1-acetoxy-3-(1-naphthyloxy)propan-2-one | 204584-18-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-acetoxy-3-(1-naphthyloxy)propan-2-one
• 英文别名: (3-Naphthalen-1-yloxy-2-oxopropyl) acetate
• CAS: 204584-18-9
• 化学式: C₁₅H₁₄O₄
• 分子量: 258.274
• InChiKey: USWQWZXOUICFEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-acetoxy-3-(1-naphthyloxy)propan-2-one 在 baker's yeast 、 sodium phosphate buffer 、 蔗糖 作用下， 反应 2.0h， 以78%的产率得到(R)-3-(萘-1-氧基)丙烷-1,2-二醇
  参考文献：
  名称：

  Baker's yeast mediated stereoselective biotransformation of 1-acetoxy-3-aryloxypropan-2-ones

  摘要：

  A series of 1-acetoxy-3-aryloxypropan-2-ones la-m were synthesized and subjected to biotransformation by baker's yeast yielding optically active monoacetates 5 or ent-5 and/or diols 4 of moderate to excellent enantiomeric purity. The dependence of the reduction/hydrolysis ratio and stereoselectivity on the size and substitution pattern of the aromatic moiety in the substrate is also discussed. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(97)00626-5
• 作为产物：
  描述：

  3-(1-萘基氧基)-1,2-丙二醇 在 吡啶 、 4-二甲氨基吡啶 、 草酰氯 、 二甲基亚砜 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.83h， 生成 1-acetoxy-3-(1-naphthyloxy)propan-2-one
  参考文献：
  名称：

  Baker's yeast mediated stereoselective biotransformation of 1-acetoxy-3-aryloxypropan-2-ones

  摘要：

  A series of 1-acetoxy-3-aryloxypropan-2-ones la-m were synthesized and subjected to biotransformation by baker's yeast yielding optically active monoacetates 5 or ent-5 and/or diols 4 of moderate to excellent enantiomeric purity. The dependence of the reduction/hydrolysis ratio and stereoselectivity on the size and substitution pattern of the aromatic moiety in the substrate is also discussed. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0957-4166(97)00626-5

文献信息

• Baker's yeast mediated stereoselective biotransformation of 1-acetoxy-3-aryloxypropan-2-ones
  作者：Gabriella Egri、Attila Kolbert、József Bálint、Elemér Fogassy、Lajos Novák、László Poppe

  DOI：10.1016/s0957-4166(97)00626-5

  日期：1998.1

  A series of 1-acetoxy-3-aryloxypropan-2-ones la-m were synthesized and subjected to biotransformation by baker's yeast yielding optically active monoacetates 5 or ent-5 and/or diols 4 of moderate to excellent enantiomeric purity. The dependence of the reduction/hydrolysis ratio and stereoselectivity on the size and substitution pattern of the aromatic moiety in the substrate is also discussed. (C) 1998 Elsevier Science Ltd. All rights reserved.