1-Diprenylamino-2-hydroxyaethan | 43219-11-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-Diprenylamino-2-hydroxyaethan
• 英文别名: 2-[Bis(3-methylbut-2-enyl)amino]ethanol
• CAS: 43219-11-0
• 化学式: C₁₂H₂₃NO
• 分子量: 197.321
• InChiKey: RULPKNQEEMVTLP-UHFFFAOYSA-N

物化性质

• 沸点：
  285.6±20.0 °C(Predicted)
• 密度：
  0.904±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-Diprenylamino-2-hydroxyaethan 在 吡啶 、 氯化亚砜 作用下， 以 Petroleum ether 为溶剂， 生成 alpha,alpha-二[2-[二(3-甲基-2-丁烯基)氨基]乙基]-1-萘乙腈
  参考文献：
  名称：

  Analgetic-antiinflammatory activity of prenyl derivatives of basic naphthylalkylnitriles and naphthylalkylamides chemically related to naphthypramide

  摘要：

  DOI：

  10.1021/jm00264a038
• 作为产物：
  描述：

  C.I.酸性橙108 、 1-溴-3-甲基-2-丁烯 以 乙醚 为溶剂， 生成 1-Diprenylamino-2-hydroxyaethan
  参考文献：
  名称：

  Analgetic-antiinflammatory activity of prenyl derivatives of basic naphthylalkylnitriles and naphthylalkylamides chemically related to naphthypramide

  摘要：

  DOI：

  10.1021/jm00264a038

文献信息

• Methods for treatment of dermatological conditions
  申请人：Wang Bing

  公开号：US20050032751A1

  公开（公告）日：2005-02-10

  A method of reducing the appearance of skin conditions associated with loss of skin tightness, skin firmness, or dark circles under the eyes with topical compositions comprising compounds of any of the Formulae I or Ia as described herein, is disclosed.

  本文揭示了一种通过含有本文所述的任何Formulae I或Ia化合物的局部组合物来减少与皮肤松弛、皮肤紧致度或眼部黑眼圈相关的皮肤状况的方法。
• METHODS FOR TREATMENT OF DERMATOLOGICAL CONDITIONS
  申请人：Wang Bing

  公开号：US20100202989A1

  公开（公告）日：2010-08-12

  A method of reducing the appearance of skin conditions associated with loss of skin tightness, skin firmness, or dark circles under the eyes with topical compositions comprising compounds of any of the Formulae I or Ia as described herein, is disclosed.

  本发明揭示了一种使用含有任何公式I或Ia中所述化合物的局部组合物来减少与皮肤紧致度丧失、皮肤紧致度降低或眼部黑眼圈相关的皮肤状况的外观的方法。
• Applications of Stevens [1,2]-Shifts of Cyclic Ammonium Ylides. A Route to Morpholin-2-ones
  作者：F. G. West、B. N. Naidu

  DOI：10.1021/jo00099a041

  日期：1994.10

  2-(N,N-Dialkylamino)ethyl diazoacetoacetates 2 were prepared in two steps from readily available ethanolamines 1. When heated in the presence of catalytic Cu, the substrates cleanly formed morpholinones 3, presumably via the intermediacy of copper carbenoids and cyclic ammonium ylides. In most cases involving benzylic or allylic migrating groups, ylide [1,2]-shift occurred in good yield (55-80%). In the case of benzhydryl containing substrate 2g, only dimer 4 was isolated. Simple alkyl groups failed to undergo the rearrangement, with the exception of tert-butyl case 2i, which furnished morpholinone 3i in low yield. Substituted allylic case 2l gave only [1,2]-shift product 3l, with no evidence for competing [2,3]-shift to give 3l'. Diazoacetates 2n-p also underwent conversion to morpholinones 3n-p in 19-64% yield with Cu(acac)(2) catalysis.
• Minoli; Omodei-Salè; Boniardi, Farmaco, Edizione Scientifica, 1973, vol. 28, # 7, p. 539 - 544
  作者：Minoli、Omodei-Salè、Boniardi

  DOI：——

  日期：——
• West F. G., Naidu B. N., J. Org. Chem, 59 (1994) N 20, S 6051-6056
  作者：West F. G., Naidu B. N.

  DOI：——

  日期：——