N-octyl-N-propyloctan-1-amine | 15959-39-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-octyl-N-propyloctan-1-amine
• 英文别名: dioctyl-propyl-amine；Dioctyl-propyl-amin；N-Propyldioctylamin；Propyldioctylamine
• CAS: 15959-39-4
• 化学式: C₁₉H₄₁N
• 分子量: 283.541
• InChiKey: JVHQABRJBCIYFO-UHFFFAOYSA-N

物化性质

• 沸点：
  174 °C(Press: 10 Torr)
• 密度：
  0.811±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  20
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-octyl-N-propyloctan-1-amine 、 碘甲烷 在 Amberlite IRA-400Cl 作用下， 以 二氯甲烷 、 甲醇 为溶剂， 反应 4.0h， 以40%的产率得到Methyl-dioctyl-propylazanium;chloride
  参考文献：
  名称：

  Structure−Activity Study To Develop Cationic Lipid-Conjugated Haloperidol Derivatives as a New Class of Anticancer Therapeutics

  摘要：

  Haloperidol (HP), a neuroleptic drug, shows high affinity toward sigma receptors (SR). HP and reduced-HP at higher concentration were known to induce apoptosis in SR-overexpressing carcinomas and melanomas. Herein, we report the development of cationic lipid-conjugated haloperidol as a new class of anticancer therapeutics. In comparison to HP, the C-8 carbon chain analogue (HP-C8) showed significantly high, SR-assisted antiproliferative activity against cancer cells via caspase-3-mediated apoptosis and down-regulation of pAkt. Moreover, melanoma tumor aggressiveness in HP-C8-treated mice was significantly lower than that in HP-treated mice. HP-C8 simultaneously reduced Akt-protein level and increased Bax/Bcl-2 ratio in vascular endothelial cells, thereby indicating a possible protein kinase down-regulatory and apoptosis inducing role in tumor-associated vascular cells. In conclusion, we developed sigma receptor-targeting cationic lipid-modified HP derivatives as a promising class of anticancer therapeutic that concurrently affects cancer and tumor environment associated angiogenic vascular cells through induction of apoptosis and Akt protein down-regulation.

  DOI：

  10.1021/jm101530j
• 作为产物：
  描述：

  辛胺 在 potassium carbonate 作用下， 以 二甲基亚砜 、 乙酸乙酯 为溶剂， 反应 36.0h， 生成 N-octyl-N-propyloctan-1-amine
  参考文献：
  名称：

  Structure−Activity Study To Develop Cationic Lipid-Conjugated Haloperidol Derivatives as a New Class of Anticancer Therapeutics

  摘要：

  Haloperidol (HP), a neuroleptic drug, shows high affinity toward sigma receptors (SR). HP and reduced-HP at higher concentration were known to induce apoptosis in SR-overexpressing carcinomas and melanomas. Herein, we report the development of cationic lipid-conjugated haloperidol as a new class of anticancer therapeutics. In comparison to HP, the C-8 carbon chain analogue (HP-C8) showed significantly high, SR-assisted antiproliferative activity against cancer cells via caspase-3-mediated apoptosis and down-regulation of pAkt. Moreover, melanoma tumor aggressiveness in HP-C8-treated mice was significantly lower than that in HP-treated mice. HP-C8 simultaneously reduced Akt-protein level and increased Bax/Bcl-2 ratio in vascular endothelial cells, thereby indicating a possible protein kinase down-regulatory and apoptosis inducing role in tumor-associated vascular cells. In conclusion, we developed sigma receptor-targeting cationic lipid-modified HP derivatives as a promising class of anticancer therapeutic that concurrently affects cancer and tumor environment associated angiogenic vascular cells through induction of apoptosis and Akt protein down-regulation.

  DOI：

  10.1021/jm101530j

文献信息

• CARBON FIBER-REINFORCED THERMOPLASTIC RESIN COMPOSITION, MOLDING MATERIAL, PREPREG, AND METHODS FOR PRODUCING SAME
  申请人：Toray Industries, Inc.

  公开号：EP2765155A1

  公开（公告）日：2014-08-13

  Provided are a carbon fiber-reinforced thermoplastic resin composition excellent in interfacial adhesion between carbon fiber and a thermoplastic resin and excellent in dynamic characteristics, and a molding material, a prepreg, and a method for producing the same. The carbon fiber-reinforced thermoplastic resin composition includes the following components (A) and (B), carbon fiber and a thermoplastic resin; component (A): (A1) a bifunctional or higher functional epoxy compound and/or (A2) an epoxy compound which has a monofunctional or higher epoxy group and has one or more types of functional groups selected from a hydroxyl group, an amide group, an imide group, a urethane group, a urea group, a sulfonyl group and a sulfo group; and component (B): 0.1 to 25 parts by mass, based on 100 parts by mass of the component (A), of at least one reaction accelerator selected from the group consisting of [a] a specific tertiary amine compound (salt) (B1),[b] a specific quaternary ammonium salt (B2) and [c] a quaternary phosphonium salt and/or phosphine compound (B3).

  本发明提供了一种碳纤维增强热塑性树脂组合物，该组合物在碳纤维和热塑性树脂之间具有优异的界面粘合性和动态特性，还提供了一种成型材料、预浸料和生产方法。碳纤维增强热塑性树脂组合物包括以下组分（A）和（B）、碳纤维和热塑性树脂；组分（A）：（A1）双官能团或更高官能团的环氧化合物和/或（A2）具有单官能团或更高官能团的环氧化合物，该环氧化合物具有选自羟基、酰胺基、酰亚胺基、氨基甲酸酯基、脲基、磺酰基和磺酰基的一种或多种官能团；组分（B）：（A1）具有单官能团或更高官能团的环氧化合物，该环氧化合物具有选自羟基、酰胺基、酰亚胺基、氨基甲酸酯基、脲基、磺酰基和磺酰基的一种或多种官能团：以 100 重量份的组分（A）为基数，0.1 至 25 重量份的至少一种反应促进剂，该促进剂选 自以下组别：[a] 特定的叔胺化合物（盐）（B1）；[b] 特定的季铵盐（B2）；[c] 季鏻盐和/或膦化合物（B3）。
• CARBON FIBER MOLDING MATERIAL, MOLDING MATERIAL, AND CARBON FIBER-STRENGTHENING COMPOSITE MATERIAL
  申请人：Toray Industries, Inc.

  公开号：EP2789648A1

  公开（公告）日：2014-10-15

  Provided is a carbon fiber forming raw material having excellent interfacial adhesion between carbon fibers and a thermosetting resin and capable of giving a molded article having excellent mechanical characteristics. The carbon fiber forming raw material is a carbon fiber forming raw material (Z) as a prepreg including sizing agent-coated carbon fibers and a thermosetting resin or a carbon fiber forming raw material (Y) as a forming material that includes sizing agent-coated carbon fibers and has a woven fabric form or a braid form. The sizing agent includes components (A) and (B). The component (A) is an epoxy compound having two or more epoxy groups or two or more types of functional groups. The component (B) is one or more compounds selected from the group consisting of a tertiary amine compound, a tertiary amine salt, a quaternary ammonium salt, a quaternary phosphonium salt, and a phosphine compound. The component (B) is contained in an amount of 0.1 to 25 parts by mass relative to 100 parts by mass of the component (A).

  本发明提供了一种碳纤维成型原料，该原料在碳纤维和热固性树脂之间具有极佳的界面粘附性，并能使成型品具有极佳的机械特性。该碳纤维成型原料是一种碳纤维成型原料（Z），作为预浸料，包括上浆剂包覆的碳纤维和热固性树脂；或者是一种碳纤维成型原料（Y），作为成型材料，包括上浆剂包覆的碳纤维，并具有编织物或编织物的形态。上浆剂包括组分（A）和（B）。组分（A）是具有两个或两个以上环氧基团或两种或两种以上官能团的环氧化合物。组分（B）是一种或多种化合物，选自由叔胺化合物、叔胺盐、季铵盐、季鏻盐和膦化合物组成的组。相对于 100 重量份的组分（A），组分（B）的含量为 0.1 至 25 重量份。
• Carbon fiber forming raw material, formed material, and carbon fiber-reinforced composite material
  申请人：TORAY INDUSTRIES, INC.

  公开号：US10184034B2

  公开（公告）日：2019-01-22

  The carbon fiber forming raw material is a carbon fiber forming raw material (Z) as a prepreg including sizing agent-coated carbon fibers and a thermosetting resin or a carbon fiber forming raw material (Y) as a forming material that includes sizing agent-coated carbon fibers and has a woven fabric form or a braid form. The sizing agent includes components (A) and (B). The component (A) is an epoxy compound having two or more epoxy groups or two or more types of functional groups. The component (B) is one or more compounds selected from the group consisting of a tertiary amine compound, a tertiary amine salt, a quaternary ammonium salt, a quaternary phosphonium salt, and a phosphine compound. The component (B) is contained in an amount of 0.1 to 25 parts by mass relative to 100 parts by mass of the component (A).

  碳纤维成型原料是一种碳纤维成型原料（Z），作为预浸料，包括涂有上浆剂的碳纤维和热固性树脂；或者是一种碳纤维成型原料（Y），作为成型材料，包括涂有上浆剂的碳纤维，并具有编织物或编织物的形态。上浆剂包括组分（A）和（B）。组分（A）是具有两个或两个以上环氧基团或两种或两种以上官能团的环氧化合物。组分（B）是一种或多种化合物，选自由叔胺化合物、叔胺盐、季铵盐、季鏻盐和膦化合物组成的组。相对于 100 重量份的组分（A），组分（B）的含量为 0.1 至 25 重量份。
• Borrows et al., Journal of the Chemical Society, 1947, p. 201
  作者：Borrows et al.

  DOI：——

  日期：——
• Synthesis of unsaturated amines from butadiene and allylamines in presence of palladium and nickel complexes
  作者：U. M. Dzhemilev、F. A. Selimov、A. Z. Yakupova、G. A. Tolstikov

  DOI：10.1007/bf00923386

  日期：1978.6