(2,5-Dioxopyrrolidin-1-yl) 4-(dioctadecylamino)-4-oxobutanoate | 79324-64-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (2,5-Dioxopyrrolidin-1-yl) 4-(dioctadecylamino)-4-oxobutanoate
• CAS: 79324-64-4
• 化学式: C₄₄H₈₂N₂O₅
• 分子量: 719.145
• InChiKey: KQPJBJPBODUSSE-UHFFFAOYSA-N

物化性质

• 沸点：
  751.0±62.0 °C(Predicted)
• 密度：
  0.98±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  16.3
• 重原子数：
  51
• 可旋转键数：
  39
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  84
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (2,5-Dioxopyrrolidin-1-yl) 4-(dioctadecylamino)-4-oxobutanoate 、 Phosphoric acid mono-{(3aR,4R,6R,6aR)-6-[6-(6-amino-hexylamino)-purin-9-yl]-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl} ester 在 三乙胺 作用下， 以 1,4-二氧六环 为溶剂， 生成 Phosphoric acid mono-((3aR,4R,6R,6aR)-6-{6-[6-(3-dioctadecylcarbamoyl-propionylamino)-hexylamino]-purin-9-yl}-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl) ester
  参考文献：
  名称：

  ATP-LipidsProtein Anchor and Energy Source in Two Dimensions

  摘要：

  The ubiquitous function of ATP as energy equivalent in nature has resulted in a common folding pattern of ATP-binding proteins. Their binding pocket tolerates modifications of the adenine ring to some extend, whereas those of the triphosphate group strongly affect the binding affinity. In consequence, immobilized C8- and N-6- modified ATP analogues are frequently used for affinity purification of ATPases or kinases. To combine this unique recognition principle with the fascinating properties of self-assembly, we have synthesized a novel class of hydrolyzable and nonhydrolyzable ATP-lipids where the nucleotides are covalently attached via C8- or N-6-position of the adenine ring to a synthetic lipid. These ATP-lipids were characterized by various enzyme assays in micellar solution, resulting in ATPase and competition activities that are comparable to their free counterparts. The specific docking of actin as a model of an ATP-binding protein to ATP-lipid monolayers was followed by film balance technique and epifluorescence microscopy. Based on this specific interaction, actin-supported membranes were generated to study shape transitions of vesicular systems. Due to the coupling of actin to ATP-lipid bilayers drastic changes in the viscoelastic properties and shape transitions were observed by phase contrast microscopy. These results underline the properties of these novel ATP-lipids as protein anchor or energy source in two dimensions. They can be applied either to form phantom cells, actin-supported membranes or to orient and crystallize ATP-binding proteins at lipid interfaces.

  DOI：

  10.1021/ja953937m
• 作为产物：
  描述：

  双十八烷基胺 在 N,N'-二环己基碳二亚胺 作用下， 以 吡啶 、 二氯甲烷 为溶剂， 反应 2.5h， 生成 (2,5-Dioxopyrrolidin-1-yl) 4-(dioctadecylamino)-4-oxobutanoate
  参考文献：
  名称：

  CHELATE NANOEMULSION FOR MRI

  摘要：

  本发明涉及一种用于磁共振成像的油包水纳米乳液组合物，包括： 水相，表示组合物重量的70%至90%，优选75%至85%，更优选78%至82%； 脂相包括一种油，表示组合物重量的9.5%至29.5%，优选14%至25%，更优选17%至21%； 表面活性剂位于水相和脂相之间的界面上，表面活性剂包括至少一种两性磁性金属螯合物和可选的两性脂质； 相对于油的重量，表面活性剂的总含量在4%至10%之间，优选在5%至8%之间； 相对于组合物的重量，表面活性剂的总含量在0.35%至2.95%之间，优选在0.5%至2%之间； 油包括至少70%，优选至少80%，优选至少95%的饱和C6-C18，优选C6-C14，更优选C6-C10脂肪酸。

  公开号：

  US20130309176A1

文献信息

• Nucleophilic Cleavage of Phosphate Triesters in Dialkylammonium Bilayer Membranes
  作者：Yoshio Okahata、Hirotaka Ihara、Toyoki Kunitake

  DOI：10.1246/bcsj.54.2072

  日期：1981.7

  on the reaction of p-nitrophenyl phosphates with hydroxamate nucleophiles in water in the presence of dialkylammonium bilayer membranes. With ethyl bis(p-nitrophenyl) phosphate, clean second order kinetics was observed for all the hydroxamate nucleophiles, two equivalents of p-nitrophenol being released in most cases. In contrast, a complex kinetics was observed for octadecylbis(p-nitrophenyl)phosphate

  在二烷基铵双层膜的存在下，对磷酸对硝基苯酯与异羟肟酸盐亲核试剂在水中的反应进行了研究。对于双（对硝基苯基）磷酸乙酯，所有异羟肟酸酯亲核试剂均观察到干净的二级动力学，在大多数情况下释放了两当量的对硝基苯酚。相反，观察到十八烷基双（对硝基苯基）磷酸酯的复杂动力学。长链异羟肟酸酯对这种长链底物的第二次切割过程受基质膜流动性的影响，在 Arrhenius 图中在 2C16N+2C1 膜的相变温度 (Tc) 附近存在一个拐点区域。在高于和低于 Tc 的温度下，活化能分别为 14 和 21 kcal/mol。
• NUCLEIC ACID AMPHIPHILES AND NANOSTRUCTURES
  申请人：KOKKOLI Efrosini

  公开号：US20170218367A1

  公开（公告）日：2017-08-03

  Provided herein are nucleic acid amphiphiles and nanostructures such as nanotubes twisted nanotapes and helical nanotapes that comprise the amphiphiles as well as methods to deliver therapeutic agents with the nanostructures.