4-thiobutyltriphenylphosphonium bromide | 168423-31-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-thiobutyltriphenylphosphonium bromide
• 英文别名: (4-mercaptobutyl)triphenylphosphonium bromide；MTPB；Triphenyl(4-sulfanylbutyl)phosphanium bromide；triphenyl(4-sulfanylbutyl)phosphanium;bromide
• CAS: 168423-31-2
• 化学式: Br*C₂₂H₂₄PS
• 分子量: 431.376
• InChiKey: HILSVOIVEJVFOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.69
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-thiobutyltriphenylphosphonium bromide 在 盐酸 、 sodium nitrite 作用下， 以 乙醇 、 水 为溶剂， 生成 MitoSNO
  参考文献：
  名称：

  [EN] NITRIC OXIDE DONORS
  [FR] DONNEURS D'OXYDE NITRIQUE

  摘要：

  本发明涉及三苯基膦硫亚硝酸盐化合物，可选择性地将一氧化氮（NO）传递到线粒体。该发明的化合物包括一个亲脂性的三苯基膦阳离子，通过一个连接基与硫亚硝酸盐基团和一种药学上可接受的阴离子相连。这些化合物可用于治疗受NO活性影响的疾病，例如癌症、心脏病、认知障碍和中风。

  公开号：

  WO2010110684A1
• 作为产物：
  描述：

  (4-溴丁基)三苯基溴化膦 在 sodium hydrogensulfide 、 IRA-400 resin 、 ammonium chloride 作用下， 以 甲醇 为溶剂， 反应 18.0h， 以95%的产率得到4-thiobutyltriphenylphosphonium bromide
  参考文献：
  名称：

  A “Ready-To-Use” fluorescent-labelled-cysteine-TBTP (4-thiobutyltriphenylphosphonium) synthon to investigate the delivery of non-permeable PNA (peptide nucleic acids)-based compounds to cells

  摘要：

  This paper reports: (i) the facile synthesis of a cysteine synthon incorporating both a fluorescent group and a triphenylphosphonium derivative (TBTP) via the formation of a disulphide bond, which can subsequently undergo facile intracellular scission, (ii) the direct conjugation of this synthon to a non-permeable drug, (a cyclic PNA (peptide nucleic acid)-based compound has been chosen as a model), and (iii) that this conjugation enables the efficient homogenous delivery of the otherwise non-permeable cyclic PNA into the cytoplasm of cells, as demonstrated by fluorescence microscopy. Our results indicate that this fluorescent-labelled cysteine-TBTP synthon can provide a very useful tool for exploring the cellular uptake of a large range of molecules of biological interest, containing only a single reactive function. The preparation of an activated TBTP derivative is also described and this procedure could be widely used to introduce a TBTP cation to any thio-containing molecule. (c) 2007 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.bioorg.2007.01.002

文献信息

• Switching the subcellular organelle targeting of atomically precise gold nanoclusters by modifying the capping ligand
  作者：Ying Yang、Shuxin Wang、Shuang Chen、Yuhua Shen、Manzhou Zhu

  DOI：10.1039/c8cc04474k

  日期：——

  Here, we have achieved the target switching fluorescence imaging and photodynamic activity of hydrosoluble AuNCs from lysosomes to mitochondria through ligand exchange.

  在这里，我们通过配体交换，实现了亲水性金纳米簇从溶酶体向线粒体的靶向荧光成像和光动力活性。
• Modified Ion Exchange Resin and Process for Producing Bisphenols
  申请人：Terajima Takashi

  公开号：US20080051480A1

  公开（公告）日：2008-02-28

  There is provided a modified ion exchange resin catalyst which exhibits higher bisphenols selectivity than the conventional modified ion exchange resins in processes wherein bisphenols are produced by reacting a phenolic compound with ketones, and to provide such a process for producing bisphenols. A modified ion exchange resin is characterized in that at least one compound selected from (A) and (B) shown below is ionically bonded to an acidic functional group of an acidic ion exchange resin: (A) Compound represented by Formula (1) and (B) Compound represented by Formula (2)

  提供了一种改性离子交换树脂催化剂，该催化剂在酚类化合物与酮反应生产双酚时比传统的改性离子交换树脂表现出更高的双酚选择性，并提供一种生产双酚的工艺。改性离子交换树脂的特点在于，至少选择下列(A)和(B)中的一种化合物离子键结到酸性离子交换树脂的酸性官能团上：(A)公式（1）所表示的化合物和(B)公式（2）所表示的化合物。
• MODIFIED ION EXCHANGE RESIN AND PROCESS FOR PRODUCING BISPHENOLS
  申请人：TERAJIMA Takashi

  公开号：US20110224461A1

  公开（公告）日：2011-09-15

  There is provided a modified ion exchange resin catalyst which exhibits higher bisphenols selectivity than the conventional modified ion exchange resins in processes wherein bisphenols are produced by reacting a phenolic compound with ketones, and to provide such a process for producing bisphenols. A modified ion exchange resin is characterized in that at least one compound selected from (A) and (B) shown below is ionically bonded to an acidic functional group of an acidic ion exchange resin: (A) Compound represented by Formula (1) and (B) Compound represented by Formula (2)

  提供了一种改性离子交换树脂催化剂，其在通过将酚类化合物与酮反应生产双酚时表现出比传统改性离子交换树脂更高的双酚选择性，并提供了这样一种生产双酚的方法。改性离子交换树脂的特点在于，下列化合物之一（A）和（B）中至少选择一种离子键结到酸性离子交换树脂的酸性功能基团上：（A）由式（1）表示的化合物和（B）由式（2）表示的化合物。
• Mitochondrially targeted antioxidants
  申请人：University of Otago

  公开号：US20020052342A1

  公开（公告）日：2002-05-02

  The invention provides mitochondrially targeted antioxidant compounds. A compound of the invention comprises a lipophilic cation covalently coupled to an antioxidant moiety. In preferred embodiments, the lipophilic cation is the triphenyl phosphonium cation, and the compound is of the formula P(Ph 3 ) + XR.Z − where X is a linking group, Z is an anion and R is an antioxidant moiety. Also provided are pharmaceutical compositions containing the mitochondrially targeted antioxidant compounds, and methods of therapy or prophylaxis of patients who would benefit from reduced oxidative stress, which comprise the step of administering the compounds of the invention.

  本发明提供线粒体靶向抗氧化化合物。本发明的化合物包括与抗氧化剂分子共价偶联的亲脂阳离子。在优选的实施方案中，亲脂阳离子是三苯基鏻阳离子，化合物的化学式为 P(Ph 3 ) &plus； XR.Z - 其中 X 是连接基团，Z 是阴离子，R 是抗氧化剂分子。此外，还提供了含有线粒体靶向抗氧化剂化合物的药物组合物，以及治疗或预防可从降低氧化应激中获益的患者的方法，其中包括施用本发明化合物的步骤。
• WO2008/39085
  申请人：——

  公开号：——

  公开（公告）日：——