6-甲基-4,5,6,7-四氢[1,2]噁唑并[5,4-c]吡啶-3(2H)-酮 | 83912-99-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 6-甲基-4,5,6,7-四氢[1,2]噁唑并[5,4-c]吡啶-3(2H)-酮
• 英文名称: 6-Methyl-4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol
• 英文别名: 6-methyl-5,7-dihydro-4H-[1,2]oxazolo[5,4-c]pyridin-3-one
• CAS: 83912-99-6
• 化学式: C₇H₁₀N₂O₂
• 分子量: 154.169
• InChiKey: AVUVYJFAJSMOFQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-甲基-4,5,6,7-四氢[1,2]噁唑并[5,4-c]吡啶-3(2H)-酮 在 吡啶 作用下， 以 丙酮 为溶剂， 反应 2.0h， 生成 6-Methyl-2-(pyrrolidine-1-carbonyl)-4,5,6,7-tetrahydro-isoxazolo[5,4-c]pyridin-3-one; compound with oxalic acid
  参考文献：
  名称：

  Haefliger; Revesz; Maurer, European Journal of Medicinal Chemistry, 1984, vol. 19, # 2, p. 149 - 156

  摘要：

  DOI：

文献信息

• Bicyclic compounds as ATX inhibitors
  申请人：Hoffmann-La Roche Inc.

  公开号：US10882857B2

  公开（公告）日：2021-01-05

  The invention provides novel compounds having the general formula (I) wherein R1, R2, Y, W, A, X, m and n are as defined herein, compositions including the compounds and methods of using the compounds.

  本发明提供了具有通式 (I) 的新型化合物 其中 R1、R2、Y、W、A、X、m 和 n 如本文所定义，本发明还提供了包括这些化合物的组合物和使用这些化合物的方法。
• HAEFLIGER, W.;REVESZ, L.;MAURER, R.;ROMER, D.;BUESCHER, H. -H., EUR. J. MED. CHEM., 1984, 19, N 2, 149-156
  作者：HAEFLIGER, W.、REVESZ, L.、MAURER, R.、ROMER, D.、BUESCHER, H. -H.

  DOI：——

  日期：——
• BICYCLIC COMPOUNDS AS AUTOTAXIN (ATX) AND LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION INHIBITORS
  申请人：F. Hoffmann-La Roche AG

  公开号：EP3122750B1

  公开（公告）日：2019-09-04
• sGC STIMULATORS
  申请人：IRONWOOD PHARMACEUTICALS, INC.

  公开号：US20170291902A1

  公开（公告）日：2017-10-12

  The present patent application discloses at least the compounds according to Formula I′ shown below, or pharmaceutically acceptable salts thereof, wherein ring D, ring A, ring E, ring F, J B , n, J D , o, R C1 , R C2 , W, J E , r, J F , s, Z 1 , Z 2 and Z 3 are as defined herein.
• [EN] SUBSTITUTED AMINOTHIAZOLONE INDAZOLES AS ESTROGEN RELATED RECEPTOR-Aa MODULATORS<br/>[FR] AMINOTHIAZOLONE INDAZOLES SUBSTITUÉS COMME MODULATEURS DES RÉCEPTEURS ALPHA LIÉS AUX OESTROGÈNES
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2011075565A1

  公开（公告）日：2011-06-23

  The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone- related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.