4-Monomethylamino-N-methyl-phthalimid | 2487-72-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 4-Monomethylamino-N-methyl-phthalimid
• 英文别名: 4-monomethylamino-N-methyl phthalimide；2-Methyl-5-(methylamino)-1H-isoindole-1,3(2H)-dione；2-methyl-5-(methylamino)isoindole-1,3-dione
• CAS: 2487-72-1
• 化学式: C₁₀H₁₀N₂O₂
• mdl: MFCD11151562
• 分子量: 190.202
• InChiKey: YCOLGRLQJGCUFT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  甲醇 、 N-甲基-4-氨基邻苯二甲酰亚胺 在 C₂₁H₃₆BrMnNO₂P₂ 、 potassium tert-butylate 作用下， 反应 16.0h， 以85%的产率得到4-Monomethylamino-N-methyl-phthalimid
  参考文献：
  名称：

  使用甲醇改进和常规锰催化的芳香胺的N-甲基化

  摘要：

  已经合成了一种新型的基于二甲基吡啶的锰PNP钳配合物，用于甲醇对芳香胺的选择性N-甲基化。使用借用氢方法学，可以以良好的收率选择性地选择不同功能化的苯胺衍生物。

  DOI：

  10.1002/chem.201605218

文献信息

• AMINE DERIVATIVES HAVING NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY AND THE USES THEREOF
  申请人：OKUNO Takayuki

  公开号：US20100273842A1

  公开（公告）日：2010-10-28

  This invention provides an anorectic or anti-obesity composition comprising a compound of the formula (I): a pharmaceutically acceptable salt or solvate thereof, wherein R 1 is optionally substituted lower alkyl, Y is —S(O) n — wherein n is 1 or 2, or —CO—, R 2 is hydrogen or lower alkyl, R 7 is hydrogen or lower alkyl, X is lower alkylene, lower alkenylene, arylene, cycloalkylene or the like, and Z is lower alkyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl or the like.
• AMINE DERIVATIVE HAVING NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY
  申请人：Okuno Takayuki

  公开号：US20100267945A1

  公开（公告）日：2010-10-21

  A compound of the formula (I): a pharmaceutically acceptable salt or solvate thereof, where R 1 is optionally substituted lower alkyl, Y is —S(O) 2 —, R 2 is hydrogen or optionally substituted lower alkyl, R 7 is hydrogen or optionally substituted lower alkyl, X is a group of the formula: where R 5 and R 6 are each independently hydrogen, a group of the formula: is optionally substituted cycloalkylene, p is 0, and q is 1 or 2, Z is optionally substituted carbocyclyl or optionally substituted heterocyclyl, and provided that a compound wherein Z is fused heterocyclyl consisting of three rings or optionally substituted pyrimidinyl is excluded.
• Improved and General Manganese‐Catalyzed N‐Methylation of Aromatic Amines Using Methanol
  作者：Jacob Neumann、Saravanakumar Elangovan、Anke Spannenberg、Kathrin Junge、Matthias Beller

  DOI：10.1002/chem.201605218

  日期：2017.4.24

  A novel lutidine‐based manganese PNP‐pincer complex has been synthesized for the selective N‐methylation of aromatic amines with methanol. Using borrowing hydrogen methodology, a selection of differently functionalized aniline derivatives is selectively methylated in good yields.

  已经合成了一种新型的基于二甲基吡啶的锰PNP钳配合物，用于甲醇对芳香胺的选择性N-甲基化。使用借用氢方法学，可以以良好的收率选择性地选择不同功能化的苯胺衍生物。