di(p-t-butylbenzyl) trisulfide | 27639-74-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: di(p-t-butylbenzyl) trisulfide
• 英文别名: 1-Tert-butyl-4-[[(4-tert-butylphenyl)methyltrisulfanyl]methyl]benzene
• CAS: 27639-74-3
• 化学式: C₂₂H₃₀S₃
• 分子量: 390.678
• InChiKey: ZZKARVLUADUPLA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  25
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  75.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  对叔丁基苄硫醇 在 Di-1-imidazolyl-sulfid 作用下， 以96%的产率得到di(p-t-butylbenzyl) trisulfide
  参考文献：
  名称：

  Substituted organosulfur compounds and methods of using thereof

  摘要：

  本发明提供了取代二硫化物、三硫化物、四硫化物和五硫化物化合物及其组合物，以及利用它们用于治疗和/或预防细胞增殖性疾病的方法。本发明还提供了制备三硫化物化合物和组合物的方法。

  公开号：

  US20050261321A1

文献信息

• Trisulfides over disulfides: highly selective synthetic strategies, anti-proliferative activities and sustained H₂S release profiles
  作者：Debojit Bhattacherjee、Abu Sufian、Sulendar K. Mahato、Samiyara Begum、Kaustav Banerjee、Sharmistha De、Hemant Kumar Srivastava、Krishna P. Bhabak

  DOI：10.1039/c9cc05562b

  日期：——

  Temperature- and solvent-induced selective synthesis of trisulfides and disulfides is demonstrated. A remarkable selectivity was achieved using Na2S as a sulfur-transfer agent under mild, greener, catalyst-free and additive-free conditions. This study reveals trisulfides as a better model than disulfides in general for a sustained release of H2S and potent anti-cancer activities.

  证明了温度和溶剂诱导的三硫化物和二硫化物的选择性合成。使用Na 2 S作为硫转移剂，可在温和，绿色，无催化剂和无添加剂的条件下实现显着的选择性。这项研究表明，对于持续释放H 2 S和有效的抗癌活性，三硫化物通常比二硫化物更好。
• Synthesis and anti-tumor evaluation of new trisulfide derivatives
  作者：Haoyun An、Jenny Zhu、Xiaobo Wang、Xiao Xu

  DOI：10.1016/j.bmcl.2006.06.070

  日期：2006.9

  New bis-aromatic and heterocyclic trisulfide derivatives 5, 7-10 were synthesized by optimizing lead dibenzyl trisulfide natural product (4) to evaluate their anti-tumor activities. Five compounds 5-7, 9, and 10 exhibited potent anti-tumor activities against eight different tumor cell lines with low cytotoxicity against HepG2. Initial SAR was discussed, and MOA of these anti-microtubule agents was

  通过优化二苄基三硫化铅天然产物（4）合成了新的双芳族和杂环三硫化物衍生物5、7-10，以评估其抗肿瘤活性。五个化合物5-7、9和10对八种不同的肿瘤细胞系表现出有效的抗肿瘤活性，且对HepG2的细胞毒性较低。讨论了初始SAR，并根据在RT-CES系统上观察到的细胞动力学反应模式，提出了这些抗微管药的MOA。
• Cross‐Talks Between Sulfane Sulfur and Thiol at a Zinc(II) Site
  作者：Tuhin Sahana、Dhanusree C. Kakkarakkal、Subrata Kundu

  DOI：10.1002/chem.202200776

  日期：2022.7

  A tripodal [ZnII] complex has been demonstrated to assist cross-talks between sulfane sulfur and thiol under ambient base-free conditions, thereby revealing new possible roles of [ZnII] coordination motifs in thiol persulfidation, polysulfide formation, and its cross-over with free thiol relevant to sulfur biochemistry.

  三足 [Zn II ]配合物已被证明有助于在环境无碱条件下硫烷硫和硫醇之间的串扰，从而揭示 [Zn II ] 配位基序在硫醇过硫化、多硫化物形成及其交叉反应中的新可能作用。与硫生物化学相关的游离硫醇。
• Sirakawa,K. et al., Chemical and pharmaceutical bulletin, 1970, vol. 18, # 2, p. 235 - 242
  作者：Sirakawa,K. et al.

  DOI：——

  日期：——
• SUBSTITUTED ORGANOSULFUR COMPOUNDS AND METHODS OF USING THEREOF
  申请人：XU Xiao

  公开号：US20090192146A1

  公开（公告）日：2009-07-30

  The present invention provides substituted di-, tri-, tetra- and penta-sulfide compounds and compositions, and methods of using the same for the treatment and/or prevention of a cell proliferative disorder. The present invention also provides methods for preparing trisulfide compounds and compositions.