4-hydroxyfluorene | 28147-35-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 4-hydroxyfluorene
• 英文别名: 4-Hydroxy-fluoren；1-Hydroxyfluoren；Fluoren-ol-(4)；4-Fluorenol；9H-fluoren-4-ol
• CAS: 28147-35-5
• 化学式: C₁₃H₁₀O
• mdl: MFCD00032803
• 分子量: 182.222
• InChiKey: ANGFHRWEXHAILW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.076
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  9-hydroxy-9-ethynyl-9H-thioxanthene 、 4-hydroxyfluorene 在 4-甲基苯磺酸吡啶 作用下， 以 氯仿 为溶剂， 反应 2.5h， 以36%的产率得到spiro[fluoreno[4,3-b]pyran-2(7H),9'-[9H]thioxanthene]
  参考文献：
  名称：

  连续辐照光致变色螺旋[氟代吡喃-噻吨酮]的研究

  摘要：

  新茚并稠合螺[苯并吡喃噻吨]合成（参见图3a - d在方案3）和连续照射下评估其光致变色特性（表1）。当用Xe灯照射几分钟时，该系统的行为就像是由两种开放的彩色形式组成，具有不同的热漂白速率和不同的降解敏感性。辐照时间的增加会导致显着降解，并导致显色占主导地位的开放彩色形式具有更快的漂白速度。

  DOI：

  10.1002/hlca.200490128
• 作为产物：
  描述：

  4-乙酰氨基芴 生成 4-hydroxyfluorene
  参考文献：
  名称：

  Ionization Constants of Derivatives of Fluorene and Other Polycyclic Compounds²

  摘要：

  DOI：

  10.1021/jo01063a006

文献信息

• QUENCHER
  申请人：Wako Pure Chemical Industries, Ltd.

  公开号：US20170342031A1

  公开（公告）日：2017-11-30

  A quencher is disclosed having a compound represented by the following general formula (1): wherein R 5 each independently represent a halogen atom, an alkyl group, an alkoxy group, an alkylthio group, an amino group having a substituent or not having a substituent, a hydroxy group, an aryl group, an aryloxy group, or an arylalkyl group; R 6 represents a group having a polymerizable unsaturated group, a hydroxy group, or the like; Y 1 represents an oxygen atom, or the like; An − represents an anion; Ar 1 represents a specific ring structure; * and ** represent binding positions; Ar 2 represents a benzene ring, a naphthalene ring, or an anthracene ring; n 1 represents a specific integer; and the following structure (1-10) in the general formula (1) is an asymmetric structure; (wherein R 5 , Y 1 , Ar 1 , Ar 2 , n 1 , * and ** are the same as described above.).

  一种淬灭剂被公开，该淬灭剂具有以下一般公式(1)表示的化合物： 其中R5各自独立代表一个卤素原子、一个烷基团、一个烷氧基团、一个烷硫基团、一个带有或不带有取代基的氨基团、一个羟基、一个芳基团、一个芳氧基团或一个芳烷基团；R6代表一个具有可聚合不饱和基团、一个羟基或类似基团的集团；Y1代表一个氧原子或类似；An代表一个阴离子；Ar1代表一个特定的环结构；*和**代表结合位置；Ar2代表一个苯环、一个萘环或一个蒽环；n1代表一个特定的整数； 并且一般公式(1)中的以下结构(1-10)是一个不对称结构； (其中R5、Y1、Ar1、Ar2、n1、*和**与上述描述相同)。
• Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
  申请人：Merck & Co., Inc.

  公开号：US06207823B1

  公开（公告）日：2001-03-27

  The present invention relates to tricyclic carbapenem antibacterial agents in which the carbapenem nucleus is fused to a 6 membered carbocyclic ring. The compound is further substituted with various substituent groups including at least one cationic group. The compounds are represented by formula I: Pharmaceutical compositions and methods of use are also included.

  本发明涉及三环头孢菌素类抗菌剂，其中头孢菌素核与一个6元碳环并联。该化合物进一步被各种取代基取代，包括至少一个阳离子基团。这些化合物由式I表示。药物组合物和使用方法也包括在内。
• Oxygenation Reactions of Various Tricyclic Fused Aromatic Compounds Using Escherichia coli and Streptomyces lividans Transformants Carrying Several Arene Dioxygenase Genes
  作者：Kazutoshi SHINDO、Yasuo OHNISHI、Hyo-Kon CHUN、Haruko TAKAHASHI、Miki HAYASHI、Atsushi SAITO、Kazuo IGUCHI、Kensuke FURUKAWA、Shigeaki HARAYAMA、Sueharu HORINOUCHI、Norihiko MISAWA

  DOI：10.1271/bbb.65.2472

  日期：2001.1

  compounds), including various tricyclic fused aromatic compounds such as fluorene, dibenzofuran, dibenzothiophene, carbazole, acridene, and phenanthridine, were done using the cells of Escherichia coli transformants expressing several arene dioxygenase genes. E. coli carrying the phenanthrene dioxygenase (phdABCD) genes derived from the marine bacterium Nocardioides sp. strain KP7 converted all of these

  使用表达几种芳烃双加氧酶基因的大肠杆菌转化子的细胞，对包括各种三环稠合芳族化合物（例如芴，二苯并呋喃，二苯并噻吩，咔唑，a啶和菲啶）在内的芳烃（芳族化合物）进行了生物转化（生物转化）实验。带有从海洋细菌Nocardioides sp。衍生的菲双加氧酶（phdABCD）基因的大肠杆菌。菌株KP7转化了所有这些三环芳族化合物，而带有恶臭假单胞菌F1甲苯双加氧酶（todC1C2BA）基因或假拟疟原虫KF707联苯双加氧酶（bphA1A2A3A4）基因的大肠杆菌无法转化这些底物。出乎意料的是，大肠杆菌携带杂种双加氧酶（todC1 ::: 在甲苯和联苯双加氧酶之间具有亚基取代的bphA2A3A4）基因能够转化芴，二苯并呋喃和二苯并噻吩。还评估了携带菲双加氧酶基因的淡紫色链霉菌转化体的细胞对各种三环稠合芳族化合物的生物转化。该放线菌转化的能力与携带相应基因的大肠杆菌相似。用这些重组细菌细胞从芳香族化合
• PHOTOCHROMIC MATERIALS COMPRISING HALOALKYL GROUPS
  申请人：Petrovskaia Olga G.

  公开号：US20070278461A1

  公开（公告）日：2007-12-06

  Various non-limiting embodiments of the present invention relate to photochromic materials which include a haloalkyl group. More particularly, various non-limiting embodiments disclosed herein provide photochromic materials including an indeno-fused naphthopyran, such as, an indeno[2′,3′:3,4]naphtho[1,2-b] pyran, and a haloalkyl group bonded at the 13-position thereof, wherein the haloalkyl group is a perhalogenated group or a group represented by —O(CH 2 ) a (CX 2 ) b CT 3 , wherein T is a halogen, each X is independently hydrogen or halogen, a is an integer ranging from 1 to 10, and b is an integer ranging from 1 to 10. Other non-limiting embodiments disclosed herein provide photochromic composition and photochromic articles, such as, but not limited to ophthalmic lens, which include the disclosed photochromic materials and methods of making the same.

  本发明的各种非限制性实施例涉及包含卤代烷基的光致变色材料。更具体地，本文所披露的各种非限制性实施例提供包括吲哚并螺[1,2-b]吡喃基的光致变色材料，例如吲哚并螺[2′,3′:3,4]吡喃并在其13位上键合有卤代烷基的光致变色材料，其中卤代烷基是全氟化基团或由—O(CH2)a(CX2)bCT3表示的基团，其中T是卤素，每个X独立地是氢或卤素，a是从1到10的整数，b是从1到10的整数。本文所披露的其他非限制性实施例提供光致变色组合物和光致变色制品，例如但不限于包括所述光致变色材料的眼镜镜片等，以及制造这些制品的方法。
• Alteration of the Substrate Specificity of the Angular Dioxygenase Carbazole 1,9a-Dioxygenase
  作者：Hiromasa UCHIMURA、Tadafumi HORISAKI、Takashi UMEDA、Haruko NOGUCHI、Yusuke USAMI、Li LI、Tohru TERADA、Shugo NAKAMURA、Kentaro SHIMIZU、Tetsuo TAKEMURA、Hiroshi HABE、Kazuo FURIHATA、Toshio OMORI、Hisakazu YAMANE、Hideaki NOJIRI

  DOI：10.1271/bbb.80512

  日期：2008.12.23

  Carbazole 1,9a-dioxygenase (CARDO) consists of terminal oxygenase (CARDO-O) and electron transport components. CARDO can catalyze specific oxygenation for various substrates: angular dioxygenation for carbazole and dibenzo-p-dioxin, lateral dioxygenation for anthracene, and monooxygenation for methylene carbon of fluorene and sulfide sulfur of dibenzothiophene. To elucidate the molecular mechanism determining its unique substrate specificity, 17 CARDO-O site-directed mutants at amino acid residues I262, F275, Q282, and F329, which form the substrate-interacting wall around the iron active site by CARDO-O crystal structure, were generated and characterized. F329 replacement dramatically reduced oxygenation activity. However, several mutants produced different products from the wild-type enzyme to a large extent: I262V and Q282Y (1-hydroxycarbazole), F275W (4-hydroxyfluorene), F275A (unidentified cis-dihydrodiol of fluoranthene), and I262A and I262W (monohydroxydibenzothiophenes). These results suggest the possibility that the respective substrates bind to the active sites of CARDO-O mutants in a different orientation from that of the wild-type enzyme.

  Carbazole 1,9a-二氧化酶（CARDO）由末端氧化酶（CARDO-O）和电子传递组件组成。CARDO能够对多种底物催化特定的氧化反应：对喹啉和二苯并-对-二氧的角氧化，对蒽的侧氧化，以及对弗鲁安的亚甲基碳和二苯并噻吩的硫的单氧化。为了阐明决定其独特底物特异性的分子机制，生成并表征了17个CARDO-O的定点突变体，这些突变体位于氨基酸残基I262、F275、Q282和F329，这些残基通过CARDO-O的晶体结构形成围绕铁活性位点的底物相互作用壁。F329的替换显著降低了氧化活性。然而，几个突变体与野生型酶相比，产生了不同的产物：I262V和Q282Y（1-羟基喹啉），F275W（4-羟基弗鲁安），F275A（未鉴定的弗鲁安烯顺式二氢二醇），以及I262A和I262W（单羟基二苯并噻吩）。这些结果表明，不同底物可能以不同于野生型酶的取向结合在CARDO-O突变体的活性位点。