5-(4-(dimethylamino)phenyl)furan-2-carbaldehyde | 859441-85-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 5-(4-(dimethylamino)phenyl)furan-2-carbaldehyde
• 英文别名: 5-[4-(Dimethylamino)phenyl]-2-furaldehyde；5-[4-(dimethylamino)phenyl]furan-2-carbaldehyde
• CAS: 859441-85-3
• 化学式: C₁₃H₁₃NO₂
• 分子量: 215.252
• InChiKey: GZXGMBSLYRUHSG-UHFFFAOYSA-N

物化性质

• 沸点：
  381.3±37.0 °C(Predicted)
• 密度：
  1.150±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  33.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-甲基苯并噻唑 、 5-(4-(dimethylamino)phenyl)furan-2-carbaldehyde 在 氢氧化钾 作用下， 以 水 、 二甲基亚砜 为溶剂， 反应 3.5h， 以54%的产率得到(E)-2-{2-[5-(4-dimethylaminophenyl)-furan-2-yl]-vinyl}-benzothiazole
  参考文献：
  名称：

  Donor–π-acceptor benzothiazole-derived dyes with an extended heteroaryl-containing conjugated system: synthesis, DFT study and antimicrobial activity

  摘要：

  A series of novel derivatives containing an electron-donating N,N-dimethylaminophenyl ring connected to an electron-withdrawing benzothiazole or benzothiazolium moiety via a heteroaryl system (furan, thiophene or N-methylpyrrole) and up to two ethenylene groups have been synthesized and characterized. Furthermore, their nonlinear optical (NLO) properties have been investigated at the theoretical level using DFT and time-dependent DFT methods, and their antimicrobial activities were evaluated against a standard set of unicellular organisms. Both benzothiazole and benzothiazolium systems are predicted to exhibit large NLO responses, based on the calculated static molecular quadratic hyper-polarizabilities beta(0) as well as intramolecular charge transfer (ICT) transition characteristics. Moreover, the 3-alkyl-benzothiazolium salts were found to display high toxicity against several tested microbes. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.08.064
• 作为产物：
  描述：

  5-甲醛基呋喃-2-硼酸 、 4-溴-N,N-二甲基苯胺 在 bis-triphenylphosphine-palladium(II) chloride 、 potassium carbonate 作用下， 反应 12.0h， 以90%的产率得到5-(4-(dimethylamino)phenyl)furan-2-carbaldehyde
  参考文献：
  名称：

  近红外发射具有大斯托克斯位移的花青用于线粒体及其膜电位破坏的鉴定

  摘要：

  细胞线粒体的可视化在了解其动力学和功能方面起着关键作用。一种近红外发射、高度生物相容的荧光探针被成功开发并用于通过荧光共聚焦显微镜跟踪细胞中的线粒体功能障碍。该探针表现出优异的生物相容性和长期成像的高选择性。

  DOI：

  10.1002/cbic.202100516

文献信息

• [EN] PHENYLALANINE DERIVATIVES AND THEIR USE AS NON-PEPTIDE GLP-1 RECEPTOR MODULATORS<br/>[FR] DÉRIVÉS PHÉNYLALANINES ET LEUR UTILISATION COMME MODULATEURS NON PEPTIDIQUES DU RÉCEPTEUR DE GLP-1
  申请人：ARGUSINA INC

  公开号：WO2011094890A1

  公开（公告）日：2011-08-11

  Provided herein are non-peptide GLP-1 receptor modulator compounds, for example, of Formula (I), pharmaceutical compositions comprising such compounds, and processes of preparation thereof. Also provided are methods of their use for the treatment of a metabolic disorder.

  本文提供了非肽类GLP-1受体调节剂化合物，例如，Formula (I)的化合物，包括这些化合物的药物组合物，以及其制备方法。还提供了这些化合物用于治疗代谢紊乱的方法。
• CYCLIC CARBOXYLIC ACID RHODANINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF TUBERCULOSIS
  申请人：Singh Jasbir

  公开号：US20100210577A1

  公开（公告）日：2010-08-19

  Disclosed are methods for the prevention or treatment of tuberculosis in a subject infected with Mycobacterium tuberculosis by administering rhodanine derivatives of formula (I), as well as some novel such compounds. Other embodiments are also disclosed.

  公开了用于预防或治疗感染了结核分枝杆菌的受试者的结核病的方法，通过给予公式(I)的罗丹宁衍生物，以及一些新颖的此类化合物。还公开了其他实施例。
• Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation
  作者：Anzhalika Sidarovich、Cindy L Will、Maria M Anokhina、Javier Ceballos、Sonja Sievers、Dmitry E Agafonov、Timur Samatov、Penghui Bao、Berthold Kastner、Henning Urlaub、Herbert Waldmann、Reinhard Lührmann

  DOI：10.7554/elife.23533

  日期：——

  the stalled complexes (designated B028) revealed that U4/U6 snRNP proteins are released during activation before the U6 Lsm and B-specific proteins, and before recruitment and/or stable incorporation of Prp19/CDC5L complex and other Bact complex proteins. The U2/U6 RNA network in B028 complexes differs from that of the Bact complex, consistent with the idea that the catalytic RNA core forms stepwise

  前 mRNA 剪接的小分子抑制剂是识别新剪接体组装中间体的重要工具，可以更精细地剖析剪接体动力学和功能。在这里，我们鉴定了一种小分子，它在前催化剪接体 B 复合物转化为活化的 Bact 复合物的中间阶段抑制人前体 mRNA 剪接。停滞复合物（指定为 B028）的表征表明，U4/U6 snRNP 蛋白在 U6 Lsm 和 B 特异性蛋白之前的激活过程中以及在 Prp19/CDC5L 复合物和其他 Bact 复合物蛋白的募集和/或稳定掺入之前释放。B028 复合物中的 U2/U6 RNA 网络与 Bact 复合物中的不同，与催化 RNA 核心在 B 到 Bact 过渡期间逐步形成的想法一致，并且可能由 Prp19/CDC5L 复合物和相关蛋白质稳定。总之，我们的数据为剪接体激活过程中发生的 RNP 重排和广泛的蛋白质交换提供了新的见解。DOI：http://dx.doi.org/10.7554/eLife
• An efficient continuous flow approach to furnish furan-based biaryls
  作者：Trieu N. Trinh、Lacey Hizartzidis、Andrew J. S. Lin、David G. Harman、Adam McCluskey、Christopher P. Gordon

  DOI：10.1039/c4ob01641f

  日期：——

  Suzuki cross-couplings of 5-formyl-2-furanylboronic acid with activated or neutral aryl bromides were performed under continuous flow conditions in the presence of (Bu)₄N⁺F⁻and the immobilisedt-butyl based palladium catalyst CatCart™ FC1032™.

  直接给您结果：

  在连续流动条件下，在(Bu)₄N⁺F⁻和固定化的t-丁基基团钯催化剂CatCart™ FC1032™的存在下，使用活化或中性芳基溴化物对5-甲酰基-2-呋喃基硼酸进行了铃木偶联反应。

• A NIR Emitting Cyanine with Large Stokes’ Shift for Mitochondria and Identification of their Membrane Potential Disruption
  作者：Keti A. Bertman、Chathura S. Abeywickrama、Yi Pang

  DOI：10.1002/cbic.202100516

  日期：2022.1.19

  Visualization of cellular mitochondria plays a key role in understanding their dynamics and functions. An NIR-emitting, highly biocompatible fluorescent probe was successfully developed and utilized for tracking mitochondrial dysfunction in cells via fluorescence confocal microscopy. The probe exhibited excellent biocompatibility and high selectivity for long-term imaging.

  细胞线粒体的可视化在了解其动力学和功能方面起着关键作用。一种近红外发射、高度生物相容的荧光探针被成功开发并用于通过荧光共聚焦显微镜跟踪细胞中的线粒体功能障碍。该探针表现出优异的生物相容性和长期成像的高选择性。