1,3-dimethyl-2-(p-tolyloxy)benzene | 118095-15-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,3-dimethyl-2-(p-tolyloxy)benzene
• 英文别名: 1,3-Dimethyl-2-(4-methylphenoxy)benzene
• CAS: 118095-15-1
• 化学式: C₁₅H₁₆O
• 分子量: 212.291
• InChiKey: QMAONANBRKCOGM-UHFFFAOYSA-N

物化性质

• 沸点：
  290.9±9.0 °C(Predicted)
• 密度：
  1.016±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2,6-二甲基苯酚 、 4-碘甲苯 在 potassium hydroxide 作用下， 反应 0.5h， 以71%的产率得到1,3-dimethyl-2-(p-tolyloxy)benzene
  参考文献：
  名称：

  负载在半胱氨酸官能化MNP上的钯纳米颗粒作为绿色介质中快速O-和N-芳基化反应的可靠可循环催化剂

  摘要：

  通过将Pd固定在半胱氨酸官能化的磁性纳米粒子的表面上，制得了具有磁性的可循环利用的纳米催化剂（[受电子邮件保护]）。使用多种技术（例如FT-IR，XRD，TEM，SEM，EDX，VSM和ICP）对这种纳米催化剂进行了表征。研究了催化剂（[受电子邮件保护]）在O-芳基化和N-芳基化反应中的应用。在绿色介质和温和的反应条件下，发现这种无膦配合物是高效的多相催化剂。另外，十个循环后，它具有出色的可回收性，而不会明显失活。

  DOI：

  10.1016/j.jorganchem.2019.05.011

文献信息

• Copper Mediated Formation of Carbon-Heteroatom Bonds Using Organoboron Reagents and Ultrasound
  作者：George W. Kabalka、Bryan J. Musolino

  DOI：10.3987/com-14-s(k)18

  日期：——

  This report summarizes research efforts focused on copper acetate mediated reactions to form new carbon-heteroatom bonds using organoboron reagents under ultrasound irradiation. The method involves the application of ultrasound irradiation to the Chan-Evans-Lam reaction to achieve O-arylation of phenols, N-arylation of anilines and indoles, and S-arylation of thiols. Ultrasound irradiation was found to decrease reaction times from 72 hours to 4 hours while improving the product yields an average of 20%(1) Representative C-O, C-N, and C-S coupling reactions were successfully scaled-up from the milligram to gram levels while maintaining good product yields offering potential applications in industrial processes.
• Facile synthesis of 9-azajulolidine and its application to post-Ullmann reactions
  作者：Ken-Tsung Wong、Sung-Yu Ku、Feng-Wen Yen

  DOI：10.1016/j.tetlet.2007.05.094

  日期：2007.7

  This Letter describes the efficient synthesis of 9-azajulolidine from readily available reagents and its utilization as an effective electron-rich ligand for post-Ullmann-type reactions, that is, for C(aryl)-heteroatom (N, O, S) bond formation reactions, with dramatically enhanced reaction rates. (C) 2007 Elsevier Ltd. All rights reserved.
• Copper-catalyzed Ullmann coupling under ligand- and additive- free conditions. Part 1: O-Arylation of phenols with aryl halides
  作者：Joyce Wei Wei Chang、Sheena Chee、Shiya Mak、Pongchart Buranaprasertsuk、Warinthorn Chavasiri、Philip Wai Hong Chan

  DOI：10.1016/j.tetlet.2008.01.062

  日期：2008.3

  O-Arylation of a wide variety of substituted phenols and aliphatic alcohols with aryl halides catalyzed by copper iodide under mild ligand and additive free conditions ((BU4NBr)-B-n, DMF, K3PO4, reflux, 22 h) is accomplished in good to excellent product yields (up to 95%). (c) 2008 Elsevier Ltd. All rights reserved.
• Palladium nanoparticles supported on cysteine-functionalized MNPs as robust recyclable catalysts for fast O- and N-arylation reactions in green media
  作者：Abdol R. Hajipour、Zahra Khorsandi、S. Fatemeh Mohammadi Metkazini

  DOI：10.1016/j.jorganchem.2019.05.011

  日期：2019.10

  cysteine-functionalized magnetic nanoparticles ([email protected]). This nanocatalyst was characterized using various techniques such as FT-IR, XRD, TEM, SEM, EDX, VSM, and ICP. The application of catalyst ([email protected]) was investigated for O-arylation and N-arylation reactions. This phosphine-free complex was found as highly efficient heterogeneous catalyst in green media and mild reaction conditions. In addition

  通过将Pd固定在半胱氨酸官能化的磁性纳米粒子的表面上，制得了具有磁性的可循环利用的纳米催化剂（[受电子邮件保护]）。使用多种技术（例如FT-IR，XRD，TEM，SEM，EDX，VSM和ICP）对这种纳米催化剂进行了表征。研究了催化剂（[受电子邮件保护]）在O-芳基化和N-芳基化反应中的应用。在绿色介质和温和的反应条件下，发现这种无膦配合物是高效的多相催化剂。另外，十个循环后，它具有出色的可回收性，而不会明显失活。