2-hydroxy-4,5-dimethyl-isophthalic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-hydroxy-4,5-dimethyl-isophthalic acid
• 英文别名: 2-Hydroxy-4,5-dimethyl-isophthalsaeure；2-Hydroxy-4,5-dimethylbenzene-1,3-dicarboxylic acid；2-hydroxy-4,5-dimethylbenzene-1,3-dicarboxylic acid
• 化学式: C₁₀H₁₀O₅
• 分子量: 210.186
• InChiKey: GDKUFEYPOLYLBY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  94.8
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-hydroxy-4,5-dimethyl-isophthalic acid 在 喹啉 作用下， 生成 3,4-二甲基苯酚
  参考文献：
  名称：

  Zur Kenntnis der Phenol-合成ausβ-二羰基-Verbindungen和Ketonen

  摘要：

  贝因斯菲伦的本能论与β-二羧基-Verbindungen和Ketenen mit zweiα-ständigenMethylen-Gruppen的关系，等等。

  DOI：

  10.1002/hlca.19510340128
• 作为产物：
  描述：

  1,3-丙酮二羧酸二乙酯 、 alkaline earth salt of/the/ methylsulfuric acid 在 乙醇 作用下， 生成 2-hydroxy-4,5-dimethyl-isophthalic acid
  参考文献：
  名称：

  Zur Kenntnis der Phenol-合成ausβ-二羰基-Verbindungen和Ketonen

  摘要：

  贝因斯菲伦的本能论与β-二羧基-Verbindungen和Ketenen mit zweiα-ständigenMethylen-Gruppen的关系，等等。

  DOI：

  10.1002/hlca.19510340128

文献信息

• Labile linkage for compound delivery to a cell
  申请人：Rozema B. David

  公开号：US20050054604A1

  公开（公告）日：2005-03-10

  Described are ortho carboxy phenol derived acetals and compositions containing ortho carboxy phenol derived acetals which are useful for delivering biologically active compounds to cells. The acetals can be used to reversibly link up to three different molecules and have rapid hydrolysis kinetics in conditions which are present in a cell as well as in vivo. Cleavage of the acetal enhances delivery of the biologically active compound.

  描述了由邻羟基苯甲醛衍生的缩醛和含有这种缩醛的组合物，这些缩醛对于将生物活性化合物传递到细胞中是有用的。这些缩醛可以用于可逆地连接最多三种不同的分子，并且在细胞内以及体内存在的条件下具有快速的水解动力学。缩醛的裂解增强了生物活性化合物的传递。
• Multiply-branched aliphatic-aromatic polyether esters and their preparation
  申请人：EASTMAN KODAK COMPANY

  公开号：EP0583609A1

  公开（公告）日：1994-02-23

  A multiply-branched aliphatic-aromatic polyester and a method for producing that polymer. The method comprises condensing Z¹ and Z² groups of a branching reactant having the general formula Z¹-Ar-(Z²)j. In this formula, j is 2 or 3 and Ar is an aryl or heteroaryl group having from 1 to 3, solitary or linked or fused, substituted or unsubstituted, five or six membered rings. One of Z¹ and Z² is a group having the general formula in which R¹ is selected from the group consisting of hydroxy, chloro, bromo, monovalent alkoxide having from 1 to 6 carbons, and -O-(CH₂)d-OH, wherein d is an integer from 1 to 3; and the other is a group having the general formula in which R² is a divalent alkyl group having from 1 to 6 carbon atoms, and g is an integer from 0 to 100.

  一种多支链脂肪族-芳香族聚酯和一种生产该聚合物的方法。该方法包括缩合通式为 Z¹-Ar-(Z²)j 的分支反应物的 Z¹ 和 Z² 基团。在该式中，j 为 2 或 3，Ar 为芳基或杂芳基，具有 1 至 3 个单环或相连或融合、取代或未取代的五或六成员环。Z¹ 和 Z² 中的一个是通式为 其中 R¹ 选自羟基、氯、溴、具有 1 至 6 个碳原子的一价烷氧基和 -O-(CH₂)d-OH（其中 d 为 1 至 3 的整数）组成的组；另一个是具有通式的基团。 其中 R² 是具有 1 至 6 个碳原子的二价烷基，g 是 0 至 100 的整数。
• Novel amphiphilic polymeric materials
  申请人：——

  公开号：US20020099164A1

  公开（公告）日：2002-07-25

  The invention is based in part on the discovery of polymers that can complex with certain types of therapeutic drugs and transport those drugs across cell membranes in cell cultures with demonstrable therapeutic activity. The polymers are designed to overcome some of the known problems of liposomes as drug carriers. The polymers can be used in the development of physiologically stable, non-leaking, non-immunogenic, efficacious and safe targetable drug delivery systems (e.g., for delivery of anti-HIV or anticancer drugs).

  本发明的部分依据是发现了一种聚合物，它能与某些类型的治疗药物复合，并在细胞培养中跨细胞膜转运这些药物，具有明显的治疗活性。这种聚合物旨在克服脂质体作为药物载体的一些已知问题。这种聚合物可用于开发生理稳定、无渗漏、无免疫原性、高效和安全的靶向药物输送系统（例如，用于输送抗艾滋病毒或抗癌药物）。
• Labile Linkage for Compound Delivery to a Cell
  申请人：Rozema David B.

  公开号：US20080132689A1

  公开（公告）日：2008-06-05

  Described are ortho carboxy phenol derived acetals and compositions containing ortho carboxy phenol derived acetals which are useful for delivering biologically active compounds to cells. The acetals can be used to reversibly link up to three different molecules and have rapid hydrolysis kinetics in conditions which are present in a cell as well as in vivo. Cleavage of the acetal enhances delivery of the biologically active compound.
• US5225522A
  申请人：——

  公开号：US5225522A

  公开（公告）日：1993-07-06