1-hydroxy-[2]naphthoic acid propyl ester | 73405-78-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-hydroxy-[2]naphthoic acid propyl ester
• 英文别名: 1-Hydroxy-[2]naphthoesaeure-propylester；Propyl 1-hydroxynaphthalene-2-carboxylate
• CAS: 73405-78-4
• 化学式: C₁₄H₁₄O₃
• mdl: MFCD06643706
• 分子量: 230.263
• InChiKey: IYBCVDZCMOWSHE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.214
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-hydroxy-[2]naphthoic acid propyl ester 在 硝酸 、 溶剂黄146 作用下， 生成 1-hydroxy-4-nitro-[2]naphthoic acid propyl ester
  参考文献：
  名称：

  Onset of spinal block is more rapid with isobaric than hyperbaric bupivacaine

  摘要：

  Purpose: To compare isobaric with hyperbaric 9.75 mg bupivacaine injected intrathecally, and to evaluate the effects of subsequent injection of lidocaine 2% into the epidural space.Methods: Patients in group I (n = 30) received isobaric 9.75 mg bupivacaine and in group 2 (n = 30) hyperbaric 9.75 mg bupivacaine injected into the subarachnoid space in a combined spinal-epidural technique, They were undergoing urological, gynecological, orthopedic, gastro-intestinal or vascular surgery. Using a double blind technique, the followings parameters were measured: cutaneous analgesia to pinprick, motor blockade, time for two segment regression, time for complete regression of the motor block, quality of anesthesia. In 12 patients the effect of epidural injections of 3 ml lidocaine 2% was observed.Results: Motor and sensory block developed more rapidly (five minutes) in the isobaric group (P < 0.05). Maximum upper level (T7 +/- 2), two-segment regression (52 min in both groups), motor recovery (160 vs 157 min), and quality of anesthesia did not differ between the two groups. Thirty nine epidural injections of 3 mi lidocaine 2% were given in 12 patients 10 min after spinal injection, 28 were in the hyperbaric group (P < 0.05). Twenty six of the epidural injections produced an increase in sensory block of 0 or 1 dermatome, and 13, of 2 or more.Conclusion: The block developed more rapidly in the isobaric group, but both isobaric and hyperbaric 9.75 mg bupivacaine produced adequate upper levels of analgesia for surgery. The effect of epidural injections of 3 mi lidocaine 2% was usually minimal.

  DOI：

  10.1007/bf03020730
• 作为产物：
  描述：

  1-羟基-2-萘甲酸 在 氯化亚砜 、 Petroleum ether 作用下， 生成 1-hydroxy-[2]naphthoic acid propyl ester
  参考文献：
  名称：

  77. 1-羟基-2-萘甲酸的酯和由其形成的萘酚蓝染料

  摘要：

  DOI：

  10.1039/jr9480000309

文献信息

• Onset of spinal block is more rapid with isobaric than hyperbaric bupivacaine
  作者：René Martin、Chantal Frigon、Angelo Chrétien、Jean-Pierre Tétrault

  DOI：10.1007/bf03020730

  日期：2000.1

  Purpose: To compare isobaric with hyperbaric 9.75 mg bupivacaine injected intrathecally, and to evaluate the effects of subsequent injection of lidocaine 2% into the epidural space.Methods: Patients in group I (n = 30) received isobaric 9.75 mg bupivacaine and in group 2 (n = 30) hyperbaric 9.75 mg bupivacaine injected into the subarachnoid space in a combined spinal-epidural technique, They were undergoing urological, gynecological, orthopedic, gastro-intestinal or vascular surgery. Using a double blind technique, the followings parameters were measured: cutaneous analgesia to pinprick, motor blockade, time for two segment regression, time for complete regression of the motor block, quality of anesthesia. In 12 patients the effect of epidural injections of 3 ml lidocaine 2% was observed.Results: Motor and sensory block developed more rapidly (five minutes) in the isobaric group (P < 0.05). Maximum upper level (T7 +/- 2), two-segment regression (52 min in both groups), motor recovery (160 vs 157 min), and quality of anesthesia did not differ between the two groups. Thirty nine epidural injections of 3 mi lidocaine 2% were given in 12 patients 10 min after spinal injection, 28 were in the hyperbaric group (P < 0.05). Twenty six of the epidural injections produced an increase in sensory block of 0 or 1 dermatome, and 13, of 2 or more.Conclusion: The block developed more rapidly in the isobaric group, but both isobaric and hyperbaric 9.75 mg bupivacaine produced adequate upper levels of analgesia for surgery. The effect of epidural injections of 3 mi lidocaine 2% was usually minimal.
• 77. Esters of 1-hydroxy-2-naphthoic acid, and naphthol-blue dyes therefrom
  作者：M. Pianka、H. C. Barany

  DOI：10.1039/jr9480000309

  日期：——