cis-1,3-dimethyl-2-(1-phenylethoxy)-1,3-diphenylisoindoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: cis-1,3-dimethyl-2-(1-phenylethoxy)-1,3-diphenylisoindoline
• 英文别名: 1,3-dimethyl-2-(1-phenylethoxy)-1,3-diphenylisoindoline；(1R,3S)-1,3-dimethyl-1,3-diphenyl-2-(1-phenylethoxy)isoindole
• 化学式: C₃₀H₂₉NO
• 分子量: 419.566
• InChiKey: XHHJVSJRTLXNRB-QLXQRJEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7
• 重原子数：
  32
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-甲基邻苯二甲酰亚胺 在 sodium tungstate 、 双氧水 、 lead dioxide 作用下， 以 甲醇 为溶剂， 反应 58.67h， 生成 cis-1,3-dimethyl-2-(1-phenylethoxy)-1,3-diphenylisoindoline
  参考文献：
  名称：

  Symmetrical Nitroxide Synthesis:  Meso versus d,l Diastereomer Formation

  摘要：

  The syntheses of Ct-symmetrical isoindoline nitroxide 2a and meso-isoindoline nitroxide 2b have been achieved by two different routes. The chiral Ct-symmetric nitroxide derives from the addition of a Grignard reagent from the least hindered face opposite the large phenyl group in nitrone intermediate 21, whereas the isoindoline 3b precursor to the meso nitroxide is formed by the addition of a Grignard reagent from the face opposite the large magnesium oxide group of the tight ion pair of iminium 19. The assignment of these structures is confirmed by preparation of several derivatives as well as by X-ray crystallography.

  DOI：

  10.1021/jo981614d

文献信息

• Development of a Universal Alkoxyamine for “Living” Free Radical Polymerizations
  作者：Didier Benoit、Vladimir Chaplinski、Rebecca Braslau、Craig J. Hawker

  DOI：10.1021/ja984013c

  日期：1999.4.1

  “living” or controlled polymerization of a wide range of vinyl monomers. Surveying a variety of different alkoxyamine structures led to α-hydrido derivatives based on a 2,2,5-trimethyl-4-phenyl-3-azahexane-3-oxy, 1, skeleton which were able to control the polymerization of styrene, acrylate, acrylamide, and acrylonitrile based monomers. For each monomer set, the molecular weight could be controlled from 1000

  对新型烷氧基胺的研究表明，硝基氧在介导各种乙烯基单体的“活性”或受控聚合方面发挥着关键作用。调查各种不同的烷氧基胺结构导致基于 2,2,5-trimethyl-4-phenyl-3-azahex-3-oxy, 1, 骨架的 α-氢化衍生物能够控制苯乙烯、丙烯酸酯的聚合、丙烯酰胺和丙烯腈基单体。对于每个单体组，分子量可以控制在 1000 到 200 000 amu 之间，多分散性通常为 1.05-1.15。基于上述单体的组合的嵌段和无规共聚物也可以用类似的控制来制备。与 2,2,6,6-四甲基哌啶氧基 (TEMPO) 相比，这些新系统代表了可在受控条件下聚合的单体范围的显着增加，并克服了与氮氧化合物介导的“活性”自由基程序相关的许多限制。单体选择和功能...
• Symmetrical Nitroxide Synthesis:  Meso versus <i>d</i>,<i>l</i> Diastereomer Formation
  作者：Rebecca Braslau、Vladimir Chaplinski、Patricia Goodson

  DOI：10.1021/jo981614d

  日期：1998.12.1

  The syntheses of Ct-symmetrical isoindoline nitroxide 2a and meso-isoindoline nitroxide 2b have been achieved by two different routes. The chiral Ct-symmetric nitroxide derives from the addition of a Grignard reagent from the least hindered face opposite the large phenyl group in nitrone intermediate 21, whereas the isoindoline 3b precursor to the meso nitroxide is formed by the addition of a Grignard reagent from the face opposite the large magnesium oxide group of the tight ion pair of iminium 19. The assignment of these structures is confirmed by preparation of several derivatives as well as by X-ray crystallography.