ethyl 3-(p-methylphenyl)-4-oxo-3,4-dihydroquinazoline-2-carboxylate | 87967-92-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: ethyl 3-(p-methylphenyl)-4-oxo-3,4-dihydroquinazoline-2-carboxylate
• 英文别名: Ethyl 3-(4-methylphenyl)-4-oxo-3,4-dihydro-2-quinazolinecarboxylate；ethyl 3-(4-methylphenyl)-4-oxoquinazoline-2-carboxylate
• CAS: 87967-92-8
• 化学式: C₁₈H₁₆N₂O₃
• 分子量: 308.337
• InChiKey: KDLWRVXQNWMWCI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  59
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  溴苯 、 ethyl 3-(p-methylphenyl)-4-oxo-3,4-dihydroquinazoline-2-carboxylate 在 magnesium 作用下， 以 四氢呋喃 为溶剂， 以70%的产率得到2-[hydroxy(diphenyl)methyl]-3-(p-methylphenyl)-4-oxo-3,4-dihydroquinazoline
  参考文献：
  名称：

  Synthesis of 3-aryl-2-[hydroxy(diaryl)methyl]-4-oxo-3,4-dihydroquinazolines

  摘要：

  By heating arylamides of N-ethoxalylanthranilic acid in the acetic acid mediun in the presence of triethylamine the corresponding ethyl 3-aryl-4-oxo-3,4-dihydroquinazoline-2-carboxylates were obtained. The latter in the conditions of the Grignard reaction formed 3-aryl-2-[hydroxy-(diaryl)methyl]-4-oxo-3,4-dihydroquinazolines.

  DOI：

  10.1134/s107042801011014x
• 作为产物：
  描述：

  2-氨基-N-对甲苯苯甲酰胺 在 溶剂黄146 、 三乙胺 作用下， 反应 1.17h， 生成 ethyl 3-(p-methylphenyl)-4-oxo-3,4-dihydroquinazoline-2-carboxylate
  参考文献：
  名称：

  Synthesis of 3-aryl-2-[hydroxy(diaryl)methyl]-4-oxo-3,4-dihydroquinazolines

  摘要：

  By heating arylamides of N-ethoxalylanthranilic acid in the acetic acid mediun in the presence of triethylamine the corresponding ethyl 3-aryl-4-oxo-3,4-dihydroquinazoline-2-carboxylates were obtained. The latter in the conditions of the Grignard reaction formed 3-aryl-2-[hydroxy-(diaryl)methyl]-4-oxo-3,4-dihydroquinazolines.

  DOI：

  10.1134/s107042801011014x

文献信息

• BOTROS, S.;OSMAN, A. N., EGYPT. J. SCI., 1982, 25, N 6, 579-582
  作者：BOTROS, S.、OSMAN, A. N.

  DOI：——

  日期：——
• Synthesis of 3-aryl-2-[hydroxy(diaryl)methyl]-4-oxo-3,4-dihydroquinazolines
  作者：L. A. Shemchuk、V. P. Chernykh、D. V. Levashov、K. M. Sytnik、L. M. Shemchuk

  DOI：10.1134/s107042801011014x

  日期：2010.11

  By heating arylamides of N-ethoxalylanthranilic acid in the acetic acid mediun in the presence of triethylamine the corresponding ethyl 3-aryl-4-oxo-3,4-dihydroquinazoline-2-carboxylates were obtained. The latter in the conditions of the Grignard reaction formed 3-aryl-2-[hydroxy-(diaryl)methyl]-4-oxo-3,4-dihydroquinazolines.