1-膦酰基辛基膦酸 | 2530-50-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机膦酸及其衍生物
• 中文名称: 1-膦酰基辛基膦酸
• 英文名称: P,P'-(octane-1,1-diyl)-bis-phosphonic acid
• 英文别名: octane-1,1-diphosphonic acid；Phosphonic acid, octylidenebis-；1-phosphonooctylphosphonic acid
• CAS: 2530-50-9
• 化学式: C₈H₂₀O₆P₂
• 分子量: 274.191
• InChiKey: ROKLPPRTPHAGFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  115
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1-氯己烷 在 盐酸 、 magnesium 作用下， 以 四氢呋喃 为溶剂， 反应 13.0h， 生成 1-膦酰基辛基膦酸
  参考文献：
  名称：

  Bisphosphonates derived from fatty acids are potent inhibitors of Trypanosoma cruzi farnesyl pyrophosphate synthase

  摘要：

  Studies on the mode of action of a series of bisphosphonates derived from fatty acids, which had previously proved to be potent inhibitors against Trypanosoma cruzi proliferation in in vitro assays, have been performed. Some of these drugs proved to be potent inhibitors against the intracellular form of the parasite, exhibiting IC50 values at the low micromolar level. As bisphosphonates are FDA clinically approved for treatment of bone resorption disorders, their potential innocuousness makes them good candidates to control tropical diseases. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00663-2

文献信息

• Potent and Selective Inhibition of Acid Sphingomyelinase by Bisphosphonates
  作者：Anke G. Roth、Daniela Drescher、Yang Yang、Susanne Redmer、Stefan Uhlig、Christoph Arenz

  DOI：10.1002/anie.200903288

  日期：2009.9.28

  mending bones: A simple geminal aminobisphosphonate (see picture) is the most potent selective inhibitor of the acid sphingomyelinase known to date. It can be synthesized in a one‐step procedure and inhibits cell death in vitro. Since the acid sphingomyelinase is a putative drug target for inflammatory lung diseases, bisphosphonates may find application in the treatment of pulmonary diseases.

  不仅仅是修补骨头：简单的双氨基双膦酸酯（参见图片）是迄今为止已知的最有效的酸性鞘磷脂酶抑制剂。它可以一步一步合成，并在体外抑制细胞死亡。由于酸性鞘磷脂酶是炎性肺部疾病的推定药物靶标，因此双膦酸盐可用于治疗肺部疾病。
• Bisphosphonates as inhibitors of acid sphingomyelinase
  申请人：Humboldt Universität zu Berlin

  公开号：EP2289900A1

  公开（公告）日：2011-03-02

  The present invention refers to bisphosphonate and phosphonate/phosphate compounds of Formulae I and II and its use as inhibitors of aSMase enzyme activity.

  本发明涉及Formulae I和II的双膦酸盐和膦酸盐/磷酸盐化合物，以及其作为aSMase酶活性抑制剂的用途。
• Low phosphate detergent composition for fabric washing
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0001310A1

  公开（公告）日：1979-04-04

  A detergent composition having a phosphorous content of no more than 6 % and a solution pH of less than 10 contains an organic detergent, a carboxylate builder having a pK, of less than 9 and a small amount of a polyphosphonic acid. Typical compositions utilise a citrate or succinate builder together with ethylene diaminetetramethylene phosphonate. The compositions are particularly effective in the area of bleachable stain removal.

  一种磷含量不超过 6%、溶液 pH 值小于 10 的洗涤剂组合物含有一种有机洗涤剂、一种 pK 值小于 9 的羧酸盐促进剂和少量的多膦酸。 典型的组合物使用柠檬酸盐或琥珀酸盐促进剂以及乙烯二胺四亚甲基膦酸盐。 这种组合物在漂白去污方面特别有效。
• Detergent compositions having improved bleaching effect
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0001853A1

  公开（公告）日：1979-05-16

  A neutral to mildly alkaline detergent composition based on a particulate crystalline aluminosilicate builder and containing a low level of a polyphosphonic acid, especieily ethylene diamine tetramethylene phosphonic acid, or salt thereof. The composition exhibits excellent all-round detergency, especially for oxidizable-type stains, even in the. absance of per-bleach components.

  一种中性至弱碱性洗涤剂组合物，以微粒结晶铝硅酸盐筑底剂为基础，并含有少量的多膦酸，特别是乙二胺四亚甲基膦酸或其盐。 该组合物具有出色的全面去污能力，特别是对于可氧化型污渍，即使在不含过漂白剂成分的情况下也是如此。
• Stabilized radiographic scanning agents and method for preparing them
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0004684A2

  公开（公告）日：1979-10-17

  Stable compositions, useful as technetium-99m-based scintigraphic agents, comprise gentisic acid or a pharmaceutically-acceptable salt or ester thereof in combination with a pertechnetate reducing agent or dissolved in pertechnetate-99m (ssmTcO4) solution. The compositions are especially useful in combination with a phosphate or phosphonate material which carries the radionuclide to bone, thus providing a skeletal imaging agent.

  可用作锝-99m闪烁成像剂的稳定组合物由龙胆二酸或其药学上可接受的盐或酯与过硫酸盐还原剂结合而成，或溶于过硫酸盐-99m（ssmTcO4）溶液中。 这种组合物与磷酸盐或膦酸盐材料结合特别有用，可将放射性核素带入骨骼，从而提供骨骼成像剂。