2-(2-phenylhydrazono)-2-chloro-N-phenylacetamide | 132815-67-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-phenylhydrazono)-2-chloro-N-phenylacetamide
• 英文别名: C-phenylcarbamoyl-N-phenylhydrazonoyl chloride；(1Z)-2-Anilino-2-oxo-N-phenylethanehydrazonoyl chloride
• CAS: 132815-67-9
• 化学式: C₁₄H₁₂ClN₃O
• 分子量: 273.722
• InChiKey: PUKSXDOBWDDAGI-AQTBWJFISA-N

物化性质

• 密度：
  1.23±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  53.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(2-phenylhydrazono)-2-chloro-N-phenylacetamide 在 氢氧化钾 、 1-phenyl-3-(5-trifluoromethyl<1,2,4>triazol-3-yl)thiourea 作用下， 以 乙醇 为溶剂， 反应 0.25h， 生成 [(Z)-N-anilino-C-(phenylcarbamoyl)carbonimidoyl] (1E)-N,2-dianilino-2-oxoethanimidothioate
  参考文献：
  名称：

  Zohdi, Hussein F., Journal of Chemical Research, Miniprint, 1998, # 9, p. 2126 - 2139

  摘要：

  DOI：

文献信息

• Reactions With Hydrazonoyl Halides 45: Synthesis of Some New Triazolino[4,3‐<i>a</i>]pyrimidines, Pyrazolo[3,4‐<i>d</i>]pyridazines, Isoxazolo[3,4‐<i>d</i>]pyridazines, and Thieno[2,3‐<i>b</i>]pyridines
  作者：Abdou O. Abdelhamid、Ali A. Al‐Atoom

  DOI：10.1080/00397910500330593

  日期：2006.2

  Abstract Triazolino[4,3‐a]pyrimidines pyrazolo[3,4‐d]pyridazines and isoxazolo[3,4‐d]pyridazines were synthesized from hydrazonoyl halides. Also, 3‐aminothieno[2,3‐b]pyridines and pyrimidino[4′,5′:4,5]thieno[2,3‐b]pyridines were synthesized from cynothioacetamide. Structures of the newly synthesized compounds were established on the basis of elemental analyses and spectral data.

  摘要 三唑并[4,3-a]嘧啶类吡唑并[3,4-d]哒嗪和异恶唑并[3,4-d]哒嗪由腙酰卤化物合成。此外，3-氨基噻吩并[2,3-b]吡啶和嘧啶并[4',5':4,5]噻吩并[2,3-b]吡啶由犬硫代乙酰胺合成。新合成化合物的结构是在元素分析和光谱数据的基础上建立的。
• HETEROCYCLIC SYNTHESIS USING NITRILIMINES: PART 3(1). SYNTHESIS OF SUBSTITUTED 1,2,4,5-TETRAZINES AND 1,2,4,5-TETRAAZA-2-PENTENES
  作者：Hany M. Dalloul、Peter H. Boyle

  DOI：10.1515/hc.2003.9.5.507

  日期：2003.1

  The reaction of nitrilimines 2a.b with hydrazones of aliphatic ketones 3 (RHNN=CR'R) led to the formation of the cyclocondensation products 1,2,4,5-tetrazines 4a-g when R = CH3, and to acyclic electrophilic addition products 5a-g when R = H, rather than the cyclocondensation tetrazines products 8.

  当 R = CH3 时，腈亚胺 2a.b 与脂肪族酮 3 腙 (RHNN=CR'R) 的反应导致环缩合产物 1,2,4,5-四嗪 4a-g 的形成，以及非环状亲电加成当 R = H 时产物 5a-g，而不是环缩合四嗪产物 8。
• Simple and convenient routes to new polyheterocycles incorporating pyrazole, thiazole, thiophene, and 1,3,4-thiadiazole moieties
  作者：Zaghloul E. Kandeel、Kamal M. Dawood、Eman A. Ragab、Ahmad M. Farag

  DOI：10.1002/hc.10024

  日期：——

  The cyanothioacetanilide derivative 3 reacted readily with either α-halocarbonyl compounds 4 or α-halodicarbonyl compounds 8 to afford the same thiophene derivatives 6. Compound 3 also reacted with hydrazonoyl chlorides 12 and 16 and furnished the new polyheterocyles 14 and 17, respectively. © 2002 Wiley Periodicals, Inc. Heteroatom Chem 13:248–251, 2002; Published online in Wiley Interscience (www

  氰基硫代乙酰苯胺衍生物 3 很容易与 α-卤代羰基化合物 4 或 α-卤代二羰基化合物 8 反应，得到相同的噻吩衍生物 6。化合物 3 也与腙酰氯 12 和 16 反应，分别得到新的聚杂环 14 和 17。© 2002 Wiley Periodicals, Inc. 杂原子化学 13:248–251, 2002; 在线发表于 Wiley Interscience (www.interscience.wiley.com)。DOI 10.1002/hc.10024
• Regioselective synthesis of diazaspiro[4.4]nona‐ and tetrazaspiro[4.5]deca‐2,9‐diene‐6‐one derivatives
  作者：Ahmad M. Farag、Yehya M. Elkholy、Korany A. Ali

  DOI：10.1002/jhet.5570450134

  日期：2008.1

  4]nona-2,8-diene-6-one derivatives were synthesised via cycloaddition of nitrilimides to 3-aryliden-2(3H)-furanone derivatives. The formed products react with hydrazine hydrate to give the corresponding pyrazolecarbohydrazide derivatives which undergo intramolecure cyclization upon treatment with HCl/AcOH mixture to affored 1,2,7,8-tetrazaspiro[4.5]deca-2,9-diene-6-one derivatives. Molecular mechanics

  几个1，2-二氮杂螺[4，4] nona-2，8-二烯-6-一衍生物是通过将腈类化合物环加成到3-aryliden-2（3H）-呋喃酮衍生物上而合成的。形成的产物与水合肼反应，得到相应的吡唑碳酰肼衍生物，将其用HCl / AcOH混合物处理后进行分子内环化，得到1,2,7,8-四氮杂螺[4.5] deca-2,9-二烯-6-衍生物。化合物8-（4-甲基苯基）-1,3,4-三苯基-7-氧杂-1,2-二氮杂螺[4.4] nona-2,8-二烯-6-one的分子力学能量最小化技术及相关结构参数报告了5a。
• Novel Regioselective Synthesis and Biological Activity of 6-Phenylazo and 3,6-Bis(arylazo)-7-hydroxy-1H-[1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one
  作者：Sayed M. Riyadh

  DOI：10.1002/jccs.200500080

  日期：2005.6

  hydrazonoyl halides 2 and N,2-diaryl-diazinecarbohydrazonoyl halides 9 in dioxane in the presence of triethylamine under reflux furnishes 6-phenylazo and 3,6-bis(arylazo)-7-hydroxy-1H-[1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one derivatives 7 and 10, respectively. The biological activities of the products were evaluated.

  6-羟基-5-苯基偶氮-2-硫代-4(1H)-嘧啶酮1与一系列肼酰卤2和N,2-二芳基-二嗪咔唑酰卤9在二恶烷中在三乙胺存在下回流提供6-苯偶氮和 3,6-bis(arylazo)-7-hydroxy-1H-[1,2,4]triazolo[4,3-a]pyrimidin-5(4H)-one 衍生物 7 和 10，分别。评价了产品的生物活性。