Pt(PPh3)2(N,N-dimethylthiourea) | 212190-62-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Pt(PPh3)2(N,N-dimethylthiourea)
• 英文别名: N-methyl-1-methylazanidylmethanimidothioate;platinum(2+);triphenylphosphane
• CAS: 212190-62-0
• 化学式: C₃₉H₃₆N₂P₂PtS
• 分子量: 821.822
• InChiKey: ZGUUMUOUULJLMK-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  三苯基膦 在 Et₃N 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成 Pt(PPh3)2(N,N-dimethylthiourea)
  参考文献：
  名称：

  Synthesis and crystal structure of the first complex containing a chelating selenourea dianion ligand

  摘要：

  Reaction of N,N'-diphenylselenourea, PhNHC(Se)NHPh, with cis-[PtCl2(PPh3)(2)] and triethylamine in hot methanol gives the first example of a selenourea dianion complex, [Pt{SeC(=NPh)NPh}(PPh3)(2)] isolated as a yellow solid in high yield. The structure of the complex was determined by X-ray crystallography and found to be similar to the related thiourea dianion complex [Pt{SC(= NPh)NPh}(PPh3)(2)], with a Pt-Se-C-N four-membered ring. The antitumour activity (P388 murine leukaemia cells) of the selenourea dianion complex was determined, together with a small selection of related platinum(II) -thiourea dianion complexes (prepared by an analogous method) for comparison. The complex [Pt{SC(=NMe)NMe}(PPh3)(2)] showed high activity [IC(50)1.0 muM], with the other complexes showing moderate to low activity. (C) 2003 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/s0020-1693(03)00298-6

文献信息

• Organogold(III) Metallacyclic Chemistry. Part 3. Self-assembly of the nonametallic gold(III)-silver(I)-sulfido aggregates [{LAu(μ-S)2AuL}3Ag3X2]+ (L=cycloaurated N,N-dimethylbenzylamine ligand; X=Cl, Br), by thiourea desulfurisation
  作者：Maarten B. Dinger、William Henderson、Brian K. Nicholson、Ward T. Robinson

  DOI：10.1016/s0022-328x(98)00470-7

  日期：1998.6

  the gold(III) dihalide complexes [C6H3(CH2uX2] (R=OMe, H; X=Cl, Br) with N,N′-dimethylthiourea and silver(I) oxide in refluxing dichloromethane gave the novel gold(III) aggregate cations [[C6H3(CH2u(μ-S)]2}3Ag3X2]+, formed from the desulfurisation of the thiourea. The cations consist of three gold sulfide dimers doubly-bridged by three silver(I) cations, which in turn are triply-bridged by two halides

  二卤化金（III）络合物[C 6 H 3（CH 2 uX 2 ]（R = OMe，H; X = Cl，Br）与N，N'-二甲基硫脲和氧化银（I）在回流的二氯甲烷中的反应给出了新型金（III）聚集阳离子[[C 6 H 3（CH 2 u（μ- S）] 2 } 3 Ag 3 X 2 ] +由硫脲的脱硫形成。阳离子由三个被三个银（I）阳离子双桥联的硫化金二聚体组成，而三个银（I）阳离子又被两个卤化物三桥联。聚集体已通过1 H-和13 C-NMR光谱和电喷雾质谱（ESMS）进行了充分表征，这些离子显示出非常强的母离子，证明对锥电压诱导的断裂具有显着的回弹力。尽管不能明确确定抗衡阴离子的性质，但已经为两个实例确定了单晶X射线结构。两次X射线研究表明，顺式和反式异构体（相对于N，N（在Au 2 S 2基团的任一侧上的-二甲基苄胺配体）形式，尽管在每种情况下仅分离出一种异构体。为了将该化学与铂（II