N-{2-amino-5-(4-t-butyloxycarbonyl-1,4-diazepan-1-yl)-phenyl}benzenesulfonamide | 475279-13-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-{2-amino-5-(4-t-butyloxycarbonyl-1,4-diazepan-1-yl)-phenyl}benzenesulfonamide
• 英文别名: N-(2-amino-5-(4-t-butyloxycarbonyl-1,4-diazepan-1-yl)-phenyl}benzenesulfonamide；tert-butyl 4-[4-amino-3-(benzenesulfonamido)phenyl]-1,4-diazepane-1-carboxylate
• CAS: 475279-13-1
• 化学式: C₂₂H₃₀N₄O₄S
• 分子量: 446.571
• InChiKey: WZDZWGKUQXAYCJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  113
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  N-{2-amino-5-(4-t-butyloxycarbonyl-1,4-diazepan-1-yl)-phenyl}benzenesulfonamide 生成 N-{4-(1,4-diazepan-1-yl)-2-[(phenylsulfonyl)amino]phenyl }-2-naphthalenesulfonamide hydrochloride
  参考文献：
  名称：

  New compounds

  摘要：

  本发明涉及通式(I)或通式(II)的取代双芳基磺酰胺和芳基磺酰胺化合物，这些化合物可能对预防和治疗与肥胖、2型糖尿病和/或中枢神经系统紊乱相关的医疗状况有用。

  公开号：

  US20030149019A1

文献信息

• NEW COMPOUNDS
  申请人：Bremberg Ulf

  公开号：US20080096873A1

  公开（公告）日：2008-04-24

  The present invention relates to substituted bis-arylsulfonamide and arylsulfonamide compounds of the general formula (I) or the formula (II), which compounds are potentially useful for the prophylaxis and treatment of medical conditions relating to obesity, type II diabetes and/or disorders of the central nervous system.

  本发明涉及通式(I)或通式(II)的取代双芳基磺酰胺和芳基磺酰胺化合物，这些化合物可能有助于预防和治疗与肥胖、2型糖尿病和/或中枢神经系统疾病有关的医疗条件。
• Arylsulfonamide compounds
  申请人：Biovitrum AB

  公开号：US07173035B2

  公开（公告）日：2007-02-06

  The present invention relates to substituted bis-arylsulfonamide and arylsulfonamide compounds of the general formula (I) or the formula (II), which compounds are potentially useful for the prophylaxis and treatment of medical conditions relating to obesity, type II diabetes and/or disorders of the central nervous system.

  本发明涉及一些通式(I)或通式(II)的取代双芳基磺酰胺和芳基磺酰胺化合物，这些化合物可能对预防和治疗与肥胖、2型糖尿病和/或中枢神经系统疾病相关的医疗状况有用。
• Compounds
  申请人：Biovitrum AB

  公开号：US07319097B2

  公开（公告）日：2008-01-15

  The present invention relates to substituted bis-arylsulfonamide and arylsulfonamide compounds of the general formula (I) or the formula (II), which compounds are potentially useful for the prophylaxis and treatment of medical conditions relating to obesity, type II diabetes and/or disorders of the central nervous system

  本发明涉及一种通式（I）或通式（II）的取代双芳基磺酰胺和芳基磺酰胺化合物，这些化合物可能有助于预防和治疗与肥胖、2型糖尿病和/或中枢神经系统疾病有关的医疗状况。
• Substituted sulfonamide compounds useful for the prophylaxis and treatment of conditions relating to obesity, type II diabetes and/or disorders of the central nervous system
  申请人：Biovitrum AB

  公开号：US07566715B2

  公开（公告）日：2009-07-28

  The present invention relates to substituted bis-arylsulfonamide and arylsulfonamide compounds of the general formula (I) or the formula (II), which compounds are potentially useful for the prophylaxis and treatment of medical conditions relating to obesity, type II diabetes and/or disorders of the central nervous system.

  本发明涉及一种具有一般式(I)或式(II)的取代双芳基磺酰胺和芳基磺酰胺化合物，这些化合物可能有助于预防和治疗与肥胖、2型糖尿病和/或中枢神经系统紊乱相关的医疗状况。
• Aryl sulfonamide compounds for treating obesity
  申请人：Biovitrum AB

  公开号：US07718650B2

  公开（公告）日：2010-05-18

  The present invention relates to substituted bis-arylsulfonamide and arylsulfonamide compounds of the general formula (I) or the formula (II), which compounds are potentially useful for the prophylaxis and treatment of medical conditions relating to obesity, type II diabetes and/or disorders of the central nervous system.

  本发明涉及通式(I)或通式(II)的取代双芳基磺酰胺和芳基磺酰胺化合物，这些化合物可能有用于预防和治疗与肥胖、2型糖尿病和/或中枢神经系统疾病相关的医疗状况。