N,N,N-trimethyl-8-sulfanyloctan-1-ammonium chloride

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N,N-trimethyl-8-sulfanyloctan-1-ammonium chloride
• 英文别名: Trimethyl(8-sulfanyloctyl)azanium;chloride；trimethyl(8-sulfanyloctyl)azanium;chloride
• 化学式: C₁₁H₂₆NS*Cl
• 分子量: 239.853
• InChiKey: WJRNERGVMRNNJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.03
• 重原子数：
  14
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N,N-trimethyl-8-sulfanyloctan-1-ammonium chloride 在 碘 、 碳酸氢钠 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以90%的产率得到8,8′-disulfanediylbis(N,N,N-trimethyloctan-1-ammonium) diiodide
  参考文献：
  名称：

  通过有机硫催化程序形成 HCN 低聚物

  摘要：

  描述了一种高效、廉价且可靠的二氨基马来腈 (DAMN, 1 )合成方法，其起始于作为氰化氢 (HCN) 来源的容易获得的丙酮氰醇。众所周知，二氨基马来腈 (DAMN) 是杂环化学和药物化学中的重要中间体，也是益生元化学中生命起源假说的可能前体。通过使用两种新合成的阳离子“标记”分子作为允许灵敏检测的工具，通过电喷雾电离质谱 (ESI-MS) 研究了其通过有机硫催化形成的机制。结果，证实了从有机二硫化物开始的硫氰酸盐介导合成 HCN 四聚体 DAMN 的拟议机制。

  DOI：

  10.1021/acs.joc.1c01023
• 作为产物：
  描述：

  1,8-二溴辛烷 在 盐酸 作用下， 以 乙醇 、 水 、 丙酮 、 乙腈 为溶剂， 反应 3.0h， 生成 N,N,N-trimethyl-8-sulfanyloctan-1-ammonium chloride
  参考文献：
  名称：

  Assessment of the morphology of mixed SAMs on Au nanoparticles using a fluorescent probe

  摘要：

  通过使用荧光探针进行分光光度滴定，可以直接确定混合 SAM 中硫醇的分布情况。饱和浓度与分子分数的函数关系图提供了参与结合的头基数的信息。

  DOI：

  10.1039/c0cc02260h

文献信息

• Polyvinyl acetal and its use
  申请人：Kuraray Co., Ltd.

  公开号：EP1384730A1

  公开（公告）日：2004-01-28

  The invention provides a polyvinyl acetal having a degree of acetalization of from 45 to 80 mol%, which is obtained through acetalization of a polyvinyl alcohol having a degree of polymerization of from 30 to 1000 and a degree of hydrolysis of from 80.0 to 99.99 mol% and having a specific amount of an ionic group bonded to the terminal thereof via a sulfido bond. The polyvinyl acetal of the invention is useful for binders for ceramic forming and for binders for ink or paint.

  本发明提供了一种聚乙烯醇缩醛，其缩醛度为 45 至 80 摩尔%，它是通过缩醛聚乙烯醇而得，聚乙烯醇的聚合度为 30 至 1000，水解度为 80.0 至 99.99 摩尔%，并有一定量的离子基团通过亚硫酰基键与其末端结合。本发明的聚乙烯醇缩醛可用于陶瓷成型粘合剂和油墨或涂料粘合剂。
• Tunable Reactivation of Nanoparticle-Inhibited β-Galactosidase by Glutathione at Intracellular Concentrations
  作者：Ayush Verma、Joseph M. Simard、Joseph W. E. Worrall、Vincent M. Rotello

  DOI：10.1021/ja046572r

  日期：2004.11.1

  Positively charged trimethylammonium-functionalized mixed monolayer protected clusters (MMPCs) of different chain lengths (C-8 and C-11) have been used to bind beta-galactosidase through complementary electrostatic interactions, resulting in complete enzyme inhibition. This inhibition can be reversed in vitro by intracellular concentrations of glutathione (GSH), the main thiol component of the cell. The restoration of activity depends on the chain length of the monolayer. The activity of enzyme bound to particles with C-8 monolayer was completely restored by intracellular concentrations (1 - 10 mM) of GSH; however, little or no release was observed at extracellular GSH concentrations. In contrast, no restoration was observed for enzyme bound to the C-11 particles at any of the concentrations studied. Taken together, these studies demonstrate that the GSH-mediated release of enzymes bound to MMPCs can be tuned through the structure of the monolayer, a significant tool for protein and drug delivery applications.
• US7056977B2
  申请人：——

  公开号：US7056977B2

  公开（公告）日：2006-06-06
• Programmed Formation of HCN Oligomers through Organosulfur Catalysis
  作者：Caroline Grundke、Caleb Kong、Christopher J. Kampf、B. Frank Gupton、D. Tyler McQuade、Till Opatz

  DOI：10.1021/acs.joc.1c01023

  日期：2021.8.6

  diaminomaleonitrile (DAMN, 1) is described starting from readily available acetone cyanohydrin as the source of hydrogen cyanide (HCN). Diaminomaleonitrile (DAMN) is known to be an important intermediate in heterocyclic and medicinal chemistry as well as being a possible precursor for the origin of life’s hypothesis within prebiotic chemistry. The mechanism of its formation through organosulfur catalysis has been investigated

  描述了一种高效、廉价且可靠的二氨基马来腈 (DAMN, 1 )合成方法，其起始于作为氰化氢 (HCN) 来源的容易获得的丙酮氰醇。众所周知，二氨基马来腈 (DAMN) 是杂环化学和药物化学中的重要中间体，也是益生元化学中生命起源假说的可能前体。通过使用两种新合成的阳离子“标记”分子作为允许灵敏检测的工具，通过电喷雾电离质谱 (ESI-MS) 研究了其通过有机硫催化形成的机制。结果，证实了从有机二硫化物开始的硫氰酸盐介导合成 HCN 四聚体 DAMN 的拟议机制。
• Assessment of the morphology of mixed SAMs on Au nanoparticles using a fluorescent probe
  作者：Renato Bonomi、Alessandro Cazzolaro、Leonard J. Prins

  DOI：10.1039/c0cc02260h

  日期：——

  The distribution of thiols in mixed SAMs can be determined in a straightforward manner from spectrophotometric titrations using a fluorescent probe. A plot of saturation concentration as a function of mole fraction provides information on the number of headgroups involved in binding.

  通过使用荧光探针进行分光光度滴定，可以直接确定混合 SAM 中硫醇的分布情况。饱和浓度与分子分数的函数关系图提供了参与结合的头基数的信息。