(氯甲基)十二烷基二甲基-硅烷 | 70851-47-7

• 分子结构分类: 有机化合物 - 有机盐 - 有机金属盐
• 中文名称: (氯甲基)十二烷基二甲基-硅烷
• 中文别名: 氯甲基十二烷基二甲基硅烷
• 英文名称: chloromethyl-dimethyl-n-dodecyl-silane
• 英文别名: chloromethyldimethyldodecylsilane；chloromethyldodecyldimethylsilane；dodecyldimethylsilylmethylchloride；Silane, (chloromethyl)dodecyldimethyl-；chloromethyl-dodecyl-dimethylsilane
• CAS: 70851-47-7
• 化学式: C₁₅H₃₃ClSi
• 分子量: 276.966
• InChiKey: YUWMHVAIAHCLSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.39
• 重原子数：
  17
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  (氯甲基)十二烷基二甲基-硅烷 、 C60(CH2SiMe2C6H13)H 在 potassium tert-butylate 、 potassium iodide 作用下， 以 四氢呋喃 、 苯甲腈 为溶剂， 反应 12.17h， 以70%的产率得到1-(dimethylhexylsilylmethyl)-7-(dimethyldodecylsilylmethyl)-1,7-dihydro(C60-I_h)[5,6]fullerene
  参考文献：
  名称：

  Regioselective Synthesis of 1,4-Di(organo)[60]fullerenes through DMF-assisted Monoaddition of Silylmethyl Grignard Reagents and Subsequent Alkylation Reaction

  摘要：

  Monoaddition of Grignard reagents, in particular tri(organo)silylmethyl magnesium chlorides, to [60]fullerene took place smoothly in the presence of dimethylformamideto produce (organo)(hydro)[60]fullerenes, (C60RH)-H-1, in good yield (up to 93% isolated yield). The hydrofullerene was then deprotonated to generate the corresponding anion, C60R-, which was then alkylated to obtain 58 pi-electron di(organo)[60]fullerenes, (C60RR2)-R-1, in good to high yield (up to 93% overall yield). The two-step methodology provides a wide variety of 1,4-di(organo)[60] fullerenes bearing the same or different organic addends on the [60] fullerene core. By changing the addends, one can control the chemical and physical properties of the compounds at the molecular and bulk levels.

  DOI：

  10.1021/ja8041299

文献信息

• Method of lowering serum cholesterol levels with
  申请人：Hoechst Marion Roussel, Inc.

  公开号：US05677291A1

  公开（公告）日：1997-10-14

  A method of lowering plasma cholesterol level in a patient with hypercholesterolemia, by administration of a compound of formula (1) ##STR1## wherein: R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each independently a C.sub.1 -C.sub.6 alkyl group; Z is a thio, oxy or methylene group; A is a C.sub.1 -C.sub.4 alkylene group; and R.sub.5 is a C.sub.1 -C.sub.6 alkyl or --(CH.sub.2).sub.n --(Ar) wherein n is an integer 0, 1, 2 or 3; and Ar is phenyl or napthyl unsubstituted or substituted with one to three substituents selected from the group consisting of hydroxy, methoxy, ethoxy, chloro, fluoro or C.sub.1 -C.sub.6 alkyl.

  一种降低高胆固醇血症患者血浆胆固醇水平的方法，通过给予式(1)的化合物进行治疗，其中：R1、R2、R3和R4各自独立地为C1-C6烷基；Z为硫、氧或亚甲基基团；A为C1-C4烷基基团；R5为C1-C6烷基或--(CH2)n--(Ar)，其中n为整数0、1、2或3；Ar为苯基或萘基，未取代或取代有1-3个取自羟基、甲氧基、乙氧基、氯、氟或C1-C6烷基的取代基。
• Regioselective Synthesis of 1,4-Di(organo)[60]fullerenes through DMF-assisted Monoaddition of Silylmethyl Grignard Reagents and Subsequent Alkylation Reaction
  作者：Yutaka Matsuo、Akihiko Iwashita、Yoko Abe、Chang-Zhi Li、Keiko Matsuo、Masahiko Hashiguchi、Eiichi Nakamura

  DOI：10.1021/ja8041299

  日期：2008.11.19

  Monoaddition of Grignard reagents, in particular tri(organo)silylmethyl magnesium chlorides, to [60]fullerene took place smoothly in the presence of dimethylformamideto produce (organo)(hydro)[60]fullerenes, (C60RH)-H-1, in good yield (up to 93% isolated yield). The hydrofullerene was then deprotonated to generate the corresponding anion, C60R-, which was then alkylated to obtain 58 pi-electron di(organo)[60]fullerenes, (C60RR2)-R-1, in good to high yield (up to 93% overall yield). The two-step methodology provides a wide variety of 1,4-di(organo)[60] fullerenes bearing the same or different organic addends on the [60] fullerene core. By changing the addends, one can control the chemical and physical properties of the compounds at the molecular and bulk levels.
• MOBERG, W. K.
  作者：MOBERG, W. K.

  DOI：——

  日期：——