hexanamidine hydrochloride

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: hexanamidine hydrochloride
• 英文别名: Hexanimidamide hydrochloride；hexanimidamide;hydrochloride
• 化学式: C₆H₁₄N₂*ClH
• mdl: MFCD13193854
• 分子量: 150.651
• InChiKey: IQYXAKDFVUKMLW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.07
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.833
• 拓扑面积：
  49.9
• 氢给体数：
  3
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  hexanamidine hydrochloride 、 4-氯异硫氰酸苯酯 在 sodium 作用下， 以 丙酮 为溶剂， 生成 1-(4-chlorophenyl)-3-(hexanimidoyl)-2-thiourea
  参考文献：
  名称：

  Alkanimidoylthioureas

  摘要：

  这项发明的化合物是具有抗生育活性的新型烷基酰基硫脲。它们是通过适当的烷基酰胺与适当的异硫氰酸酯反应制备的。

  公开号：

  US04039575A1

文献信息

• [EN] HETEROAROMATIC AND HETEROBICYCLIC AROMATIC DERIVATIVES FOR THE TREATMENT OF FERROPTOSIS-RELATED DISORDERS<br/>[FR] DÉRIVÉS AROMATIQUES HÉTÉROBICYCLIQUES ET HÉTÉROAROMATIQUES POUR LE TRAITEMENT DE TROUBLES LIÉS À LA FERROPTOSE
  申请人：COLLABORATIVE MEDICINAL DEV LLC

  公开号：WO2020185738A1

  公开（公告）日：2020-09-17

  The present application discloses heteroaromatic and heterobicyclic aromatic derivative compounds and compositions, and methods for treating ferroptosis-related disorders and diseases in patients using the compounds and compositions as disclosed herein.

  本申请公开了杂芳和杂双环芳香衍生物化合物和组合物，以及利用所公开的化合物和组合物治疗患者的铁死亡相关疾病和疾病的方法。
• Anthelmintic 1-(substituted phenyl)-3-alkanimidoyl ureas
  申请人：Sterling Drug Inc.

  公开号：US03984467A1

  公开（公告）日：1976-10-05

  The compounds of this invention are novel imidoylureas having anthelmintic activity and imidoylthioureas having antifertility activity. They are prepared by the reaction of appropriate amidines with appropriate isocyanates or isothiocyanates.

  本发明的化合物是具有驱虫活性的新型咪唑脲和具有抗生育活性的咪唑硫脲。它们是通过适当的脲类化合物与适当的异氰酸酯或异硫氰酸酯反应制备而成。
• [EN] METHODS OF EXTENDING LIFESPAN BY ADMINISTERING FERROPTOSIS INHIBITORS<br/>[FR] PROCÉDÉS DE PROLONGEMENT DE LA DURÉE DE VIE PAR ADMINISTRATION D'INHIBITEURS DE LA FERROPTOSE
  申请人：COLLABORATIVE MEDICINAL DEV LLC

  公开号：WO2022020150A1

  公开（公告）日：2022-01-27

  Provided herein is a method of extending the lifespan of an organism comprising administering to the organism an effective amount of a ferroptosis inhibitor. Also provided are compositions for extending lifespan comprising ferroptosis inhibitors.

  本文提供了一种延长生物寿命的方法，包括向生物体内施加有效量的铁死亡抑制剂。还提供了包含铁死亡抑制剂的延长寿命的组合物。
• Hemorrhoid treatment pad
  申请人：The Procter and Gamble Company

  公开号：EP2085099A1

  公开（公告）日：2009-08-05

  A hemorrhoid treatment pad, the hemorrhoid treatment pad having a substance on a body facing surface thereof, the substance comprising a skin care composition. The skin care composition can have from about 0.001% to about 0.1% by weight of hexamidine; from about 0.001% to about 10% by weight of zinc oxide; from about 0.01% to about 10% by weight of niacinamide; and a carrier.

  一种痔疮治疗垫，该痔疮治疗垫在其面向身体的表面上有一种物质，该物质包括一种护肤组合物。护肤组合物可以有约 0.001%至约 0.1%（按重量计）的己脒；约 0.001%至约 10%（按重量计）的氧化锌；约 0.01%至约 10%（按重量计）的烟酰胺；以及载体。
• Sanitary napkins with hydrophobic lotions
  申请人：The Procter and Gamble Company

  公开号：EP2103315A2

  公开（公告）日：2009-09-23

  A catamenial device, said device comprising: a topsheet having a body facing surface, wherein said topsheet has a level of hydrophobicity, a lotion composition applied to at least a portion of at least to the body facing surface of said topsheet, said lotion having a level of hydrophobicity equal or greater than that of said topsheet, said lotion composition comprising from about 60% to about 99.9% by weight of the carrier wherein the carrier is selected from the group consisting of petroleum-based hydrocarbons having from about 4 to about 32 carbon atoms, fatty alcohols having from about 12 to about 24 carbon atoms, lower alcohols having from about 1 to about 6 carbon atoms, low molecular weight glycols and polyols, lanolin, and mixtures thereof; a backsheet joined to said topsheet; and an absorbent core disposed between said topsheet and said backsheet.

  一种导尿装置，所述装置包括：具有面向身体表面的表皮，其中所述表皮具有一定的疏水性；涂抹在所述表皮面向身体表面的至少一部分上的乳液组合物，所述乳液的疏水性等于或大于所述表皮的疏水性，所述乳液组合物包括约 60% 至约 99.9%（重量）的载体，其中所述载体选自由以下组成的组：具有约4至约32个碳原子的石油基碳氢化合物、具有约12至约24个碳原子的脂肪醇、具有约1至约6个碳原子的低级醇、低分子量乙二醇和多元醇、羊毛脂，以及它们的混合物；与所述表皮连接的背板；以及设置在所述表皮和所述背板之间的吸收芯。