醇37与CH3P（O）Cl2的偶联直接生成未保护的膦酸酯前体。半抗原39的手性对应物也由通过Corey的不对称还原方法制备的醇46合成。一种由39生成的多克隆抗体制剂似乎可以催化仲乙酸酯49的水解，
• Synthesis and solution complexation behaviour of tetradentate diamines with hard phosphinate donors
  作者：George B. Bates、Eleanor Cole、David Parker、Ritu Kataky

  DOI：10.1039/dt9960002693

  日期：——

  Seven acyclic tetradentate compounds of varying lipophilicity incorporating two nitrogen and two alkyl or aryl phosphinate donors have been prepared and their complexation of divalent ions has been studied in aqueous solution by pH-metric, NMR and electrospray mass spectrometric methods of analysis. The hard phosphinate oxygen donor favours binding to the charge-dense Mg2+ ion but binds copper(II) only very weakly in solution. Nickel and zinc ions do form 1 : 1 complexes involving significant phosphinate ligation and this donor-atom preference leads to an inversion of the Irving–Williams stability sequence.

  我们制备了七种亲油性不同的无环四价化合物，其中包含两个氮和两个烷基或芳基膦酸盐供体，并通过 pH 值测定、核磁共振和电喷雾质谱分析方法研究了它们在水溶液中与二价离子的络合情况。硬磷酸盐氧供体有利于与电荷密集的 Mg2+ 离子结合，但在溶液中与铜(II)的结合力很弱。镍离子和锌离子确实形成了 1 : 1 的络合物，其中涉及大量的膦酸盐连接，这种供体原子偏好导致欧文-威廉姆斯稳定性序列的颠倒。
• A ratiometric and non-enzymatic luminescence assay for uric acid: differential quenching of lanthanide excited states by anti-oxidants
  作者：Robert A. Poole、Filip Kielar、Siobhan L. Richardson、Philip A. Stenson、David Parker

  DOI：10.1039/b611259e

  日期：——

  The excited states of Tb and Eu complexes of a common macrocyclic ligand are quenched preferentially by electron transfer from the urate anion, allowing the creation of a new assay to measure uric acid in biological fluids.

  一种常见大环配体的铽和铕络合物的激发态优先被尿酸阴离子的电子转移所淬灭，从而产生了一种测量生物液体中尿酸的新检测方法。
• LUMINESCENCE ASSAY USING MACROCYCLIC LANTHANIDE (III) COMPLEXES
  申请人：Parker David

  公开号：US20100055665A1

  公开（公告）日：2010-03-04

  The invention provides a method of determining the amount of an analyte having an oxidation potential, for a one electron oxidation process, of about +0.10 to about +1.20 volts at pH 7, relative to the normal hydrogen electrode at 298K, said method comprising measuring the emission intensity or emission lifetime, at two or more wavelengths, from a sample comprising said analyte and two or more different macrocyclic lanthanide (III) complexes, wherein each of said macrocyclic lanthanide (III) complexes comprises a different lanthanide ion but the same macrocyclic ligand, and using a ratio of emission intensities or emission lifetimes measured at two different wavelengths to calculate the amount of analyte in said sample.

  本发明提供了一种确定具有在pH 7下相对于298K的标准氢电极约+0.10至约+1.20伏特的一电子氧化过程的分析物数量的方法，该方法包括测量来自包含所述分析物和两种或两种以上不同的大环配位镧系(III)络合物的样品的发射强度或发射寿命，在两个或两个以上波长处，并使用在两个不同波长处测量的发射强度或发射寿命的比率来计算样品中分析物的数量，其中每个所述大环配位镧系(III)络合物包括不同的镧系离子但相同的大环配体。