mono(2-hydroxyethyl) phenylphosphonate | 7671-08-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: mono(2-hydroxyethyl) phenylphosphonate
• 英文别名: 2-Hydroxyethoxy(phenyl)phosphinic acid；2-hydroxyethoxy(phenyl)phosphinic acid
• CAS: 7671-08-1
• 化学式: C₈H₁₁O₄P
• 分子量: 202.147
• InChiKey: MTEIJTHTDOJJFF-UHFFFAOYSA-N

物化性质

• 沸点：
  368.8±44.0 °C(Predicted)
• 密度：
  1.34±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  phenylmagnesium chloride 、 2-氯-2-氧-1,3,2-二氧磷杂环戊烷 生成 mono(2-hydroxyethyl) phenylphosphonate
  参考文献：
  名称：

  环状有机磷化合物-IV：用格氏试剂裂解1,3,2-二氧杂膦环和1,3,2-二氧杂膦环

  摘要：

  基于1,3,2-二氧杂膦环烷和1,3,2-二氧杂膦环烷环系统的环状磷酰氯和苯基膦酸酯在用苯基卤化镁处理时会发生环裂解，从而生成ω-羟烷基二苯基次膦酸，这是该反应的主要产物。讨论了这些反应的可能机制。

  DOI：

  10.1016/s0040-4020(01)83312-3

文献信息

• Method and compositions for identifying anti-HIV therapeutic compounds
  申请人：Arimilli N. Murty

  公开号：US20050239054A1

  公开（公告）日：2005-10-27

  Methods are provided for identifying anti-HIV therapeutic compounds substituted with carboxyl ester or phosphonate ester groups. Libraries of such compounds are screened optionally using the novel enzyme GS-7340 Ester Hydrolase. Compositions and methods relating to GS-7340 Ester Hydrolase also are provided.

  提供了一种识别含有羧酸酯或磷酸酯基团取代的抗HIV治疗化合物的方法。可以选择使用新型酶GS-7340酯水解酶对这类化合物库进行筛选。还提供了与GS-7340酯水解酶相关的组合物和方法。
• Cellular accumulation of phosphonate analogs of HIV protease inhibitor compounds
  申请人：Arimilli N. Murty

  公开号：US20050209197A1

  公开（公告）日：2005-09-22

  Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.

  本发明揭示了具有抗HIV蛋白酶活性的膦酸酯取代化合物，可用作治疗剂和其他工业用途。该组合物抑制HIV蛋白酶活性和/或在治疗艾滋病和其他抗病毒感染方面有用，以及在检测HIV蛋白酶的测定中有用。
• Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds
  申请人：Arimilli N. Murty

  公开号：US20070010489A1

  公开（公告）日：2007-01-11

  Phosphonate substituted compounds with HIV protease inhibitory properties having use as therapeutics and for other industrial purposes are disclosed. The compositions inhibit 5 HIV protease activity and/or are useful therapeutically for the treatment of AIDS and other antiviral infections, as well as in assays for the detection of HIV protease.

  本发明揭示了具有HIV蛋白酶抑制剂性质的膦酸酯取代化合物，其具有作为治疗剂和其他工业用途的用途。该组合物抑制5型HIV蛋白酶活性和/或在治疗艾滋病和其他抗病毒感染方面具有治疗作用，以及在检测HIV蛋白酶方面的检测中有用。
• FLAME RETARDANT POLYESTER
  申请人：KANEBO, LTD.

  公开号：EP0731124A1

  公开（公告）日：1996-09-11

  A flame-retardant polyester comprising a thermoplastic polyester and, introduced thereinto, at least one flame-retardant component comprising phosphorus-containing dicarboxylic acid or diol units selected from among three components represented by the following general formula: in a phosphorus atom content of 0.2-3.0 wt.% based on the total weight, and mouldings thereof, such as fiber, film and resin moldings, wherein R represents alkyl, aryl or aralkyl; and X represents a group selected from among -R1COO-, OR2O-(-OC-A-COOR2O-)-a and -(-OR2-)-bO-A-O-(-R2O-)-c, wherein R1 represents alkylene bonded to the phosphorus atom, R2 represents C2-C4 alkylene, A represents a divalent aromatic residue, a=1-10, b=0-5, and c=0-5. The flame-retardant component has excellent heat resistance, does not sublime in the step of introducing the same into a high-temperaure polyester reaction system or during the molding of the polyester, is excellent in durability under repeated washing, light-fastness and whiteness, and does not deteriorate the properties inherent in thermoplastic polyester.

  一种阻燃聚酯，由热塑性聚酯和至少一种阻燃组分组成，阻燃组分包含从以下通式所代表的三种组分中选出的含磷二羧酸或二醇单元： 在磷原子含量为 0.2-3.0 wt.其中 R 代表烷基、芳基或芳烷基；和 X 代表选自-R1COO-、OR2O-(-OC-A-COOR2O-)-a 和-(-OR2-)-bO-A-O-(-R2O-)-c 的基团，其中 R1 代表与磷原子键合的亚烷基，R2 代表 C2-C4 亚烷基，A 代表二价芳香族残基，a=1-10，b=0-5 和 c=0-5。该阻燃剂成分具有优异的耐热性，在将其引入高温聚酯反应体系的步骤中或在聚酯成型过程中不会升华，在反复洗涤、耐光性和白度方面具有优异的耐久性，并且不会降低热塑性聚酯的固有特性。
• ADHESIVE FOR TEETH-STRAIGHTENING MEMBERS
  申请人：Nihon University

  公开号：EP2149360A1

  公开（公告）日：2010-02-03

  The present invention discloses an adhesive for orthodontic attachments, which contains (A) a polymerizable monomer, (B) a polymerization initiator and (C) a fluorescent dye and, when cured, exhibits a fluorescence spectrum having a peak at 400 to 800 nm. As the polymerization initiator (B), there is preferably used a compound which generates a radical through the transfer of hydrogen between two components, or a compound which generates a radical species through intramolecular cleavage. As the fluorescent dye (C), a coumarin type dye is used preferably.

  本发明公开了一种用于正畸附件的粘合剂，它含有 (A) 一种可聚合单体，(B) 一种聚合引发剂和 (C) 一种荧光染料，当固化时，其荧光光谱的峰值在 400 至 800 纳米之间。作为聚合引发剂（B），最好使用通过两个组分之间的氢转移产生自由基的化合物，或通过分子内裂解产生自由基的化合物。作为荧光染料（C），最好使用香豆素类染料。