1-(3-chlorophenyl)-2-p-tolylethane-1,2-dione | 955016-79-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1-(3-chlorophenyl)-2-p-tolylethane-1,2-dione
• 英文别名: 1-(3-Chlorophenyl)-2-(4-methylphenyl)ethane-1,2-dione
• CAS: 955016-79-2
• 化学式: C₁₅H₁₁ClO₂
• 分子量: 258.704
• InChiKey: BLZVDVMUDOKFSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(3-chlorophenyl)-2-p-tolylethane-1,2-dione 在 1,3-bis-n-butylimidazolium bromide 作用下， 以 二甲基亚砜 为溶剂， 生成 5-(3-chlorophenyl)-N-(2-morpholinoethyl)-6-(p-tolyl)-1,2,4-triazin-3-amine
  参考文献：
  名称：

  Design, green synthesis and pharmacological evaluation of novel 5,6-diaryl-1,2,4-triazines bearing 3-morpholinoethylamine moiety as potential antithrombotic agents

  摘要：

  The aim of this research work was to investigate a series of novel 5,6-diaryl-1,2,4-triazines (3a-3q) containing 3-morpholinoethylamine side chain, and to address their antiplatelet activity by in vitro, ex vivo and in vivo methods. All compounds were synthesized by environment benign route and their structures were unambiguously confirmed by spectral data. Compounds (3l) and (3m) were confirmed by their single crystal X-ray structures. Out of all the synthesized compounds, 10 were found to be more potent in vitro than aspirin; six of them were found to be prominent in ex vivo assays and one compound (3d) was found to have the most promising antithrombotic profile in vivo. Moreover, compound (3d) demonstrated less ulcerogenicity in rats as compared to aspirin. The selectivity of the most promising compound (3d) for COX-1 and COX-2 enzymes was determined with the help of molecular docking studies and the results were correlated with the biological activity.

  DOI：

  10.3109/14756366.2015.1060480
• 作为产物：
  描述：

  3-氯苯乙酸 在 三氯化铝 、 selenium(IV) oxide 、 氯化亚砜 作用下， 以 二甲基亚砜 为溶剂， 反应 3.77h， 生成 1-(3-chlorophenyl)-2-p-tolylethane-1,2-dione
  参考文献：
  名称：

  Synthesis of novel substituted diaryl-1,4-diazepines

  摘要：

  DOI：

  10.1007/s10593-006-0178-z

文献信息

• Room-Temperature Ionic Liquid–DMSO Promoted and Improved One-Pot Synthesis of 5,6-Diaryl-1,2,4-triazines
  作者：Riyaj S. Tamboli、Rajani Giridhar、Hemant M. Mande、Shailesh R. Shah、Mange Ram Yadav

  DOI：10.1080/00397911.2014.891040

  日期：2014.8.3

  improved and rapid one-pot synthesis of 5,6-diarylsubstituted-1,2,4-triazines in a mixture of room-temperature ionic liquid 1,3-dibutylimidazolium bromide [Bbim]+Br− and dimethylsulfoxide (DMSO) is described without the need for any added catalyst. Different polar aprotic solvents were screened along with ionic liquids and a synergistic effect with DMSO has been found. The predominance of one regioisomer

  摘要 在室温离子液体溴化 1,3-二丁基咪唑鎓 [Bbim]+Br− 和二甲亚砜 (DMSO) 的混合物中改进和快速一锅法合成 5,6-二芳基取代的-1,2,4-三嗪是无需任何添加的催化剂进行描述。与离子液体一起筛选了不同的极性非质子溶剂，并发现了与 DMSO 的协同效应。还研究了在不同反应温度下一种区域异构体优于另一种区域异构体的情况。通过简单的后处理程序实现了在短时间内获得出色分离产量的一锅法。离子液体被有效回收并重复使用3次而没有失去催化作用。所有化合物均通过红外、核磁共振、质谱和元素分析进行​​表征。图形概要
• Synthesis, antileukemic and antiplatelet activities of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines
  作者：R. Ramajayam、Rajani Giridhar、M.R. Yadav、R. Balaraman、Hakim Djaballah、David Shum、Constantin Radu

  DOI：10.1016/j.ejmech.2007.11.023

  日期：2008.9

  The synthesis, antileukemic and antiplatelet activity evaluation of 2,3-diaryl-6,7-dihydro-5H-1,4-diazepines are described. In general, it was found that compound 17o showed moderate antileukemic activity against MOLT3 human leukemic cancer cell lines. An arachidonic acid induced platelet aggregation effect on washed rat platelets was studied. Compound 17i was found to be the most potent. The antiplatelet

  描述了2,3-二芳基-6,7-二氢-5H-1,4-二氮杂卓的合成，抗白血病和抗血小板活性的评价。通常，发现化合物17o显示出对MOLT3人白血病癌细胞系的中等抗白血病活性。研究了花生四烯酸对洗涤过的大鼠血小板的血小板聚集作用。发现化合物17i是最有效的。抗血小板特性可以通过干扰花生四烯酸途径来介导。
• A Combination of Copper(0) Powder and Selectfluor Enables Generation of Cationic Copper Species for Mild 1,2-Dicarbonylation of Alkynes
  作者：Yunkui Liu、Wenxia Zhang、Jian Zhang、Zhenyuan Xu

  DOI：10.1055/s-0033-1338983

  日期：——

  A combination of copper powder and Selectfluor permits the generation of cationic copper species that efficiently catalyze 1,2-dicarbonylation of alkynes under mild conditions with water and dioxygen as inexpensive and environmentally benign sources of oxygen.