diphenyl (hydroxy(phenyl)methyl)phosphonate | 52364-32-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diphenyl (hydroxy(phenyl)methyl)phosphonate
• 英文别名: diphenoxyphosphoryl(phenyl)methanol
• CAS: 52364-32-6
• 化学式: C₁₉H₁₇O₄P
• 分子量: 340.315
• InChiKey: LGWPZWRZPMNUGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 海关编码：
  2931900090

反应信息

• 作为产物：
  描述：

  亚磷酸三苯酯 在 phosphonic acid 、 三乙胺 作用下， 生成 diphenyl (hydroxy(phenyl)methyl)phosphonate
  参考文献：
  名称：

  Conversion of Tertiary Phosphites to Secondary Phosphonates. Diphenyl Phosphonate¹

  摘要：

  DOI：

  10.1021/ja01521a028

文献信息

• Lanthanide Amido Complexes Incorporating Amino-Coordinate-Lithium Bridged Bis(indolyl) Ligands: Synthesis, Characterization, and Catalysis for Hydrophosphonylation of Aldehydes and Aldimines
  作者：Xiancui Zhu、Shaowu Wang、Shuangliu Zhou、Yun Wei、Lijun Zhang、Fenhua Wang、Zhijun Feng、Liping Guo、Xiaolong Mu

  DOI：10.1021/ic300137r

  日期：2012.7.2

  Two series of new lanthanide amido complexes supported by bis(indolyl) ligands with amino-coordinate-lithium as a bridge were synthesized and characterized. The interactions of [(Me3Si)2N]3LnIII(μ-Cl)Li(THF)3 with 2 equiv of 3-(CyNHCH2)C8H5NH in toluene produced the amino-coordinate-lithium bridged bis(indolyl) lanthanide amides [μ-[η1:η1:η1:η1-3-(CyNHCH2)Ind]2Li}Ln[N(SiMe3)2]2] (Cy = cyclohexyl,

  合成并表征了双（吲哚基）配体负载的两个新的镧系酰胺配合物，其氨基配位锂为桥。[（Me 3 Si）2 N] 3 Ln III（μ-Cl）Li（THF）3与2当量的3-（CyNHCH 2）C 8 H 5 NH在甲苯中的相互作用产生了氨基配位锂桥联反应二（吲哚基）镧系元素酰胺[μ - [η 1：η 1：η 1：η 1 -3-（CyNHCH 2）工业] 2李} LN [N（森达3）2 ] 2]（Cy =环己基，Ind =吲哚基，Ln = Sm（1），Eu（2），Dy（3），Yb（4））收率良好。的治疗[μ - [η 1：η 1：η 1：η 1 -3-（CyNHCH 2）工业] 2李} LN [N（森达3）2 ] 2 ]用THF，得到新的镧系元素络合物酰胺[μ - [η 1：η 1 -3-（CyNHCH 2）工业] 2的Li（THF）} LN [N（森达3）2 ] 2 ]（Ln为铕（5），镝（
• 一种稀土金属芳胺基化合物及其制备方法和应 用
  申请人：苏州大学

  公开号：CN103626806B

  公开（公告）日：2016-02-03

  一种稀土金属芳胺基化合物及其制备方法和应用。本发明公开了一种稀土金属芳胺基化合物，其特征在于，所述稀土金属芳胺基化合物的通式为(2,6-R12PhNH)5LnLi2(THF)2；其中，Ln为稀土金属，选自钕、钐、镱或钇中的一种；R1选自氢、甲基或异丙基中的一种；本发明优点在于该稀土金属芳胺基化合物结构明确，其制备方法中所采用的原料简单易得、价格便宜，且反应过程简单易操作，产物提纯方便、产率高；且该稀土金属芳胺基化合物作为单组分催化剂催化醛或者酮与亚磷酸酯的氢膦化反应的活性高，催化剂的用量少，产率高，且底物的普适性广，为α-羟基膦酸酯的合成提供了一种新的简便方法。
• <i>n</i>-BuLi as a Highly Efficient Precatalyst for Hydrophosphonylation of Aldehydes and Unactivated Ketones
  作者：Chengwei Liu、Yu Zhang、Qinqin Qian、Dan Yuan、Yingming Yao

  DOI：10.1021/ol5030713

  日期：2014.12.5

  as highly efficient precatalysts for the hydrophosphonylation reactions of aldehydes and unactivated ketones with dialkyl phosphite under mild conditions. For ketone substrates, a reversible reaction was observed, and the influence of catalyst loading and reaction temperature on the reaction equilibrium was studied in detail. Overall, the hydrophosphonylation reactions catalyzed by 0.1 mol % n-BuLi

  首次发现有机碱金属化合物可作为醛和未活化酮与亚磷酸二烷基酯在温和条件下进行氢膦酰化反应的高效预催化剂。对于酮类底物，观察到可逆反应，并详细研究了催化剂负载量和反应温度对反应平衡的影响。总体而言，由0.1 mol％n- BuLi催化的加氢羰基化反应可在5分钟内完成，适用于多种底物，并以高收率产生了一系列α-羟基膦酸酯。
• An Ni–PyBisulidine complex for the asymmetric hydrophosphonylation of aldehydes
  作者：Youmao Zeng、Ping Deng、Shixiong Zhang、Hong Yan、Guojuan Liang、Yan Xiong、Hui Zhou

  DOI：10.1039/c6ob01750a

  日期：——

  A novel Ni–PyBisulidine complex has been developed for the asymmetric hydrophosphonylation of aldehydes. A variety of aromatic, heteroaromatic, condensed-ring, α,β-unsaturated, and aliphatic aldehydes are found to be suitable substrates for the reaction, and the desired α-hydroxy phosphonates are obtained in up to 99% yield and 97% ee.

  已开发出一种新型的Ni-PyBisulidine复合物，用于醛的不对称氢膦酰化。发现各种芳族，杂芳族，稠环，α，β-不饱和和脂族醛是反应的合适底物，并且以高达99％的收率和97％的ee获得所需的α-羟基膦酸酯。
• Catalytic Enantioselective Pudovik Reaction of Aldehydes and Aldimines with Tethered Bis(8-quinolinato) (TBOx) Aluminum Complex
  作者：Joshua P. Abell、Hisashi Yamamoto

  DOI：10.1021/ja803859p

  日期：2008.8.13

  New chiral tethered bis(8-quinolinolato) (TBOx) aluminum(III) complexes effectively catalyze the addition of phosphites to aldehydes and aldimines to give enantioenriched alpha-hydroxy and a-amino phosphonates in high yields and enantioselectivities with unprecedented reactivity (TON = 100 as high as 200). The catalyst is optimized with the low catalyst loading of 0.5 - 1.0 mol %. The modular synthesis of the catalyst allows for potential to tune the reaction for maximum catalytic activity. To date there are few examples with broad substrate scopes that can catalyze both aldehydes and aldimines with such high selectivity and no reports utilizing such low catalyst loading.