6-hydroxy-7-methoxychroman-2-carboxylic acid phenyl amide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 6-hydroxy-7-methoxychroman-2-carboxylic acid phenyl amide
• 英文别名: 6-hydroxy-7-methoxychroman-2-carboxylic acid phenylamide；KL-1156；6-hydroxy-7-methoxy-N-phenyl-3,4-dihydro-2H-chromene-2-carboxamide
• 化学式: C₁₇H₁₇NO₄
• 分子量: 299.326
• InChiKey: JXCMRGWJFGLXJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  67.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-甲氧基对苯二酚 在 palladium on activated charcoal 三氯化铝 、 氢气 、 sodium acetate 、 1-羟基苯并三唑 、 溶剂黄146 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 为溶剂， 反应 12.0h， 生成 6-hydroxy-7-methoxychroman-2-carboxylic acid phenyl amide
  参考文献：
  名称：

  Synthesis and evaluation of 6-hydroxy-7-methoxy-4-chromanone- and chroman-2-carboxamides as antioxidants

  摘要：

  A series of 6-hydroxy-7-methoxy-4-chromanone- (2a-e) and chroman-2-carboxamides (3a-e) were synthesized and their antioxidant activities were evaluated. While compounds 2a-e were less active, compounds 3a-e exhibited more potent inhibition of lipid peroxidation initiated by Fe2+ and ascorbic acid in rat brain homogenates. Among them, N-arylsubstituted-chroman-2-carboxamides (3d and 3e) exhibited 25-40 times more potent inhibition than trolox (1). The DPPH radical scavenging activity of compound 3d was comparable to that of trolox. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.03.118

文献信息

• Clonidine to treat pain locally
  申请人：Medtronic, Inc.

  公开号：EP2363122A1

  公开（公告）日：2011-09-07

  The present invention is directed to systems and methods for contributing to the local treatment of pain. More specifically, the present invention is directed to the use of one or more NFKB inhibiting compounds, particularly clonidine, in the manufacture of a medicament for the treatment of pain wherein said medicament is for local administration to a patient in need thereof.

  本发明涉及有助于局部治疗疼痛的系统和方法。更具体地说，本发明涉及将一种或多种 NFKB 抑制化合物，特别是氯硝柳胺，用于制造治疗疼痛的药物，其中所述药物用于对有需要的患者进行局部给药。
• Systems and Methods to Treat Pain Locally
  申请人：Burright N. Eric

  公开号：US20060253100A1

  公开（公告）日：2006-11-09

  Disclosed herein are systems and methods for contributing to the local treatment of pain. More specifically, the disclosed systems and methods contribute to the local treatment pain by inhibiting the NFκB family of transcription factors.

  本文公开了有助于局部治疗疼痛的系统和方法。更具体地说，所公开的系统和方法通过抑制转录因子 NFκB 家族来促进疼痛的局部治疗。
• NFKAPPAB INHIBITORS TO TREAT PAIN LOCALLY
  申请人：MEDTRONIC, INC.

  公开号：EP2043625A1

  公开（公告）日：2009-04-08
• COMPOSITIONS AND METHODS FOR MODULATING IMMUNE RESPONSES
  申请人：THE UNIVERSITY OF QUEENSLAND

  公开号：EP2077821B1

  公开（公告）日：2019-08-14
• Implant pellet comprising clonidine to treat pain locally
  申请人：Medtronic, Inc.

  公开号：EP2363122B1

  公开（公告）日：2014-06-11