1-(2-Naphthyl)-2-(1,2,4-triazole-1-yl)-1-ethanol | 119270-47-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-(2-Naphthyl)-2-(1,2,4-triazole-1-yl)-1-ethanol
• 英文别名: 1-Naphthalen-2-yl-2-(1,2,4-triazol-1-yl)ethanol
• CAS: 119270-47-2
• 化学式: C₁₄H₁₃N₃O
• mdl: MFCD16236115
• 分子量: 239.277
• InChiKey: UNSXSNIRXUBSNL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.142
• 拓扑面积：
  50.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,4-二氯氯苄 、 1-(2-Naphthyl)-2-(1,2,4-triazole-1-yl)-1-ethanol 在 sodium hydride 作用下， 生成 1-[2-[(2,4-Dichlorophenyl)methoxy]-2-(2-naphthyl)ethyl]-1,2,4-triazole
  参考文献：
  名称：

  Aromatic ethers of 1-aryl 2-(1H-azolyl)ethanol: study of antifungal activity

  摘要：

  Aromatic ethers related to antifungal azole miconazole were synthesized and tested against various strains of Candida. We found that activity is related to the nature of the aromatic ring and the position of substituents on this ring. Activity is more strongly dependent on the substituent in the 2 position of the ethyl chain than on the aromatic group linked through the oxygen. Triazoles were always less potent than the corresponding imidazole analogues.

  DOI：

  10.1016/0223-5234(96)88315-2
• 作为产物：
  描述：

  2-溴代-2-乙酰基萘 在 sodium tetrahydroborate 、 sodium 作用下， 以 甲醇 为溶剂， 反应 7.0h， 生成 1-(2-Naphthyl)-2-(1,2,4-triazole-1-yl)-1-ethanol
  参考文献：
  名称：

  咪唑环在（芳烷基）咪唑类抗惊厥活性中的意义

  摘要：

  Nafimidone [1- (2-萘基)-2- (1-咪唑基) 乙酮] 中的咪唑环被各种基团取代，以研究咪唑环在抗惊厥活性中的重要性。为此，合成了一些 2-乙酰萘衍生物及其还原产物。几种N-烷基化方法用于制备2-乙酰萘。NaBH4 用于合成它们的还原产物。这些化合物的抗惊厥活性通过抗癫痫药物开发计划的 I 期试验确定。

  DOI：

  10.1002/ardp.19883211203

文献信息

• The Significance of the Imidazole Ring in Anticonvulsant Activity of (Arylalkyl)imidazoles
  作者：Ünsal Çaliş、Sevim Dalkara、Mevlüt Ertan、Rümeysa Sunal

  DOI：10.1002/ardp.19883211203

  日期：——

  The imidazole ring in nafimidone [1‐(2‐naphthyl)‐2‐(1‐imidazolyl)ethanone] was substituted with various groups to investigate the significance of the imidazole ring in anticonvulsant activity. For this purpose, some 2‐acetylnaphthalene derivatives and their reduction products were synthesized. Several N‐alkylation methods were used to prepare 2‐acetylnaphthalenes. NaBH4 was used to synthesize their

  Nafimidone [1- (2-萘基)-2- (1-咪唑基) 乙酮] 中的咪唑环被各种基团取代，以研究咪唑环在抗惊厥活性中的重要性。为此，合成了一些 2-乙酰萘衍生物及其还原产物。几种N-烷基化方法用于制备2-乙酰萘。NaBH4 用于合成它们的还原产物。这些化合物的抗惊厥活性通过抗癫痫药物开发计划的 I 期试验确定。
• CALIS, UNSAL;DALKARA, SEVIM;ERTAN, MEVLUT;SUNAL, RUMEYSA, ARCH. PHARM., 321,(1988) N 12, C. 841-846
  作者：CALIS, UNSAL、DALKARA, SEVIM、ERTAN, MEVLUT、SUNAL, RUMEYSA

  DOI：——

  日期：——
• Aromatic ethers of 1-aryl 2-(1H-azolyl)ethanol: study of antifungal activity
  作者：Y Wahbi、R Caujolle、C Tournaire、M Payard、M.D. Linas、J.P. Seguela

  DOI：10.1016/0223-5234(96)88315-2

  日期：1995.1

  Aromatic ethers related to antifungal azole miconazole were synthesized and tested against various strains of Candida. We found that activity is related to the nature of the aromatic ring and the position of substituents on this ring. Activity is more strongly dependent on the substituent in the 2 position of the ethyl chain than on the aromatic group linked through the oxygen. Triazoles were always less potent than the corresponding imidazole analogues.