申请人:PHARMACIA & UPJOHN COMPANY
公开号:EP1449835A2
公开(公告)日:2004-08-25
The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula I
and pyrimidine-thioalkyl and alkylethers of Formula IA, namely the compounds of Formula I where
R4 is selected from the group consisting of -H or -NR15R16 where R15 is -H and R16 is -H, C1-C6 alkyl, -NH2 or R15 and R16 taken together with the -N form 1-pyrrolidino, 1-morpholino or 1-piperidino; and
R6 is selected from the group consisting of -H, or halo (preferably -CI); with the overall provisio that R4 and R6 are not both -H;
The compounds of Formula IA are useful in the treatment of individuals who are HIV positive being inhibitors of viral reverse transcriptase.
本发明涉及式 I 的嘧啶硫烷基和烷基醚化合物
和式 IA 的嘧啶硫代烷基和烷基醚,即式 I 的化合物,其中
R4 选自由-H 或-NR15R16 组成的组,其中 R15 为-H,R16 为-H、C1-C6 烷基、-NH2 或 R15 和 R16 与-N 共同形成 1-吡咯烷基、1-吗啉基或 1-哌啶基;以及
R6 选自-H 或卤代物(最好是-CI)组成的组;但 R4 和 R6 不能都是-H;
式 IA 的化合物作为病毒逆转录酶的抑制剂,可用于治疗 HIV 阳性患者。