3,6,7-Trihydroxy-1-[(3-nitrophenyl)methoxy]xanthen-9-one | 1314917-69-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3,6,7-Trihydroxy-1-[(3-nitrophenyl)methoxy]xanthen-9-one
• CAS: 1314917-69-5
• 化学式: C₂₀H₁₃NO₈
• 分子量: 395.325
• InChiKey: URNDPXQSAZWIFU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  142
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2,4,5-三甲氧基苯甲酸 在 吡啶 、 盐酸 、 aluminum (III) chloride 、 氯化亚砜 、 四丁基氢氧化铵 、 吡啶盐酸盐 、 potassium carbonate 、 N,N-二异丙基乙胺 作用下， 以 甲醇 、 乙醚 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 66.0h， 生成 3,6,7-Trihydroxy-1-[(3-nitrophenyl)methoxy]xanthen-9-one
  参考文献：
  名称：

  Discovery of novel xanthone derivatives as xanthine oxidase inhibitors

  摘要：

  Xanthine oxidase is the key enzyme that catalyzes the oxidation of hypoxanthine to xanthine and then to uric acid. In this study, a series of xanthone derivatives were synthesized as effective and a new class of xanthine oxidase inhibitor. Compounds 8a, 8c, 8i, 8g and 8r showed good inhibition against xanthine oxidase. The presence of a cyano group at the para position of benzyl moiety turned out to be the preferred substitution pattern. Molecular modeling studies were performed to gain an insight into its binding mode with xanthine oxidase, and to provide the basis for further structure-guided design of new non-purine xanthine oxidase inhibitors associated with the xanthone framework. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.04.140

文献信息

• Discovery of novel xanthone derivatives as xanthine oxidase inhibitors
  作者：Lina Hu、Honggang Hu、Weifeng Wu、Xiaoyun Chai、Jianfei Luo、Qiuye Wu

  DOI：10.1016/j.bmcl.2011.04.140

  日期：2011.7

  Xanthine oxidase is the key enzyme that catalyzes the oxidation of hypoxanthine to xanthine and then to uric acid. In this study, a series of xanthone derivatives were synthesized as effective and a new class of xanthine oxidase inhibitor. Compounds 8a, 8c, 8i, 8g and 8r showed good inhibition against xanthine oxidase. The presence of a cyano group at the para position of benzyl moiety turned out to be the preferred substitution pattern. Molecular modeling studies were performed to gain an insight into its binding mode with xanthine oxidase, and to provide the basis for further structure-guided design of new non-purine xanthine oxidase inhibitors associated with the xanthone framework. (C) 2011 Elsevier Ltd. All rights reserved.