2,2-diethyl-5,5-dimethylpiperidin-4-one | 244020-98-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 2,2-diethyl-5,5-dimethylpiperidin-4-one
• 英文别名: 2,2-diethyl-6,6-dimethyl-4-piperidone；2,2-diethyl-6,6-dimethylpiperidin-4-one；2,2-dimethyl-6,6-diethyl-4-oxopiperidine
• CAS: 244020-98-2
• 化学式: C₁₁H₂₁NO
• 分子量: 183.294
• InChiKey: BPAVPPMLBNUUIR-UHFFFAOYSA-N

物化性质

• 沸点：
  246.0±15.0 °C(Predicted)
• 密度：
  0.868±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,2-diethyl-5,5-dimethylpiperidin-4-one 在 sodium hydroxide 、 乙酸乙酯 、 氯化钠 、 magnesium sulfate 作用下， 以 甲醇 为溶剂， 30.0~60.0 ℃ 、666.61 kPa 条件下， 以15.8 g (99%) 2,2-dimethyl-6,6-diethyl-4-hydroxypiperidine are obtained as yellowish oil的产率得到2,2-dimethyl-6,6-diethyl-4-hydroxypiperidine
  参考文献：
  名称：

  1-alkoxy-polyalkyl-piperidine derivatives and their use as polymerization regulators

  摘要：

  本发明涉及含有式(I)结构元素的1-烷氧基-多烷基-哌啶衍生物，其中G1、G2、G3、G4独立地为C1-C6烷基，但至少有一个不是甲基，或G1和G2或G3和G4，或G1和G2和G3和G4在一起形成C5-C12环烷基；G5、G6独立地为H、C1-C18烷基、苯基、萘基或COOC1-C18烷基，X表示一个基团，使得从X衍生出的自由基X能够引发乙烯基不饱和单体的聚合，但化合物A1和A2被排除在外。 本发明的另外主题是包括a）至少一个乙烯基不饱和单体和b）1-烷氧基-多烷基-哌啶衍生物的可聚合组合物、聚合乙烯基不饱和单体的方法，以及使用1-烷氧基-多烷基-哌啶衍生物进行可控聚合。中间体N-氧化物衍生物、N-氧化物衍生物与乙烯基不饱和单体的组合物和自由基引发剂X.，以及聚合的方法也是本发明的主题。

  公开号：

  US20020107397A1
• 作为产物：
  描述：

  1,2,2,6,6-五甲基-4-哌啶酮 在 盐酸 、 甲醇 、 水 、 氯化铵 、 对甲苯磺酸 作用下， 以 二甲基亚砜 、 丙酮 、 苯 为溶剂， 反应 24.5h， 生成 2,2-diethyl-5,5-dimethylpiperidin-4-one
  参考文献：
  名称：

  哌啶一氧化氮的结构反应性关系：电化学，ESR和计算研究

  摘要：

  我们合成了几种具有不同取代基的氮氧化物，这些氮氧化物会改变N-O部分周围的空间和电子环境，并系统地研究了取代基对自由基稳定性的作用。我们的结果表明，抗坏血酸的反应性与衍生物的氧化还原电位有关。此外，从头算还表明还原率与计算出的单占据分子轨道-最低未占据分子轨道能隙之间存在相关性，但与N-O部分的溶剂可及表面积无关，这支持了实验结果并表明电子因素在很大程度上决定了自由基的稳定性。因此，可以对氮氧化物进行虚拟筛选以优化其稳定性，

  DOI：

  10.1021/jo101961m

文献信息

• 1-alkoxy-polyallkyl-piperidine derivatives and their use as polymerization regulators
  申请人：Ciba Specialty Chemicals Corporation

  公开号：US06353107B1

  公开（公告）日：2002-03-05

  The present invention relates to 1-alkoxy-polyalkyl-piperidine derivatives containing a structural element of formula (I) wherein G1, G2, G3, G4 are independently C1-C6alkyl with the proviso that at least one is not methyl or G1 and G2 or G3 and G4, or G1 and G2 and G3 and G4 together form a C5-C12cycloalky group; G5, G6 independently are H, C1-C18alkyl, phenyl, naphthyl or a group COOC1-C18alkyl and X represents a group such that the free radical X. derived from X is capable of initiating polymerization of ethylenically unsaturated monomers, with the proviso that compounds A1 and A2 are excluded Further subjects of the invention are a polymerizable composition comprising a) at least one ethylenically unsaturated monomer and b) a 1-alkoxy-polyalkyl-piperidine derivative, a process for polymerizing ethylenically unsaturated monomers, and the use of 1-alkoxy-polyalkyl-piperidine derivatives for controlled polymerization. The intermediate N-oxyl derivatives, a composition of the N-oxyl derivatives with ethylenically unsaturated monomers and a free radical initiator X., as well as a process for polymerization are also subjects of the present invention.

  本发明涉及含有结构元素的1-烷氧基-多烷基-哌啶衍生物（I） 其中 G1、G2、G3、G4独立地为C1-C6烷基，但至少有一个不是甲基，或者G1和G2或G3和G4，或者G1和G2和G3和G4一起形成C5-C12环烷基； G5、G6独立地为H、C1-C18烷基、苯基、萘基或COOC1-C18烷基，X代表一个使得从X得到的自由基X能够引发乙烯基不饱和单体聚合的基团，但排除化合物A1和A2 本发明的另一主题是包括a）至少一种乙烯基不饱和单体和b）1-烷氧基-多烷基-哌啶衍生物的可聚合组合物，一种聚合乙烯基不饱和单体的方法，以及1-烷氧基-多烷基-哌啶衍生物用于受控聚合的用途。中间体N-氧基衍生物，N-氧基衍生物与乙烯基不饱和单体的组合物和自由基引发剂X，以及一种聚合方法也是本发明的主题。
• Steric and Electronic Effects in Cyclic Alkoxyamines—Synthesis and Applications as Regulators for Controlled/Living Radical Polymerization
  作者：Christian Wetter、Johannes Gierlich、Christoph Alexander Knoop、Christoph Müller、Tobias Schulte、Armido Studer

  DOI：10.1002/chem.200305427

  日期：2004.3.5

  trimethylsilyl(TMS)-diazomethane. The use of the new alkoxyamines as regulators/initiators for radical polymerization is discussed. Efficient controlled and living polymerization of styrene and n-butyl acrylate was obtained with the six-membered tetraethyl alkoxyamine 13. Controlled polymerizations can be conducted even at 90 degrees C. In addition, alkoxyamine 13 can be used for the preparation of AB diblock

  描述了在烷氧基胺的α-N位置带有乙基的新的六元和七元环状烷氧基胺的合成。位阻六元环烷氧基胺合成的关键步骤是双膦酸酯1的Wadsworth-Horner-Emmons烯化反应。七元环烷氧基胺由相应的六元酮烷氧基胺通过与三甲基甲硅烷基环扩大而制得。 TMS）-重氮甲烷。讨论了使用新的烷氧基胺作为自由基聚合反应的调节剂/引发剂。用六元四乙基烷氧基胺13获得苯乙烯和丙烯酸正丁酯的有效的受控和活性聚合。即使在90℃下也可以进行受控的聚合。烷氧基胺13可用于制备具有窄多分散性的AB二嵌段和ABA三嵌段共聚物。讨论了较大的乙基取代环状烷氧基胺中N原子的α-位甲基对苯乙烯聚合反应（反应时间，PDI，CO键均相动力学）的影响。另外，还研究了新烷氧基胺的热分解。此外，描述了N，N-双甲硅烷基化的烷氧基胺的合成。甲硅烷基化的烷氧基胺不适合用作受控/活性自由基聚合的调节剂/引发剂。甲硅烷基化的烷氧基胺中的CO键比
• 1-Alkoxy-polyalkyl-piperidine derivatives and their use as polymerization regulators
  申请人：Kramer Andreas

  公开号：US20050131177A1

  公开（公告）日：2005-06-16

  The present invention relates to 1-alkoxy-polyalkyipiperidine derivatives containing a structural element of formula (I) G 1 , G 2 , G 3 , G 4 are Independently C 1 -C 6 alkyl with the proviso that at least one is not methyl or G 1 and G 2 or G 3 and G 4 , or G 1 and G 2 and G 3 and G 4 together form a C 5 -C 12 cycloalkyl group; G 5 , G 6 independently are H, C 1 -C 18 alkyl, phenyl, naphthyl or a group COOC 1 -C 18 alkyl and X represents a group such that the free radical Xe derived from X is capable of initiating polymerization of ethylenically unsaturated monomers, with the proviso that compounds A1 and A2 are excluded Further subjects of the invention are a polymerizable composition comprising a) at least one ethylenically unsaturated monomer and b) a 1-alkoxy-polyalkyl-piperidine derivative, a process for polymerizing ethylenically unsaturated monomers, and the use of 1-alkoxy-polyalkyl-piperidine derivatives for controlled polymerization. The intermediate N-oxyl derivatives, a composition of the N-oxyl derivatives with ethylenically unsaturated monomers and a free radical initiator X•, as well as a process for polymerization are also subjects of the present invention.

  本发明涉及一种含有结构元素公式（I）的1-烷氧基-多烷基哌啶衍生物，其中G1、G2、G3、G4独立地为C1-C6烷基，但至少有一个不是甲基，或者G1和G2或G3和G4，或者G1、G2、G3和G4共同形成一个C5-C12环烷基；G5、G6独立地为H、C1-C18烷基、苯基、萘基或COOC1-C18烷基，X代表一种基团，使得来自X的自由基Xe能够引发乙烯基不饱和单体的聚合，但化合物A1和A2被排除在外。本发明的另外几个方面包括：包括a）至少一种乙烯基不饱和单体和b）一种1-烷氧基-多烷基哌啶衍生物的可聚合组合物、聚合乙烯基不饱和单体的方法，以及使用1-烷氧基-多烷基哌啶衍生物进行控制聚合。本发明的中间体N-氧基衍生物、N-氧基衍生物与乙烯基不饱和单体和自由基引发剂X•的组合物，以及聚合的方法也是本发明的内容。
• 4-Imino-n-alkoxy or oxy-polyalkyl-piperidine compounds and their use as polymerization regulators
  申请人：——

  公开号：US20040176553A1

  公开（公告）日：2004-09-09

  The present invention relates to selected 4-imino-N-alkoxy-polyalkyl-peperidine compounds preparation, a polymerizable composition comprising a) at least one ethylenically unsaturated monomer and b) a 4-imino-N-alkoxy-polyalkyl-piperidine compound. Further aspects of the present invention are a process for polymerizing ethylenically unsaturated monomers, and the use of 4-imino-N-alkoxy-polyalkyl-piperidine compounds for controlled polymerization. The intermediate N-oxyl derivatives, a composition of the N-oxyl derivatives with ethylenically unsaturated monomers and a free radical initiator, as well as a process for polymerization are also subjects of the present invention. 1

  本发明涉及选择的4-亚氨基-N-烷氧基-聚烷基-哌啶化合物的制备，包括a）至少一种乙烯基不饱和单体和b）4-亚氨基-N-烷氧基-聚烷基-哌啶化合物的可聚合组合物。本发明的其他方面包括聚合乙烯基不饱和单体的过程，以及使用4-亚氨基-N-烷氧基-聚烷基-哌啶化合物进行控制聚合的方法。中间体N-氧代衍生物，N-氧代衍生物与乙烯基不饱和单体和自由基引发剂的组合物，以及聚合的过程也是本发明的主题。
• N-alkoxy-4, 4-dioxy-polyalkyl-piperidine compounds, with glycidyl or alkylcarbonyl groups as functional initiators for controlled radical polymerization
  申请人：Fuso Francesco

  公开号：US20070173570A1

  公开（公告）日：2007-07-26

  The present invention relates to selected glycidyl or carbonyl functional N-alkoxy-4,4-dioxy-polyalkyl-piperidine compounds forming an open chain or cyclic ketal structure, a polymerizable composition comprising a) at least one ethylenically unsaturated monomer and b) a glycidyl or carbonyl functional N-alkoxy-4,4-dioxy-polyalkyl-piperidine nitroxide initiator compound. Further aspects of the present invention are a process for polymerizing ethylenically unsaturated monomers and the use of glycidyl or carbonyl functional N-alkoxy-4,4-dioxy-polyalkyl-piperidine nitroxide initiators for radical polymerization.

  本发明涉及选择的含有环氧基或酮基的N-烷氧基-4,4-二氧基-聚烷基哌啶化合物，形成开链或环状的环缩酮结构，以及包括a) 至少一种乙烯基不饱和单体和b) 含有环氧基或酮基的N-烷氧基-4,4-二氧基-聚烷基哌啶亚硝酰化合物的可聚合组合物。本发明的其他方面包括聚合乙烯基不饱和单体的方法以及使用含有环氧基或酮基的N-烷氧基-4,4-二氧基-聚烷基哌啶亚硝酰化合物进行自由基聚合的方法。